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Protein Overview: AXL2

General Information:
Name(s) found: AXL2 / YIL140W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 823 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [TASLink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    septin ring [TASLink to PubMed article]
    Biological Process: axial cellular bud site selection [TASLink to PubMed article]
    cellular bud site selection [TASLink to PubMed article]
    Molecular Function: molecular_function [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQLQISLLL TATISLLHLV VATPYEAYPI GKQYPPVARV NESFTFQISN DTYKSSVDKT  60
   61 AQITYNCFDL PSWLSFDSSS RTFSGEPSSD LLSDANTTLY FNVILEGTDS ADSTSLNNTY 120
  121 QFVVTNRPSI SLSSDFNLLA LLKNYGYTNG KNALKLDPNE VFNVTFDRSM FTNEESIVSY 180
  181 YGRSQLYNAP LPNWLFFDSG ELKFTGTAPV INSAIAPETS YSFVIIATDI EGFSAVEVEF 240
  241 ELVIGAHQLT TSIQNSLIIN VTDTGNVSYD LPLNYVYLDD DPISSDKLGS INLLDAPDWV 300
  301 ALDNATISGS VPDELLGKNS NPANFSVSIY DTYGDVIYFN FEVVSTTDLF AISSLPNINA 360
  361 TRGEWFSYYF LPSQFTDYVN TNVSLEFTNS SQDHDWVKFQ SSNLTLAGEV PKNFDKLSLG 420
  421 LKANQGSQSQ ELYFNIIGMD SKITHSNHSA NATSTRSSHH STSTSSYTSS TYTAKISSTS 480
  481 AAATSSAPAA LPAANKTSSH NKKAVAIACG VAIPLGVILV ALICFLIFWR RRRENPDDEN 540
  541 LPHAISGPDL NNPANKPNQE NATPLNNPFD DDASSYDDTS IARRLAALNT LKLDNHSATE 600
  601 SDISSVDEKR DSLSGMNTYN DQFQSQSKEE LLAKPPVQPP ESPFFDPQNR SSSVYMDSEP 660
  661 AVNKSWRYTG NLSPVSDIVR DSYGSQKTVD TEKLFDLEAP EKEKRTSRDV TMSSLDPWNS 720
  721 NISPSPVRKS VTPSPYNVTK HRNRHLQNIQ DSQSGKNGIT PTTMSTSSSD DFVPVKDGEN 780
  781 FCWVHSMEPD RRPSKKRLVD FSNKSNVNVG QVKDIHGRIP EML

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) AMN1 AXL2 IMH1 PEX19 PFK27 RAX2 RGT2 RIC1 RIX7 RPA190 SST2 TRX1 TRX2 YLR035C-A
    View Details Qiu et al. (2008) AXL2 CDC11 CDC12 CDC3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RIX7 No Comments Hazbun TR, et al. (2003)
    View Run ZDS1 Sample zds1 from august 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRP42 AXL2 1 Unpublished Fields Lab Data
    View Screen UBC6 AXL2 1 Unpublished Fields Lab Data
    View Screen CDC23 AXL2 1 Unpublished Fields Lab Data
    View Screen TOP3 AXL2 1 Unpublished Fields Lab Data
    View Screen UBC7 AXL2 1 Unpublished Fields Lab Data
    View Screen SPO1 AXL2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data AXL2 Sundin BA, et al. (2004)
    View Data AXL2 Sundin BA, et al. (2004)
    View Data AXL2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] PSI-BLAST 2.154902 Invasin
    2 View Details [149..242] PSI-BLAST 30.69897 Intimin
    3 View Details [243..326] PSI-BLAST 30.69897 Intimin
    4 View Details [327..442] PSI-BLAST 30.69897 Intimin
    5 View Details [443..823] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.95444025761215 bayes_pls_golite062009
  • protein binding
    		•  1.27159851877663 bayes_pls_golite062009
  • receptor activity
    		•  1.06696607894653 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.537960312630809 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.296113784946944 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.185231656572514 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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