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Protein Overview: ROM1

General Information:
Name(s) found: ROM1 / YGR070W [SGD]
Description(s) found:
Found 19 descriptions.
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  • GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1155 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: small GTPase mediated signal transduction [IPILink to PubMed article]
    cellular cell wall organization [IPILink to PubMed article]
    actin filament organization [TASLink to PubMed article]
    budding cell bud growth [IPILink to PubMed article]
    Molecular Function: Rho guanyl-nucleotide exchange factor activity [IMPLink to PubMed article]
    signal transducer activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSNELDLRN KYFYEIFGKK RKSDTSTPTQ LFSGSKVQTN INEISITNDE DEDSTEDENK  60
   61 ASLKDYTLGH DTGARYRIAP DCSSHQLKAS PVLHISTNLN SSPQSFTGDQ ISPTNKKISI 120
  121 NDSTRQDKGN SCTTTSSPSQ KRSNVLLPHV RKHSSPSLLS FSKNSGSHMG DPNQLSTPPT 180
  181 PKSAGHTMEL HSSFNGKHSS SSTSSLFALE SLKTQNRRSS NSSNHSSQYR RHTNQHQRHH 240
  241 SRSKSSPVSL TEISMIKGTP LVYPALLSLI AIKFKQTIKL STHKKMGLLY RDSFTGKQAI 300
  301 DTLCLIIGSL DRNLGMLIGK SLEAQKLFHD VLYDHGVRDS VLEIYELSSE SIFMAHQSQS 360
  361 STSIANTFSS SSSSVNSLRT KTEIYGVFVP LTHCYSSTCS LEKLCYSISC PNRLQQQANL 420
  421 HLKLGGGLKR NISLALDKED DERISWTNSV PKSVWESLSK QQIKRQEAIY ELFTTEKKFV 480
  481 KSLEIIRDTF MKKLLETNII PSDVRINFVK HVFAHINEIY SVNREFLKAL AQRQSLSPIC 540
  541 PGIADIFLQY LPFFDPFLSY IASRPYAKYL IETQRSVNPN FARFDDEVSN SSLRHGIDSF 600
  601 LSQGVSRPGR YSLLVREIIH FSDPVTDKDD LQMLMKVQDL LKDLMKRIDR ASGAAQDRYD 660
  661 VKVLKQKILF KNEYVNLGLN NEKRKIKHEG LLSRKDVNKT DASFSGDIQF YLLDNMLLFL 720
  721 KSKAVNKWHQ HTVFQRPIPL PLLFICPAED MPPIKRYVTE NPNCSAGVLL PQYQTSNPKN 780
  781 AIVFAYYGTK QQYQVTLYAP QPAGLQTLIE KVKQEQKRLL DETKHITFKQ MVGQFFHSYI 840
  841 NTNRVNDVLI CHAGKILLVA TNMGLFVLNY ATSINQKPVH LLHKISISQI SVLEEYKVMI 900
  901 LLIDKKLYGC PLDVIDDAEN ADFLFRKNSK VLFKYVAMFK DGFCNGKRII MIAHHFLHAA 960
  961 QLLIVNPLIF DFNSGNFKKN LKAGLVDFSV DSEPLSFSFL ENKICIGCKK NIKILNVPEV1020
 1021 CDKNGFKMRE LLNLHDNKVL ANMYKETFKV VSMFPIKNST FACFPELCFF LNKQGKREET1080
 1081 KGCFHWEGEP EQFACSYPYI VAINSNFIEI RHIENGELVR CVLGNKIRML KSYAKKILYC1140
 1141 YEDPQGFEII ELLNF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ROM1 APL2 2 Unpublished Fields Lab Data
    View Screen ROM1 RNP1 2 Unpublished Fields Lab Data
    View Screen ROM1 HSM3 2 Unpublished Fields Lab Data
    View Screen ROM1 UFO1 2 Unpublished Fields Lab Data
    View Screen ROM1 PET494 2 Unpublished Fields Lab Data
    View Screen ROM1 ARN1 2 Unpublished Fields Lab Data
    View Screen ROM1 POP2 2 Unpublished Fields Lab Data
    View Screen ROM1 FUN19 1 Unpublished Fields Lab Data
    View Screen ROM1 YJR003C 1 Unpublished Fields Lab Data
    View Screen ROM1 KAR9 1 Unpublished Fields Lab Data
    View Screen ROM1 AVT5 1 Unpublished Fields Lab Data
    View Screen ROM1 CPR7 1 Unpublished Fields Lab Data
    View Screen MET18 ROM1 1 Unpublished Fields Lab Data
    View Screen ROM1 YBL108W 1 Unpublished Fields Lab Data
    View Screen ROM1 SHE2 1 Unpublished Fields Lab Data
    View Screen ROM1 YBR012C 1 Unpublished Fields Lab Data
    View Screen ROM1 HSP26 1 Unpublished Fields Lab Data
    View Screen ROM1 YLR140W 1 Unpublished Fields Lab Data
    View Screen ROM1 YDR132C 1 Unpublished Fields Lab Data
    View Screen ROM1 SML1 1 Unpublished Fields Lab Data
    View Screen ROM1 NKP1 1 Unpublished Fields Lab Data
    View Screen ROM1 PPN1 1 Unpublished Fields Lab Data
    View Screen ROM1 RRP5 1 Unpublished Fields Lab Data
    View Screen ROM1 GCN4 1 Unpublished Fields Lab Data
    View Screen ROM1 LIP1 1 Unpublished Fields Lab Data
    View Screen ROM1 CHO1 1 Unpublished Fields Lab Data
    View Screen ROM1 YMR306C-A 1 Unpublished Fields Lab Data
    View Screen FUN19 ROM1 1 Unpublished Fields Lab Data
    View Screen ROM1 SPR6 1 Unpublished Fields Lab Data
    View Screen ROM1 COX5A 1 Unpublished Fields Lab Data
    View Screen ROM1 ROX3 1 Unpublished Fields Lab Data
    View Screen ROM1 HAC1 1 Unpublished Fields Lab Data
    View Screen ROM1 NAR1 1 Unpublished Fields Lab Data
    View Screen ROM1 RAD18 1 Unpublished Fields Lab Data
    View Screen ROM1 YFL065C 1 Unpublished Fields Lab Data
    View Screen ROM1 MIC14 1 Unpublished Fields Lab Data
    View Screen ROM1 PEX18 1 Unpublished Fields Lab Data
    View Screen ROM1 YPS6 1 Unpublished Fields Lab Data
    View Screen ROM1 YPL141C 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..268] ORFEUS 12.1 RBP1
    2 View Details [269..400] Pfam 16.721246 Domain found in Dishevelled, Egl-10, and Pleckstrin No confident structure predictions are available.
    3 View Details [401..455] deduced N/A No confident structure predictions are available.
    4 View Details [456..654] PSI-BLAST 160.927757 GEF of intersectin
    5 View Details [655..839] PSI-BLAST 160.927757 GEF of intersectin
    6 View Details [840..1155] Pfam 89.60206 CNH domain No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.73671056234733 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.39919853201545 bayes_pls_golite062009
  • DNA binding
    		•  2.16143325457938 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.09113880936999 bayes_pls_golite062009
  • transcription factor activity
    		•  1.54168457775536 bayes_pls_golite062009
  • protein binding
    		•  0.726445167461826 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.287205124844904 bayes_pls_golite062009
  • transcription activator activity
    		•  0.125095059983242 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0268276479020184 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  1.74397599086046 bayes_pls_golite062009
  • protein binding
    		•  1.14503622489775 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.628909211572624 bayes_pls_golite062009
  • actin binding
    		•  0.451110433048089 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.149708921127291 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle