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Protein Overview: NAR1

General Information:
Name(s) found: NAR1 / YNL240C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 491 amino acids

    Gene Ontology:
    Cellular Component: membrane [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: iron-sulfur cluster assembly [IMPLink to PubMed article]
    Molecular Function: ferredoxin hydrogenase activity [ISS]
    metal ion binding [IEA]
    4 iron, 4 sulfur cluster binding [IEA]
    iron-sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALLSESDL NDFISPALAC VKPTQVSGGK KDNVNMNGEY EVSTEPDQLE KVSITLSDCL  60
   61 ACSGCITSSE EILLSSQSHS VFLKNWGKLS QQQDKFLVVS VSPQCRLSLA QYYGLTLEAA 120
  121 DLCLMNFFQK HFQCKYMVGT EMGRIISISK TVEKIIAHKK QKENTGADRK PLLSAVCPGF 180
  181 LIYTEKTKPQ LVPMLLNVKS PQQITGSLIR ATFESLAIAR ESFYHLSLMP CFDKKLEASR 240
  241 PESLDDGIDC VITPREIVTM LQELNLDFKS FLTEDTSLYG RLSPPGWDPR VHWASNLGGT 300
  301 CGGYAYQYVT AVQRLHPGSQ MIVLEGRNSD IVEYRLLHDD RIIAAASELS GFRNIQNLVR 360
  361 KLTSGSGSER KRNITALRKR RTGPKANSRE MAAATAATAD PYHSDYIEVN ACPGACMNGG 420
  421 GLLNGEQNSL KRKQLVQTLN KRHGEELAMV DPLTLGPKLE EAAARPLSLE YVFAPVKQAV 480
  481 EKDLVSVGST W

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIA1 NAR1 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..491] PSI-BLAST 334.0103 Fe-only hydrogenase, catalytic domain; Fe-only hydrogenase, N-terminal domain; Fe-only hydrogenase, second domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.47874003627413 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  1.31458462821219 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.18054918348653 bayes_pls_golite062009
  • metal cluster binding
    		•  1.18054918348653 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  1.10428419414285 bayes_pls_golite062009
  • lamin binding
    		•  0.863386378061341 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.778342926116907 bayes_pls_golite062009
  • catalytic activity
    		•  0.488483980994331 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.312816353615077 bayes_pls_golite062009
  • ferredoxin hydrogenase activity
    		•  0.278768281741128 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
    		•  0.278768281741128 bayes_pls_golite062009
  • protein binding
    		•  0.221871950373022 bayes_pls_golite062009
  • electron carrier activity
    		•  0.0554226204149908 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle