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Protein Overview: VPS45

General Information:
Name(s) found: VPS45 / YGL095C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 577 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Golgi membrane [IDALink to PubMed article]
    extrinsic to membrane [IDALink to PubMed article]
    Biological Process: protein complex assembly [IMPLink to PubMed article]
    vacuole organization [IMPLink to PubMed article]
    Golgi to vacuole transport [IMPLink to PubMed article]
    Molecular Function: unfolded protein binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLFDVADFY INKIVTSQSK LSVANVNEHQ RIKVLLLDKN TTPTISLCAT QSELLKHEIY  60
   61 LVERIENEQR EVSRHLRCLV YVKPTEETLQ HLLRELRNPR YGEYQIFFSN IVSKSQLERL 120
  121 AESDDLEAVT KVEEIFQDFF ILNQDLFSFD LQPREFLSNK LVWSEGGLTK CTNSLVSVLL 180
  181 SLKIKPDIRY EGASKICERL AKEVSYEIGK NERTFFDFPV MDSTPVLLIL DRNTDPITPL 240
  241 LQPWTYQSMI NEYIGIKRNI VDLSKVPRID KDLEKVTLSS KQDAFFRDTM YLNFGELGDK 300
  301 VKQYVTTYKD KTQTNSQINS IEDIKNFIEK YPEFRKLSGN VAKHMAIVGE LDRQLKIKNI 360
  361 WEISEIEQNL SAHDANEEDF SDLIKLLQNE AVDKYYKLKL ACIYSLNNQT SSDKIRQLVE 420
  421 ILSQQLPPED VNFFHKFKSL FSRQDKMTQS NHDKDDILTE LARRFNSRMN SKSNTAENVY 480
  481 MQHIPEISSL LTDLSKNALF RDRFKEIDTQ GHRVIGNQQS KDIPQDVILF VIGGVTYEEA 540
  541 RLVHDFNGTM NNRMRVVLGG TSILSTKEYM DSIRSAK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RPN1 RPN5 RPN6 RPT5 TFC3 TLG2 UBP6 VPS45
    View Details Krogan NJ, et al. (2006) ADE2 BSC2 CWH41 DBF4 DIG1 ECM29 HAL5 LAA1 MRC1 OPI9 PEX32 PRP5 PTH2 RGA2 RMA1 RPN3 SIR1 STE12 THR1 TLG2 VPS45 YDL199C YEL057C YPL035C
    View Details Gavin AC, et al. (2002) SEC17 SLY1 TLG1 TLG2 VPS45 VTI1 YKT6
    View Details Qiu et al. (2008) GGA1 PEP3 VPS45 VPS52 VTI1 YOS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen FUN19 VPS45 2 Unpublished Fields Lab Data
    View Screen URN1 VPS45 2 Unpublished Fields Lab Data
    View Screen HBT1 VPS45 2 Unpublished Fields Lab Data
    View Screen RGD2 VPS45 2 Unpublished Fields Lab Data
    View Screen TAM41 VPS45 2 Unpublished Fields Lab Data
    View Screen IML1 VPS45 2 Unpublished Fields Lab Data
    View Screen MPE1 VPS45 2 Unpublished Fields Lab Data
    View Screen BUR2 VPS45 2 Unpublished Fields Lab Data
    View Screen SPO21 VPS45 2 Unpublished Fields Lab Data
    View Screen BUD7 VPS45 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS45 and CHC1 Huh WK, et al. (2003)
    View Data VPS45 Huh WK, et al. (2003)
    View Data VPS45 and COP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] PSI-BLAST 423.0103 Neuronal Sec1, NSec1
    2 View Details [137..244]
    [484..577]    		 PSI-BLAST 423.0103 Neuronal Sec1, NSec1
    3 View Details [245..356] PSI-BLAST 423.0103 Neuronal Sec1, NSec1
    4 View Details [357..483] PSI-BLAST 423.0103 Neuronal Sec1, NSec1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNARE binding
    		•  4.56428593085019 bayes_pls_golite062009
  • syntaxin binding
    		•  3.46044132736061 bayes_pls_golite062009
  • binding
    		•  2.7837022903231 bayes_pls_golite062009
  • protein binding
    		•  2.77285532000616 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.269372794919901 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle