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View Structure Prediction Details

Protein: VPS45
Organism: Saccharomyces cerevisiae
Length: 577 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS45.

Description E-value Query
Range		 Subject
Range
VPS45 - Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the functi...
VPS45_YEAST - Vacuolar protein sorting-associated protein 45 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
 0.0 [1..577] [1..577]
STXB2_CANLF - Syntaxin-binding protein 2 OS=Canis lupus familiaris GN=STXBP2 PE=2 SV=1
 0.0 [7..575] [2..582]
STXBP2 - syntaxin binding protein 2
gi|208967548 - gi|208967548|dbj|BAG73788.1| syntaxin binding protein 2 [synthetic construct]
 0.0 [7..575] [2..582]
STXB2_MOUSE - Syntaxin-binding protein 2 OS=Mus musculus GN=Stxbp2 PE=1 SV=1
 0.0 [7..575] [2..582]
STXB2_RAT - Syntaxin-binding protein 2 OS=Rattus norvegicus GN=Stxbp2 PE=2 SV=1
 0.0 [7..575] [2..583]
unc-18 - Acetylcholine regulator unc-18 status:Confirmed UniProt:P34815 protein_id:AAA93389.2
 0.0 [3..574] [82..665]

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Predicted Domain #1
Region A:
Residues: [1-136] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLFDVADFY INKIVTSQSK LSVANVNEHQ RIKVLLLDKN TTPTISLCAT QSELLKHEIY  60
   61 LVERIENEQR EVSRHLRCLV YVKPTEETLQ HLLRELRNPR YGEYQIFFSN IVSKSQLERL 120
  121 AESDDLEAVT KVEEIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 423.0103
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SNARE binding 4.56428593085019 bayes_pls_golite062009
syntaxin binding 3.46044132736061 bayes_pls_golite062009
binding 2.7837022903231 bayes_pls_golite062009
protein binding 2.77285532000616 bayes_pls_golite062009
syntaxin-1 binding 0.269372794919901 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [137-244] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDFFILNQDL FSFDLQPREF LSNKLVWSEG GLTKCTNSLV SVLLSLKIKP DIRYEGASKI  60
   61 CERLAKEVSY EIGKNERTFF DFPVMDSTPV LLILDRNTDP ITPLLQPW

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [484-577] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPEISSLLTD LSKNALFRDR FKEIDTQGHR VIGNQQSKDI PQDVILFVIG GVTYEEARLV  60
   61 HDFNGTMNNR MRVVLGGTSI LSTKEYMDSI RSAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 423.0103
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [245-356] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TYQSMINEYI GIKRNIVDLS KVPRIDKDLE KVTLSSKQDA FFRDTMYLNF GELGDKVKQY  60
   61 VTTYKDKTQT NSQINSIEDI KNFIEKYPEF RKLSGNVAKH MAIVGELDRQ LK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 423.0103
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [357-483] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKNIWEISEI EQNLSAHDAN EEDFSDLIKL LQNEAVDKYY KLKLACIYSL NNQTSSDKIR  60
   61 QLVEILSQQL PPEDVNFFHK FKSLFSRQDK MTQSNHDKDD ILTELARRFN SRMNSKSNTA 120
  121 ENVYMQH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 423.0103
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle