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Protein Overview: unc-18

General Information:
Name(s) found: unc-18 / CE24927 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00006757 locus:unc-18 Putative acetylcholine regulator unc-18 status:Confirmed UniProt:P34815 protein_id:CCD67914.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 591 amino acids

    Gene Ontology:
    Cellular Component: axon [IDALink to PubMed article]
    Biological Process: synaptic vesicle docking during exocytosis [IMPLink to PubMed article]
    vesicle-mediated transport [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    positive regulation of neurotransmitter secretion [IMPLink to PubMed article]
    vesicle docking during exocytosis [IEALink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKQIVGHK LLNDVIRPLK KGDGRSAWNV LIVDTLAMRM LSSCCKMHNI MEEGITIVED  60
   61 LNKRREPLPT LEAIYLIAPT AESIDKLIQD YCARNLYKCA HVFFTEACSD QLFSTLSKSA 120
  121 AARFIKTLKE INIAFTPYES QVFNLDSPDT FFLYYNAQKQ GGLTSNLERI AEQIATVCAT 180
  181 LGEYPSLRYR ADFERNVELG HLVEQKLDAY KADDPSMGEG ADKARSQLII IDRGYDAITP 240
  241 LLHELTLQAM CYDLLGIEND VYKYETGGSD ENLEKEVLLD ENDDLWVEMR HKHIAVVSQE 300
  301 VTKNLKKFSE SKGNKGTMDS KSIKDLSMLI KRMPQHKKEL NKFSTHISLA EECMKQYQQG 360
  361 VDKLCKVEQD LSTGIDAEGE RVRDAMKLMV PLLIDPAVRC EDRLRLILLY ILSKNGITDE 420
  421 NLNKLLQHAN ISMADKETIT NAAYLGLNIV TDTGRKKTWT PTKKERPHEQ VYQSSRWVPV 480
  481 IKDIIEDAID ERLDTKHFPF LAGRQVNQGY RAPASARYGQ WHKERGQQSN YRSGPRLIIY 540
  541 IIGGVTFSEM RACYEVTAAR KPWEVVIGSD RIITPDKFLT NLRDLNKPRD I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..591] PSI-BLAST 160.0 Neuronal Sec1, NSec1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNARE binding
    		•  4.56428593085019 bayes_pls_golite062009
  • syntaxin binding
    		•  3.46044132736061 bayes_pls_golite062009
  • binding
    		•  2.7837022903231 bayes_pls_golite062009
  • protein binding
    		•  2.77285532000616 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.269372794919901 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle