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Protein Overview: GDI1

General Information:
Name(s) found: GDI1 / YER136W [SGD]
Description(s) found:
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  • gi|729566|sp|P39958.1|GDI1_YEAST RecName: Full=Rab GDP-dissociation inhibitor; Short=Rab GDI; AltName: Full=Secretory pathway GDP dissociation inhibitor [NCBI NR]
  • gi|6320983|ref|NP_011062.1| GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins; Gdi1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S44446 GDP dissociation inhibitor GDI1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|603375|gb|AAC03234.1| Gdi1p: secretory pathway GDP dissociation inhibitor [Saccharomyces cerevisiae] [NCBI NR]
  • gi|546371|gb|AAB30540.1| Gdi1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|187609400|pdb|3CPJ|G Chain G, Crystal Structure Of Ypt31 In Complex With Yeast Rab-Gdi [NCBI NR]
  • gi|187609399|pdb|3CPI|H Chain H, Crystal Structure Of Yeast Rab-Gdi [NCBI NR]
  • gi|187609398|pdb|3CPI|G Chain G, Crystal Structure Of Yeast Rab-Gdi [NCBI NR]
  • gi|187609397|pdb|3CPH|H Chain H, Crystal Structure Of Sec4 In Complex With Rab-Gdi [NCBI NR]
  • gi|187609395|pdb|3CPH|G Chain G, Crystal Structure Of Sec4 In Complex With Rab-Gdi [NCBI NR]
  • Rab GDP-dissociation inhibitor OS=Saccharomyces cerevisiae GN=GDI1 PE=1 SV=1 [Swiss-Prot]
  • GDI1 GDP dissociation inhibitor [mips]
  • GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins [SGD]
  • GDI1, Chr V from 439612-440967 [yeast_orfs2]
  • Chr V from 439612-440967 [yeastorf3.fasta]
  • (P39958) Secretory pathway GDP dissociation inhibitor [4932.FASTACCERV.txt]
  • GDI1 SGDID:S0000938, Chr V from 439612-440967, Verified ORF [yeastflysequest.fasta]
  • Gdi1p [Saccharomyces cerevisiae]gi|603375|gb|AAC03234.1| Gdi1p: secretory pathway GDP dissociation inhibitor [Saccharomyces cerevisiae]gi|729566|sp|P39958|GDI1_YEAST Secretory pathway GDP dissociation inhibitorgi|630001|pir||S44446 GDP dissociation in [nrdb_11152004_Chlamydomonas]
  • GDI1 SGDID:S000000938, Chr V from 439612-440967, Verified ORF, "GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Gdi1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Rab GDP-dissociation inhibitor (Rab GDI) (Secretory pathway GDP dissociation inhibitor) [nr-271106-contam.fasta]
  • GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins; Gdi1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Gdi1p: secretory pathway GDP dissociation inhibitor [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Rab GDP-dissociation inhibitor OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GDI1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GDI1 SGDID:S000000938, Chr V from 439616-440971, Genome Release 64-1-1, Verified ORF, "GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins" [yeast-030211-contam.fasta]
  • GDI1 SGDID:S000000938, Chr V from 439616-440971, Genome Release 64-2-1, Verified ORF, "GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins" [20141208_orf_trans.fasta]
  • TR8190|c0_g1_i1|g.5823 ORF TR8190|c0_g1_i1|g.5823 TR8190|c0_g1_i1|m.5823 type:complete len:452 (+) TR8190|c0_g1_i1:173-1528(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YER136W SGDID:S000000938, Chr V from 439616-440971, Genome Release 64-1-1, Verified ORF, "GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_7623|g.4827 ORF ID=asmbl_7623|g.4827 ID=asmbl_7623|m.4827 type:complete len:452 (+) ID=asmbl_7623:138-1493(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 451 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    soluble fraction [IDALink to PubMed article]
    Biological Process: vesicle-mediated transport [IMPLink to PubMed article]
    Molecular Function: Rab GDP-dissociation inhibitor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQETIDTDY DVIVLGTGIT ECILSGLLSV DGKKVLHIDK QDHYGGEAAS VTLSQLYEKF  60
   61 KQNPISKEER ESKFGKDRDW NVDLIPKFLM ANGELTNILI HTDVTRYVDF KQVSGSYVFK 120
  121 QGKIYKVPAN EIEAISSPLM GIFEKRRMKK FLEWISSYKE DDLSTHQGLD LDKNTMDEVY 180
  181 YKFGLGNSTK EFIGHAMALW TNDDYLQQPA RPSFERILLY CQSVARYGKS PYLYPMYGLG 240
  241 ELPQGFARLS AIYGGTYMLD TPIDEVLYKK DTGKFEGVKT KLGTFKAPLV IADPTYFPEK 300
  301 CKSTGQRVIR AICILNHPVP NTSNADSLQI IIPQSQLGRK SDIYVAIVSD AHNVCSKGHY 360
  361 LAIISTIIET DKPHIELEPA FKLLGPIEEK FMGIAELFEP REDGSKDNIY LSRSYDASSH 420
  421 FESMTDDVKD IYFRVTGHPL VLKQRQEQEK Q

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDI1 MRS6 VPS21 YPT1 YPT31 YPT52 YPT6
    View Details Krogan NJ, et al. (2006) GDI1 IDP3 MRS6 VPS21 YPT6
    View Details Gavin AC, et al. (2006) GDI1 YPT31 YPT52
    View Details Gavin AC, et al. (2002) GDI1 YPT1 YPT31 YPT52
    View Details Ho Y, et al. (2002) ACH1 ACO1 ADH4 ADH6 BIO3 CDC33 DSS4 ECM10 ERG20 FPR1 GDI1 HOM3 HSH49 MAM33 MDH1 MRS6 PTC7 QCR2 RAD26 RAD3 RGP1 RHR2 RIC1 RNA1 SEC4 SEC53 STE11 TEF4 TFP1 TIF1, TIF2 TMA29 TPS1 VPS21 YPT1 YPT10 YPT31 YPT32 YPT52 YPT53 YPT6 YPT7 YSP2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 sample: hx2 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GDI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..451] PSI-BLAST 2430.0 Guanine nucleotide dissosiation inhibitor, GDI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small GTPase regulator activity
    		•  1.82777033221452 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.69589677829425 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.67690582043816 bayes_pls_golite062009
  • binding
    		•  1.28745887296004 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.00883251592654 bayes_pls_golite062009
  • amine oxidase activity
    		•  0.93095855430028 bayes_pls_golite062009
  • GDP-dissociation inhibitor activity
    		•  0.387378304822822 bayes_pls_golite062009
  • protein binding
    		•  0.347133050347128 bayes_pls_golite062009
  • transporter activity
    		•  0.0442116448779152 bayes_pls_golite062009
  • antioxidant activity
    		•  0.0209903577090486 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.00424758775661527 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle