YRC Public Data Repository - Protein Structure Prediction

Protein:	GDI1
Organism:	Saccharomyces cerevisiae
Length:	451 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GDI1.

Description	E-value	Query Range	Subject Range
gi\|238566800, gi... - gi\|240849331\|ref\|NP_001155343.1\| GDP dissociation inhibitor 1 [Ovis aries], gi\|238566800\|gb\|ACR46634... GDIA_BOVIN - Rab GDP dissociation inhibitor alpha OS=Bos taurus GN=GDI1 PE=1 SV=1	0.0	[6..449]	[1..438]
gi\|217418277 - gi\|217418277\|gb\|ACK44281.1\| GDP dissociation inhibitor 1 (predicted) [Oryctolagus cuniculus] GDIA_RAT - Rab GDP dissociation inhibitor alpha OS=Rattus norvegicus GN=Gdi1 PE=1 SV=1	0.0	[6..449]	[1..438]
GDIA_MOUSE - Rab GDP dissociation inhibitor alpha OS=Mus musculus GN=Gdi1 PE=1 SV=3	0.0	[6..449]	[1..438]
GDI1 - GDP dissociation inhibitor 1 gi\|146741460 - gi\|146741460\|dbj\|BAF62386.1\| GDP dissociation inhibitor 1 [Pan troglodytes verus] GDIA_PANTR - Rab GDP dissociation inhibitor alpha OS=Pan troglodytes GN=GDI1 PE=2 SV=1 gi\|117646846, gi... - gi\|60821495\|gb\|AAX36577.1\| GDP dissociation inhibitor 1 [synthetic construct], gi\|208966356\|dbj\|BAG7...	0.0	[6..449]	[1..438]
gi\|151944855 - gi\|151944855\|gb\|EDN63114.1\| GDP dissociation inhibitor [Saccharomyces cerevisiae YJM789] GDI1 - GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissoc... GDI1_YEAST - Rab GDP-dissociation inhibitor OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GDI1 PE=1... gi\|190405696 - gi\|190405696\|gb\|EDV08963.1\| GDP dissociation inhibitor [Saccharomyces cerevisiae RM11-1a] gi\|207345841 - gi\|207345841\|gb\|EDZ72532.1\| YER136Wp-like protein [Saccharomyces cerevisiae AWRI1631]	0.0	[1..451]	[1..451]
GDIA_CANLF - Rab GDP dissociation inhibitor alpha OS=Canis lupus familiaris GN=GDI1 PE=2 SV=1	0.0	[6..449]	[1..438]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[6..449]	[1..438]

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Predicted Domain #1

Region A:
Residues: [1-451]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQETIDTDY DVIVLGTGIT ECILSGLLSV DGKKVLHIDK QDHYGGEAAS VTLSQLYEKF  60
   61 KQNPISKEER ESKFGKDRDW NVDLIPKFLM ANGELTNILI HTDVTRYVDF KQVSGSYVFK 120
  121 QGKIYKVPAN EIEAISSPLM GIFEKRRMKK FLEWISSYKE DDLSTHQGLD LDKNTMDEVY 180
  181 YKFGLGNSTK EFIGHAMALW TNDDYLQQPA RPSFERILLY CQSVARYGKS PYLYPMYGLG 240
  241 ELPQGFARLS AIYGGTYMLD TPIDEVLYKK DTGKFEGVKT KLGTFKAPLV IADPTYFPEK 300
  301 CKSTGQRVIR AICILNHPVP NTSNADSLQI IIPQSQLGRK SDIYVAIVSD AHNVCSKGHY 360
  361 LAIISTIIET DKPHIELEPA FKLLGPIEEK FMGIAELFEP REDGSKDNIY LSRSYDASSH 420
  421 FESMTDDVKD IYFRVTGHPL VLKQRQEQEK Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2430.0
Match:	1gnd__
Description:	Guanine nucleotide dissosiation inhibitor, GDI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
small GTPase regulator activity	1.82777033221452	bayes_pls_golite062009
GTPase regulator activity	1.69589677829425	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.67690582043816	bayes_pls_golite062009
binding	1.28745887296004	bayes_pls_golite062009
enzyme regulator activity	1.00883251592654	bayes_pls_golite062009
amine oxidase activity	0.93095855430028	bayes_pls_golite062009
GDP-dissociation inhibitor activity	0.387378304822822	bayes_pls_golite062009
protein binding	0.347133050347128	bayes_pls_golite062009
transporter activity	0.0442116448779152	bayes_pls_golite062009
antioxidant activity	0.0209903577090486	bayes_pls_golite062009
transcription regulator activity	0.00424758775661527	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: