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Protein Overview: TPA1

General Information:
Name(s) found: TPA1 / YER049W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 644 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    translational readthrough [IMPLink to PubMed article]
    mRNA catabolic process [IMPLink to PubMed article]
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRKTAEVKG EKERNSKQIS LEEDKIKGMF NPKIWDKTFQ DGLKKEIEDS QPYNWGTIHE  60
   61 LVNDDLLRAV RKEIETEIHF TKKETDIYRV NQSGDLANLS GLDWDDLSRL PNLFKLRQIL 120
  121 YSKQYRDFFG YVTKAGKLSG SKTDMSINTY TKGCHLLTHD DVIGSRRISF ILYLPDPDRK 180
  181 WKSHYGGGLR LFPSILPNVP HSDPSAKLVP QFNQIAFFKV LPGFSFHDVE EVKVDKHRLS 240
  241 IQGWYHIPQV GEEGYIPGEE EAWVRNNTST LAQIESNVLE DFEFPKDERN ILSFHEVKHF 300
  301 EKMLKGDAGA KTDNTPKESM TSVISDSVKL SEAEFTYLSQ YISPEHLSSK GIEKLQKQFV 360
  361 ENSSLQIESF LNDDKSELLK KVIKQKELEQ ECPYHSKDVK APWKTAIPPH KARYLYIDGK 420
  421 EYRNFQTEAD ILEALNNNDL PNFQFTKDAI KIISDASGNS RENNFDAELA LIDLAVFHKS 480
  481 TIFKKYLALL TSLCPVSEQI LIRRFRPGMD FTLATKCRFN ELLKSNPDII DAVLEGTLCL 540
  541 TPSAGWESGE LGGYELYMMD DDEDNKQYLK EDVEDASVYR ADDSGDSVLI NDPPAWNTFN 600
  601 LVLRDESVLE FVKYVSWSAK SSRWDVKMKW DVKSCDEDGQ EDEA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) RLM1 TPA1 VAM6 YOR051C
    View Details Ho Y, et al. (2002) ARG4 AYR1 COR1 CPR6 ERG27 GPT2 LIA1 MAE1 OM45 PCT1 PDA1 PET10 PET9 PIL1 PRE10 PRO3 RET2 RNR2 RTN2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 TIF34 TIF35 TPA1 YNL181W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RPN11 TPA1 2 Unpublished Fields Lab Data
    View Screen GSP1 TPA1 2 Unpublished Fields Lab Data
    View Screen RNR3 TPA1 1 Unpublished Fields Lab Data
    View Screen MET18 TPA1 1 Unpublished Fields Lab Data
    View Screen RCY1 TPA1 1 Unpublished Fields Lab Data
    View Screen YJR056C TPA1 1 Unpublished Fields Lab Data
    View Screen CDC16 TPA1 1 Unpublished Fields Lab Data
    View Screen RPP0 TPA1 1 Unpublished Fields Lab Data
    View Screen TPT1 TPA1 1 Unpublished Fields Lab Data
    View Screen RPB2 TPA1 1 Unpublished Fields Lab Data
    View Screen RPB2 TPA1 1 Unpublished Fields Lab Data
    View Screen APC5 TPA1 1 Unpublished Fields Lab Data
    View Screen PRP6 TPA1 1 Unpublished Fields Lab Data
    View Screen SWI5 TPA1 1 Unpublished Fields Lab Data
    View Screen BRR2 TPA1 1 Unpublished Fields Lab Data
    View Screen DMC1 TPA1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TPA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] deduced N/A No confident structure predictions are available.
    2 View Details [137..306] Pfam 10.455932 2OG-Fe(II) oxygenase superfamily No confident structure predictions are available.
    3 View Details [307..644] deduced N/A No confident structure predictions are available.
    4 View Details [408..644] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle