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Protein Overview: VPS74

General Information:
Name(s) found: VPS74 / YDR372C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 345 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLQRRRVN RADSGDTSSI HSSANNTKGD KIANIAVDGD DDNGTNKKIA YDPEESKLRD  60
   61 NINIPTLTLM EEVLLMGLRD REGYLSFWND SISYALRGCI IIELALRGKI RILDDSARKR 120
  121 FDLSERLIEV IDSSKTGEVL LDETLQLMKN DEPLSISNWI DLLSGETWNL LKINYQLKQV 180
  181 RERLAKGLVD KGVLRTEMKN FFLFDMATHP IADASCKEAI KRRVLSVLVS RNMELSYNEY 240
  241 FPETTSFKII RTLALICGSY GANVLENVLT TLEYEKRDKA ISRAEEIMAQ FSQYPFDLEK 300
  301 ETELGVSVNL NKEVKEEIEN NPGHDLQLEV IAGVFEVFSR MDMLL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) VPS74 YLR149C
    View Details Ho Y, et al. (2002) AHA1 ARP2 ATP3 CPR6 IDH1 NMD5 PET10 PHO84 PPH21 PPH22 PRB1 REP1 RPN8 SDH2 SPS1 VMA8 VPS74 YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS74 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] deduced N/A No confident structure predictions are available.
    2 View Details [65..345] MSA 3.012952 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle