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Protein Overview: UFD2

General Information:
Name(s) found: UFD2 / YDL190C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 961 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: ubiquitin cycle [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    response to stress [IMPLink to PubMed article]
    ubiquitin-dependent protein catabolic process [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAIEDILQI TTDPSDTRGY SLLKSEEVPQ GSTLGVDFID TLLLYQLTEN EKLDKPFEYL  60
   61 NDCFRRNQQQ KRITKNKPNA ESLHSTFQEI DRLVIGYGVV ASQIENFCMN GAFINYITGI 120
  121 VSNVNSYTDF LSQIIQRAIL EGTALDLLNA VFPTLLEYCN KHVSHFDLNE SVIYNNVLTI 180
  181 FELFVTFKPI AEIFTKIDGF FADYSCKPQD FERKTILGPI LSLSPIEAAV AIRNYGDNLL 240
  241 RSKQQTAMIH ESLQAEHKVV IDRLFFIVDK LVRGSLNSRT DMISYFAHIA NKNHLRRADH 300
  301 PPFKELSSNG FMSNITLLLV RFSQPFLDIS YKKIDKIDAN YFNNPSLFID LSGETRLNSD 360
  361 FKEADAFYDK NRKTADSKPN FISDCFFLTL TYLHYGLGGT LSFEEKMGSE IKALKEEIEK 420
  421 VKKIAANHDV FARFITAQLS KMEKALKTTE SLRFALQGFF AHRSLQLEVF DFICGASTFL 480
  481 IRVVDPEHEF PFKQIKLPLI PDQIGVENVD NADFLRAHAP VPFKYYPEFV VEGPVNYSLY 540
  541 ISKYQTSPIF RNPRLGSFVE FTTMVLRCPE LVSNPHLKGK LVQLLSVGAM PLTDNSPGFM 600
  601 MDIFEHDELV NKNLLYALLD FYVIVEKTGS SSQFYDKFNS RYSISIILEE LYYKIPSYKN 660
  661 QLIWQSQNNA DFFVRFDARM LNDLTFLLDE GLSNLAEVHN IQNELDNRAR GAPPTREEED 720
  721 KELQTRLASA SRQAKSSCGL ADKSMKLFEI YSKDIPAAFV TPEIVYRLAS MLNYNLESLV 780
  781 GPKCGELKVK DPQSYSFNPK DLLKALTTVY INLSEQSEFI SAVAKDERSF NRNLFVRAVD 840
  841 ILGRKTGLAS PEFIEKLLNF ANKAEEQRKA DEEEDLEYGD VPDEFLDPLM YTIMKDPVIL 900
  901 PASKMNIDRS TIKAHLLSDS TDPFNRMPLK LEDVTPNEEL RQKILCFKKQ KKEEAKHKAS 960
  961 E

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC48 UFD2
    View Details Krogan NJ, et al. (2006) BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C
    View Details Ho Y, et al. (2002) DSK2 ENV7 HMF1 NPL4 RAD23 SHP1 TSL1 UBI4 UFD2 YDR049W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC48 UFD2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data UFD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] MSA 1.016972 View MSA. No confident structure predictions are available.
    2 View Details [197..669] deduced N/A No confident structure predictions are available.
    3 View Details [670..886] PSI-BLAST 2.221849 Heavy meromyosin subfragment
    4 View Details [887..961] PSI-BLAST 3.39794 bard1 RING domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle