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Protein Overview: PGI1

General Information:
Name(s) found: PGI1 / YBR196C [SGD]
Description(s) found:
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  • pir||NUBY glucose-6-phosphate isomerase (EC 5.3.1.9) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6319673|ref|NP_009755.1| Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation; Pgi1p [Sa [NCBI NR]
  • gi|536565|emb|CAA85158.1| PGI1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|4135|emb|CAA32158.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|311672|emb|CAA79683.1| glycolytic enzyme phosphoglucoisomerase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|172225|gb|AAA34894.1| phosophoglucoisomerase (EC 5.3.1.9) [NCBI NR]
  • gi|172142|gb|AAA34862.1| phosphoglucose isomerase (EC 5.3.1.9) [Saccharomyces cerevisiae] [NCBI NR]
  • gi|120745|sp|P12709.3|G6PI_YEAST RecName: Full=Glucose-6-phosphate isomerase; Short=GPI; AltName: Full=Phosphoglucose isomerase; Short=PGI; AltName: Full=Phosphohexose isomerase; Short=PHI [NCBI NR]
  • Glucose-6-phosphate isomerase OS=Saccharomyces cerevisiae GN=PGI1 PE=1 SV=3 [Swiss-Prot]
  • PGI1 Glucose-6-phosphate isomerase [mips]
  • Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation [SGD]
  • PGI1, Chr II from 612194-613858, reverse complement [yeast_orfs2]
  • Chr II from 612194-613858, reverse complement [yeastorf3.fasta]
  • Chr II from 612193-613857, reverse complement [yeastorf4.fasta]
  • Chr II from 613855-612191, reverse complement [yeastorf5.fasta]
  • PGI1 SGDID:S0000400, Chr II from 613857-612193, reverse complement, Verified ORF [yeastflysequest.fasta]
  • PGI1 SGDID:S0000400, Chr II from 613895-612231, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation [Saccharomyces cerevisiae]gi|311672|e [nrdb_11152004_Chlamydomonas]
  • PGI1 SGDID:S000000400, Chr II from 613895-612231, reverse complement, Verified ORF, "Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and complet [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • phosphoglucose isomerase (EC 5.3.1.9) [nr-271106-contam.fasta]
  • Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) [nr-271106-contam.fasta]
  • phosophoglucoisomerase (EC 5.3.1.9) [nr-271106-contam.fasta]
  • glycolytic enzyme phosphoglucoisomerase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation; Pgi1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PGI1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PGI1 SGDID:S000000400, Chr II from 613895-612231, reverse complement, Verified ORF, "Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Glucose-6-phosphate isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGI1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PGI1 SGDID:S000000400, Chr II from 613900-612236, Genome Release 64-1-1, reverse complement, Verified ORF, "Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation" [yeast-030211-contam.fasta]
  • PGI1 SGDID:S000000400, Chr II from 613900-612236, Genome Release 64-2-1, reverse complement, Verified ORF, "Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation" [20141208_orf_trans.fasta]
  • TR7187|c0_g1_i1|g.5138 ORF TR7187|c0_g1_i1|g.5138 TR7187|c0_g1_i1|m.5138 type:complete len:555 (+) TR7187|c0_g1_i1:4707-6371(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YBR196C SGDID:S000000400, Chr II from 613900-612236, Genome Release 64-1-1, reverse complement, Verified ORF, "Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_5110|g.3321 ORF asmbl_5110|g.3321 asmbl_5110|m.3321 type:complete len:555 (+) asmbl_5110:44-1708(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_4778|g.3121 ORF ID=asmbl_4778|g.3121 ID=asmbl_4778|m.3121 type:complete len:555 (+) ID=asmbl_4778:44-1708(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 554 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    cytosol [TAS]
    Biological Process: gluconeogenesis [IMPLink to PubMed article]
    pentose-phosphate shunt [IMPLink to PubMed article]
    glycolysis [IMPLink to PubMed article]
    Molecular Function: glucose-6-phosphate isomerase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNSFTNFK LATELPAWSK LQKIYESQGK TLSVKQEFQK DAKRFEKLNK TFTNYDGSKI  60
   61 LFDYSKNLVN DEIIAALIEL AKEANVTGLR DAMFKGEHIN STEDRAVYHV ALRNRANKPM 120
  121 YVDGVNVAPE VDSVLKHMKE FSEQVRSGEW KGYTGKKITD VVNIGIGGSD LGPVMVTEAL 180
  181 KHYAGVLDVH FVSNIDGTHI AETLKVVDPE TTLFLIASKT FTTAETITNA NTAKNWFLSK 240
  241 TGNDPSHIAK HFAALSTNET EVAKFGIDTK NMFGFESWVG GRYSVWSAIG LSVALYIGYD 300
  301 NFEAFLKGAE AVDNHFTQTP LEDNIPLLGG LLSVWYNNFF GAQTHLVAPF DQYLHRFPAY 360
  361 LQQLSMESNG KSVTRGNVFT DYSTGSILFG EPATNAQHSF FQLVHQGTKL IPSDFILAAQ 420
  421 SHNPIENKLH QKMLASNFFA QAEALMVGKD EEQVKAEGAT GGLVPHKVFS GNRPTTSILA 480
  481 QKITPATLGA LIAYYEHVTF TEGAIWNINS FDQWGVELGK VLAKVIGKEL DNSSTISTHD 540
  541 ASTNGLINQF KEWM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADH1 HSC82 PGI1
    View Details Krogan NJ, et al. (2006) AIM22 DPH1 DPH2 EFT2, EFT1 HGH1 MNN1 PGI1 RRG10 TRX1 YMR315W
    View Details Gavin AC, et al. (2006) GAA1 PGI1 SEC1
    View Details Gavin AC, et al. (2002) ADH1 GIN4 HMO1 KCC4 PBP2 PDC1 PGI1 RAD1 RAD10 SEC1 YEF3 YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run DSN1 No Comments Hazbun TR, et al. (2003)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PGI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108]
    [309..516]    		 PSI-BLAST 11000.0 Phosphoglucose isomerase, PGI
    2 View Details [109..308]
    [517..554]    		 PSI-BLAST 11000.0 Phosphoglucose isomerase, PGI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glucose-6-phosphate isomerase activity
    		•  3.62042557708076 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  2.12646274924126 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting aldoses and ketoses
    		•  1.62962150339138 bayes_pls_golite062009
  • catalytic activity
    		•  1.5278037255884 bayes_pls_golite062009
  • sugar binding
    		•  1.40175307923331 bayes_pls_golite062009
  • glutamine-fructose-6-phosphate transaminase (isomerizing) activity
    		•  1.11549102314657 bayes_pls_golite062009
  • binding
    		•  1.0425673151455 bayes_pls_golite062009
  • D-sedoheptulose 7-phosphate isomerase activity
    		•  0.969046173332955 bayes_pls_golite062009
  • isomerase activity
    		•  0.875614547872629 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.5730945843207 bayes_pls_golite062009
  • protein binding
    		•  0.152745336606766 bayes_pls_golite062009
  • transferase activity
    		•  0.0523744832826621 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  0.0239994594084577 bayes_pls_golite062009
  • transaminase activity
    		•  0.00531525548288503 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle