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A metabolic process by which a pool of NADPH generated by the reduction of NADP+. The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process by which glucose is oxidized, coupled to NADPH synthesis. The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2). The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: pentose-phosphate shunt
Acc: GO:0006098
Aspect: Biological Process
Desc: The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.
Synonyms:
  • pentose phosphate shunt
  • pentose-phosphate pathway
  • pentose phosphate pathway
  • hexose monophosphate pathway
Proteins in PDR annotated with:
   This term: 128 [Search]
   Term or descendants: 176 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006098 - pentose-phosphate shunt (interactive image map)

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