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Protein Overview: gi|2288927

General Information:
Name(s) found: gi|2288927 [NCBI NR]
Description(s) found:
Found 2 descriptions.
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  • gi|2288927|emb|CAA04188.1| Janus protein tyrosine kinase 2 [Rattus norvegicus] [NCBI NR]
    • Organism: Rattus norvegicus
    Length: 691 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDA]
    nucleus [UNKNOWN][IDA][ISS]
    caveola [UNKNOWN][IEA]
    cytoskeleton [IEA]
    cytoplasm [UNKNOWN][IDA]
    membrane [IEA]
    membrane raft [UNKNOWN]
    cytosol [IDA]
    endomembrane system [IEA]
    nuclear matrix [IDA]
    Biological Process: chromatin modification [IEA]
    peptidyl-tyrosine phosphorylation [UNKNOWN]
    activation of JAK2 kinase activity [UNKNOWN][ISS]
    positive regulation of phosphoinositide 3-kinase cascade [IEA]
    negative regulation of cell-cell adhesion [IMP]
    protein amino acid autophosphorylation [UNKNOWN][IMP][ISS]
    positive regulation of DNA binding [IMP]
    positive regulation of transcription factor activity [IMP]
    JAK-STAT cascade [UNKNOWN][IDA]
    hormone-mediated signaling pathway [IDA]
    activation of MAPKK activity [IMP]
    negative regulation of DNA binding [UNKNOWN][IEA]
    apoptosis [UNKNOWN]
    mineralocorticoid receptor signaling pathway [IMP]
    tyrosine phosphorylation of Stat3 protein [IMP]
    tyrosine phosphorylation of STAT protein [UNKNOWN]
    JAK-STAT cascade involved in growth hormone signaling pathway [UNKNOWN][ISS]
    positive regulation of growth hormone receptor signaling pathway [IEA]
    G-protein coupled receptor protein signaling pathway [IMP]
    tyrosine phosphorylation of Stat1 protein [IMP]
    STAT protein nuclear translocation [UNKNOWN][IEA]
    positive regulation of inflammatory response [IMP]
    induction of apoptosis by oxidative stress [IMP]
    platelet-derived growth factor receptor signaling pathway [IMP]
    erythrocyte differentiation [ISS]
    positive regulation of phosphoprotein phosphatase activity [IMP]
    myeloid cell differentiation [UNKNOWN]
    axon regeneration [IMP]
    positive regulation of cell migration [IMP]
    neuroprotection [IMP]
    positive regulation of protein import into nucleus, translocation [IMP]
    positive regulation of nitric oxide biosynthetic process [IMP]
    positive regulation of tyrosine phosphorylation of Stat3 protein [IEA]
    negative regulation of cell proliferation [UNKNOWN][IEA]
    positive regulation of cell proliferation [IMP]
    response to antibiotic [UNKNOWN][IEA]
    negative regulation of heart contraction [IMP]
    response to oxidative stress [IMP]
    cytokine-mediated signaling pathway [ISS]
    positive regulation of insulin secretion [IMP]
    positive regulation of peptidyl-tyrosine phosphorylation [IEA]
    response to hydroperoxide [IMP]
    signal transduction [ISS]
    intracellular protein kinase cascade [UNKNOWN]
    positive regulation of cell differentiation [IMP]
    enzyme linked receptor protein signaling pathway [UNKNOWN][IEA]
    positive regulation of tyrosine phosphorylation of Stat5 protein [IEA]
    elevation of cytosolic calcium ion concentration [IMP]
    positive regulation of apoptosis [IMP]
    cell differentiation [UNKNOWN]
    positive regulation of cell activation [IMP]
    positive regulation of interleukin-1 beta production [IMP]
    Molecular Function: phosphoinositide 3-kinase binding [IPI]
    acetylcholine receptor binding [IPI]
    interleukin-12 receptor binding [UNKNOWN][IEA]
    growth hormone receptor binding [IPI]
    SH2 domain binding [UNKNOWN][IEA]
    receptor binding [UNKNOWN]
    nucleotide binding [IEA]
    ATP binding [IEA]
    protein tyrosine kinase activity [UNKNOWN]
    protein binding [UNKNOWN]
    non-membrane spanning protein tyrosine kinase activity [IEA]
    histone binding [UNKNOWN][ISS]
    insulin receptor substrate binding [IPI]
    Janus kinase activity [UNKNOWN][IMP][ISS]
    peptide hormone receptor binding [IPI]
    transferase activity [IEA]
    histone kinase activity (H3-Y41 specific) [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HNILYRIRFY FPHWYCSGSN RTYRYGVSRG AEAPLLDDFV MSYLFAQWRH DFVHGWIKVP  60
   61 VTHETQEECL GMAVLDMMRI AKEKDQTPLA VYNSISYKTF LPKCVRAKDY HILTRKRIRY 120
  121 RFRRFIQQFS QCKATARDLK LKYLINLETL QSAFYTEQFE VKESARGPSG EEIFATIIIT 180
  181 GNGGIQWSRG KHKESETLTE QDLQLYCDFP DIIDVSIKQA NQECSTESRV VTVHKQDGKV 240
  241 LEIELSSLKE ALSFVSLIDG YYRLTADAHH YLCKEVAPPA VLENIHSNCH GPISMVFAIS 300
  301 KLKRAGNQTG LYVLRCSPKD FNKYFLTFAV ERENVIEYKH CLITKNENGE YNLSGTKRNF 360
  361 SSLKDLLNCY QMETVRSDSI IFQLTKCCPP KPKDKSNLLV FRTNGVSDVQ LSPTLQRHNN 420
  421 VNQMVFHKIR NEDLVFNESL GQGTFTKIFK GVRREVGDYG QLHETEVLLK VLDKAHRNYS 480
  481 ESFFEAASMM SQLSHKHLVL NYGVCVCGEE NILVQEFVKF GSLDTYLKKN KNSINILWKL 540
  541 GVAKQLAWAM HFLEEKSLIH GNVCAKNILL IREEDRKTGN PPFIKLSEPG ISITVLPKDI 600
  601 LQERIPWVPP ECIENPKNLT LATDKWSFGT TLWEICSGGD KPLSALDSQR KLQFYEDKHQ 660
  661 LPAPKWTELA NLINTCMDYE PDFRPAFRAV I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle