| Protein: | mek-2 |
| Organism: | Caenorhabditis elegans |
| Length: | 387 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mek-2.
| Description | E-value | Query Range |
Subject Range |
|
|
287.0 | [0..1] | [387..1] |
|
Region A: Residues: [1-68] |
1 11 21 31 41 51
| | | | | |
1 MSSGKRRNPL GLSLPPTVNE QSESGEATAE EATATVPLEE QLKKLGLTEP QTQRLSEFLQ 60
61 VKEGIKEL
|
| Detection Method: |  |
| Confidence: | 23.30103 |
| Match: | 2pziA |
| Description: | No description for 2pziA was found. |
|
Region A: Residues: [69-387] |
1 11 21 31 41 51
| | | | | |
1 SEDMLQTEGE LGHGNGGVVN KCVHRKTGVI MARKLVHLEI KPSVRQQIVK ELAVLHKCNS 60
61 PFIVGFYGAF VDNNDISICM EYMDGLSLDI VLKKVGRLPE KFVGRISVAV VRGLTYLKDE 120
121 IKILHRDVKP SNMLVNSNGE IKLCDFGVSG MLIDSMANSF VGTRSYMAPE RLTGSHYTIS 180
181 SDIWSFGLSL VELLIGRYPV PAPSQAEYAT MFNVAENEIE LADSLEEPNY HPPSNPASMA 240
241 IFEMLDYIVN GPPPTLPKRF FTDEVIGFVS KCLRKLPSER ATLKSLTADV FFTQYADHDD 300
301 QGEFAVFVKG TINLPKLNP
|
| Detection Method: | |
| Confidence: | 65.0 |
| Match: | 1s9jA |
| Description: | X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 4.62392503670521 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.79505438761262 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.59526003830791 | bayes_pls_golite062009 |
| signal transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| molecular transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| receptor activity | 2.39311927684508 | bayes_pls_golite062009 |
| transferase activity | 2.34875558765742 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.25301480460598 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.188721764136 | bayes_pls_golite062009 |
| tubulin binding | 2.18641675163967 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.12618184009486 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| MAP kinase 2 activity | 1.93464174962664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| microtubule binding | 1.88110801192607 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| PTB domain binding | 1.69692410125184 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.65350201428136 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| growth factor binding | 1.53863828216563 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| JUN kinase kinase kinase activity | 1.45392497707807 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.28428643482914 | bayes_pls_golite062009 |
| kinase binding | 1.26086833316556 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.22172815474021 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| actin-dependent ATPase activity | 1.21636393741109 | bayes_pls_golite062009 |
| structural constituent of muscle | 1.19908793854422 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 1.16995153203536 | bayes_pls_golite062009 |
| transcription repressor activity | 1.14496167267281 | bayes_pls_golite062009 |
| histone kinase activity (H3-S10 specific) | 1.14432210832726 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 1.10045286406485 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 1.10045286406485 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 1.08910497299188 | bayes_pls_golite062009 |
| protein kinase binding | 1.06030596516506 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| receptor binding | 0.990272341309676 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| cation channel activity | 0.752655339263581 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.75189004129952 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 0.728507215600658 | bayes_pls_golite062009 |
| growth factor activity | 0.707777793848936 | bayes_pls_golite062009 |
| telethonin binding | 0.564849360244591 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 0.537170519944039 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| actin binding | 0.456340967230669 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.451090007290896 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 0.442502307901785 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| polysaccharide binding | 0.344522125452779 | bayes_pls_golite062009 |
| heparin binding | 0.334438853447262 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.318153468064373 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.26579358730346 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| SH2 domain binding | 0.226760162354251 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.150740450460731 | bayes_pls_golite062009 |
| activin binding | 0.13882559598219 | bayes_pls_golite062009 |
| insulin-like growth factor binding | 0.0364367558658403 | bayes_pls_golite062009 |
| MAP kinase kinase kinase kinase activity | 0.01826424351081 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
