YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: FBpp0292491, FBp...
Organism: Drosophila melanogaster
Length: 606 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0292491, FBp....

Description E-value Query
Range		 Subject
Range
gi|74003739 - gi|74003739|ref|XP_535855.2| PREDICTED: similar to Protein kinase C, iota type (nPKC-iota) (Atypical...
 530.0 [0..2] [606..99]

Back

Predicted Domain #1
Region A:
Residues: [1-114] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKMPSQILN DGSSVSLNSA SMNMANTPNS ITVKTAYNGQ IIITTINKNI SYEELCYEIR  60
   61 NICRFPLDQP FTIKWVDEEN DPCTISTKME LDEAIRLYEM NFDSQLVIHV FPNV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.30103
Match: 1vd2A
Description: Solution Structure of the PB1 domain of PKCiota
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [115-519] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQAPGLSCDG EDRSIYRRGA RRWRKLYRVN GHIFQAKRFN RRAFCAYCQD RIWGLGRQGF  60
   61 KCIQCKLLVH KKCHKLVQKH CTDQPEPLVK ERAEESSDPI PVPLPPLPYE AMSGGAEACE 120
  121 THDHAHIVAP PPPEDPLEPG TQRQYSLNDF ELIRVIGRGS YAKVLMVELR RTRRIYAMKV 180
  181 IKKALVTDDE DIDWVQTEKH VFETASNHPF LVGLHSCFQT PSRLFFVIEF VRGGDLMYHM 240
  241 QRQRRLPEEH ARFYAAEISL ALNFLHEKGI IYRDLKLDNV LLDHEGHIKL TDYGMCKEGI 300
  301 RPGDTTSTFC GTPNYIAPEI LRGEDYGFSV DWWALGVLLY EMLAGRSPFD LAGASENPDQ 360
  361 NTEDYLFQVI LEKTIRIPRS LSVRAASVLK GFLNKNPADR LGCHR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 2ptkA
Description: CHICKEN SRC TYROSINE KINASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
phosphoinositide 3-kinase binding 3.43994026029707 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
transmembrane receptor activity 3.14527324856472 bayes_pls_golite062009
SH2 domain binding 3.03401803018883 bayes_pls_golite062009
receptor activity 2.92302133496371 bayes_pls_golite062009
actin binding 2.91722352767433 bayes_pls_golite062009
signal transducer activity 2.82134497010588 bayes_pls_golite062009
molecular transducer activity 2.82134497010588 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
vinculin binding 2.81520439694489 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 2.11611043663195 bayes_pls_golite062009
transforming growth factor beta receptor activity 2.11611043663195 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
insulin binding 2.0719180171079 bayes_pls_golite062009
tau-protein kinase activity 2.00481226596005 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 1.92111648893005 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
actin-dependent ATPase activity 1.88428037554272 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
actin filament binding 1.75933904320288 bayes_pls_golite062009
MAP kinase kinase kinase kinase activity 1.70795227184717 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
insulin receptor activity 1.32196787649813 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
epidermal growth factor receptor binding 1.24312972088703 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
activin binding 1.17357465780187 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.11664317075762 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
PTB domain binding 1.09159018564123 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
telethonin binding 1.04264263421201 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 1.03150090191995 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.950774777422509 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.828948654336299 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of muscle 0.767275562047313 bayes_pls_golite062009
activin receptor activity 0.759766561351959 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
ErbB-2 class receptor binding 0.657156113273289 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transcription repressor activity 0.568332175782799 bayes_pls_golite062009
peptide binding 0.532669337315477 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
3-phosphoinositide-dependent protein kinase binding 0.372842462336059 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
myosin binding 0.259936573810332 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
alpha-actinin binding 0.181804774839734 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
activin receptor activity, type I 0.0667996033448706 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [520-606] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESAFMDIVSH PFFKNMDWEL LERKQVTPPF KPRLDSDRDL ANFPPEFTGE AVQLTPDDDH  60
   61 VIDNIDQSEF EGFEYVNPLL MSLEDCV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.09691
Match: 1zrzA
Description: Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle