YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|149052165, gi...
Organism:	Rattus norvegicus
Length:	281 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|149052165, gi....

Description	E-value	Query Range	Subject Range
gi\|68357540, gi\|... - gi\|94536665\|ref\|NP_001035438.1\| RAB40c, member RAS oncogene family [Danio rerio], gi\|92096570\|gb\|AAI...	257.0	[0..1]	[281..1]
gi\|17390073 - gi\|17390073\|gb\|AAH18039.1\| RAB40B, member RAS oncogene family [Homo sapiens]	255.0	[0..1]	[281..1]
gi\|51593537, gi\|... - gi\|51593537\|gb\|AAH78543.1\| MGC85390 protein [Xenopus laevis], gi\|147905476\|ref\|NP_001087313.1\| MGC85...	255.0	[0..1]	[281..1]
gi\|50757677 - gi\|50757677\|ref\|XP_415603.1\| PREDICTED: similar to MGC85390 protein [Gallus gallus]	254.0	[0..1]	[281..1]
gi\|34875697, gi\|... - gi\|34875697\|ref\|XP_221213.2\| PREDICTED: similar to Rab40b, member RAS oncogene family [Rattus norveg...	253.0	[0..1]	[281..2]
RB40B_MOUSE - Ras-related protein Rab-40B OS=Mus musculus GN=Rab40b PE=2 SV=1	253.0	[0..1]	[281..1]
gi\|118403982, gi... - gi\|118403982\|ref\|NP_001072188.1\| RAB40B, member RAS oncogene family [Xenopus (Silurana) tropicalis],...	251.0	[0..1]	[281..1]

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Predicted Domain #1

Region A:
Residues: [1-201]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG  60
   61 RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP 120
  121 RILVGNRLHL AFKRQVPTEQ ARAYAEKNCM TFFEVSPLCN FNVIESFTEL SRIVLMRHGM 180
  181 EKIWRPNRVF SLQDLCCRAI V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.0
Match:	1ukvY
Description:	Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTPase activity	4.52394549632777	bayes_pls_golite062009
microtubule motor activity	4.51968578934603	bayes_pls_golite062009
motor activity	4.04927796049806	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
tubulin binding	2.67743463093593	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.61311581579476	bayes_pls_golite062009
microtubule binding	2.59155206524122	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
microfilament motor activity	2.51786963027655	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.50934147358924	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
cytoskeletal protein binding	2.4101693596493	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
G-protein coupled receptor activity	2.3505608190884	bayes_pls_golite062009
actin binding	2.2973522188675	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
DNA helicase activity	2.2817164193758	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
guanyl nucleotide binding	1.89320355239381	bayes_pls_golite062009
guanyl ribonucleotide binding	1.88721318481223	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.88455339138556	bayes_pls_golite062009
GTP binding	1.87900088157196	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.56325751172863	bayes_pls_golite062009
ribonucleotide binding	1.53142082854758	bayes_pls_golite062009
purine nucleotide binding	1.52938239070386	bayes_pls_golite062009
purine ribonucleotide binding	1.52887308780164	bayes_pls_golite062009
nucleotide binding	1.52746968836881	bayes_pls_golite062009
signal recognition particle binding	1.46975774710831	bayes_pls_golite062009
plus-end-directed microtubule motor activity	1.38366133153678	bayes_pls_golite062009
apolipoprotein receptor activity	1.31055516357904	bayes_pls_golite062009
syntaxin-13 binding	1.31055516357904	bayes_pls_golite062009
apolipoprotein A-I binding	1.31055516357904	bayes_pls_golite062009
apolipoprotein A-I receptor activity	1.31055516357904	bayes_pls_golite062009
protein-DNA loading ATPase activity	1.29640539057136	bayes_pls_golite062009
actin filament binding	1.28204719195916	bayes_pls_golite062009
transmembrane receptor activity	1.26314334516725	bayes_pls_golite062009
ATP binding	1.23942044024113	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
adenyl ribonucleotide binding	1.21044170258803	bayes_pls_golite062009
receptor activity	1.20313362488821	bayes_pls_golite062009
adenyl nucleotide binding	1.19481945569892	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
signal transducer activity	1.13474466330485	bayes_pls_golite062009
molecular transducer activity	1.13474466330485	bayes_pls_golite062009
DNA clamp loader activity	1.12431517057397	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.11794390756322	bayes_pls_golite062009
kinase activity	1.11120928120082	bayes_pls_golite062009
nucleotide kinase activity	1.10251779925246	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ion transmembrane transporter activity	0.977237423302079	bayes_pls_golite062009
actin-dependent ATPase activity	0.92105578610354	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.908046791062776	bayes_pls_golite062009
transcription activator activity	0.889929694023098	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
protein methyltransferase activity	0.876296121718575	bayes_pls_golite062009
structure-specific DNA binding	0.782430219754236	bayes_pls_golite062009
microtubule plus-end binding	0.673980113049624	bayes_pls_golite062009
steroid hormone receptor binding	0.647625526012423	bayes_pls_golite062009
histone methyltransferase activity	0.63002958837536	bayes_pls_golite062009
cell surface binding	0.618263399939881	bayes_pls_golite062009
double-stranded DNA binding	0.6071273686445	bayes_pls_golite062009
telomeric DNA binding	0.60010060632866	bayes_pls_golite062009
sterol transporter activity	0.57614280790431	bayes_pls_golite062009
cation transmembrane transporter activity	0.557919489256916	bayes_pls_golite062009
sequence-specific DNA binding	0.543891899378373	bayes_pls_golite062009
ribonucleoprotein binding	0.53788302029845	bayes_pls_golite062009
kinetochore binding	0.505370954958131	bayes_pls_golite062009
protein transmembrane transporter activity	0.46552249844591	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.442220326523999	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.421921195209539	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	0.40217318916177	bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific)	0.394426489405446	bayes_pls_golite062009
drug transmembrane transporter activity	0.38711726712063	bayes_pls_golite062009
DNA strand annealing activity	0.370730612975529	bayes_pls_golite062009
hormone receptor binding	0.351501100511918	bayes_pls_golite062009
protein kinase activity	0.351308564667977	bayes_pls_golite062009
peptide binding	0.304703625340488	bayes_pls_golite062009
nuclear hormone receptor binding	0.246160342138071	bayes_pls_golite062009
structural constituent of ribosome	0.208665086324262	bayes_pls_golite062009
RNA helicase activity	0.18426050934025	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
RNA-dependent ATPase activity	0.14606996093053	bayes_pls_golite062009
amine-transporting ATPase activity	0.135455889967401	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.13050483816765	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	0.12351419478929	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.123304946374679	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.0775601177068852	bayes_pls_golite062009
structural constituent of muscle	0.0436357112276422	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0111338193708552	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [202-281]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCTPVHLIDK LPLPVTIKSH LKSFSMANGM NAVMMHGRSY SLASGAGGSG SKGNSLKRSK  60
   61 SIRPPQSPPQ NCSRSNCKIS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: