YRC Public Data Repository - Protein Structure Prediction

Protein:	CKA1
Organism:	Saccharomyces cerevisiae
Length:	372 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CKA1.

Description	E-value	Query Range	Subject Range
CDC21_ORYSA, CC2... - Cell division control protein 2 homolog 1 (EC 2.7.11.22) - Oryza sativa (Rice), (P29618) Cell divisi... CDKA1_ORYSJ - Cyclin-dependent kinase A-1 OS=Oryza sativa subsp. japonica GN=CDKA-1 PE=1 SV=1	0.0	[38..366]	[2..290]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[38..366]	[2..290]
gi\|4096103 - gi\|4096103\|gb\|AAD10483.1\| p34cdc2 [Triticum aestivum]	0.0	[38..365]	[2..289]
CDC2_MAIZE - Cell division control protein 2 homolog OS=Zea mays GN=CDC2 PE=2 SV=1	0.0	[38..366]	[2..290]
CDC2_OXYRB - Cell division control protein 2 homolog OS=Oxybasis rubra GN=CDC2 PE=2 SV=1	0.0	[38..366]	[2..290]
gi\|849068 - gi\|849068\|dbj\|BAA09369.1\| cdc2 homolog [Nicotiana tabacum]	0.0	[38..366]	[2..290]
gi\|8671339 - gi\|8671339\|emb\|CAA56815.2\| cdc2Pnc [Pinus contorta]	0.0	[38..366]	[2..290]

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Predicted Domain #1

Region A:
Residues: [1-13]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKCRVWSEAR VYT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [222-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVNMEYNVRV ASRFFKGPEL LVDYRMYDYS LDLWSFGTML ASMIFKREPF FHGTSNTDQL  60
   61 VKIVKVLGTS DFEKYLLKYE ITLPREFYDM DQYIRKPWHR FINDGNKHLS GNDEIIDLID 120
  121 NLLRYDHQER LTAKEAMGHP WFAPIREQIE K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1107.0
Match:	1jwhA_
Description:	Protein kinase CK2, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cyclin-dependent protein kinase activity	4.62392503670521	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
fibroblast growth factor receptor activity	3.64398689811167	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.54265774272269	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
structural molecule activity	2.32133082120229	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
ion transmembrane transporter activity	2.25301480460598	bayes_pls_golite062009
cation transmembrane transporter activity	2.188721764136	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.16831387024372	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.12618184009486	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
fibroblast growth factor binding	1.86067939172285	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
telethonin binding	1.75733591474207	bayes_pls_golite062009
fibroblast growth factor 1 binding	1.66976264488423	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.65350201428136	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
JUN kinase kinase kinase activity	1.41172362253967	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
cytoskeletal protein binding	1.22172815474021	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.02011129825141	bayes_pls_golite062009
transcription activator activity	0.997272622653026	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
alpha-actinin binding	0.877087652539674	bayes_pls_golite062009
growth factor binding	0.86076618871384	bayes_pls_golite062009
acetylcholine receptor activator activity	0.85335678502604	bayes_pls_golite062009
cation channel activity	0.752655339263581	bayes_pls_golite062009
insulin receptor substrate binding	0.57867852584301	bayes_pls_golite062009
tubulin binding	0.525721160726465	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.47339115370427	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
actin binding	0.456340967230669	bayes_pls_golite062009
substrate-specific transporter activity	0.451090007290896	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
structure-specific DNA binding	0.318153468064373	bayes_pls_golite062009
kinase binding	0.26752427107238	bayes_pls_golite062009
substrate-specific channel activity	0.26579358730346	bayes_pls_golite062009
RNA binding	0.245748631571068	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.20643152368029	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.20643152368029	bayes_pls_golite062009
microtubule binding	0.191960933574742	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.149958560815481	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.149958560815481	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.14842991990838	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.114318824149111	bayes_pls_golite062009
MAP kinase activity	0.08504542461349	bayes_pls_golite062009
protein kinase binding	0.00674998152095019	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [14-31]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NINKQRTEEY WDYENTVI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [75-136]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKKKIKREIK ILTDLSNEKV PPTTLPFQKD QYYTNQKEDV LKFIRPYIFD QPHNGHANII  60
   61 HL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [155-221]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDNVDFRILY PKLTDLEIRF YMFELLKALD YCHSMGIMHR DVKPHNVMID HKNKKLRLID  60
   61 WGLAEFY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1107.0
Match:	1jwhA_
Description:	Protein kinase CK2, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [32-74]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWSTNTKDYE IENKVGRGKY SEVFQGVKLD SKVKIVIKML KPV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [137-154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDIIKDPISK TPALVFEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1107.0
Match:	1jwhA_
Description:	Protein kinase CK2, alpha subunit
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: