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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Erb1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 19 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • EBP2
  • nucleolus
  • nuclear division
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • EXG1
  • fungal-type cell wall
  • cellular glucan metabolic process
  • cellular cell wall organization
  • glucan 1,3-beta-glucosidase activity
  • FPR4
  • nucleus
  • chromatin
  • chromatin silencing at rDNA
  • negative regulation of histone H3-K36 methylation
  • ribosome biogenesis
  • histone peptidyl-prolyl isomerization
  • positive regulation of transcription from RNA polymerase II promoter
  • nucleosome assembly
  • peptidyl-prolyl cis-trans isomerase activity
  • histone binding
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP16
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • PIB2
  • mitochondrion
  • late endosome
  • vesicle-mediated transport
  • phosphatidylinositol binding
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RRP17
  • cytoplasm
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • SCS2
  • integral to membrane
  • endoplasmic reticulum
  • inositol metabolic process
  • protein targeting to ER
  • chromatin silencing at telomere
  • protein binding
  • THI21
  • cellular_component
  • thiamin biosynthetic process
  • hydroxymethylpyrimidine kinase activity
  • phosphomethylpyrimidine kinase activity
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.0691E-15 19 211 13 6292
    nuclear lumen 2.1537E-11 19 453 13 6292
    organelle lumen 2.4845E-9 19 660 13 6292
    intracellular organelle lumen 2.4845E-9 19 660 13 6292
    membrane-enclosed lumen 5.1684E-9 19 700 13 6292
    non-membrane-bounded organelle 1.8386E-8 19 959 14 6292
    intracellular non-membrane-bounded organelle 1.8386E-8 19 959 14 6292
    nuclear part 1.3192E-6 19 1103 13 6292
    nucleus 2.7037E-4 19 2041 14 6292
    preribosome, large subunit precursor 3.0714E-4 19 9 2 6292
    intracellular organelle part 9.9948E-4 19 2282 14 6292
    organelle part 9.9948E-4 19 2282 14 6292
    preribosome 4.5757E-3 19 34 2 6292
    Noc2p-Noc3p complex 6.0308E-3 19 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 3.0075E-16 19 346 15 6292
    ribonucleoprotein complex biogenesis 9.719E-16 19 374 15 6292
    ribosomal large subunit biogenesis 6.4332E-14 19 65 9 6292
    cellular component biogenesis 9.6019E-12 19 694 15 6292
    rRNA processing 5.0323E-8 19 128 7 6292
    rRNA metabolic process 8.0639E-8 19 137 7 6292
    ncRNA processing 1.7524E-6 19 215 7 6292
    ncRNA metabolic process 5.7788E-6 19 257 7 6292
    RNA processing 7.4111E-5 19 380 7 6292
    RNA metabolic process 8.9433E-4 19 954 9 6292
    processing of 27S pre-rRNA 1.011E-3 19 16 2 6292
    cellular process 1.2366E-3 19 4426 19 6292
    establishment of ribosome localization 2.6892E-3 19 26 2 6292
    ribosome localization 2.6892E-3 19 26 2 6292
    ribosomal subunit export from nucleus 2.6892E-3 19 26 2 6292
    negative regulation of histone H3-K36 methylation 3.0197E-3 19 1 1 6292
    regulation of histone H3-K36 methylation 3.0197E-3 19 1 1 6292
    protein peptidyl-prolyl isomerization 3.0197E-3 19 1 1 6292
    histone peptidyl-prolyl isomerization 3.0197E-3 19 1 1 6292
    histone H3-K36 methylation 3.0197E-3 19 1 1 6292
    regulation of histone methylation 3.0197E-3 19 1 1 6292
    negative regulation of histone methylation 3.0197E-3 19 1 1 6292
    negative regulation of histone modification 3.0197E-3 19 1 1 6292
    regulation of histone modification 3.0197E-3 19 1 1 6292
    histone lysine methylation 6.0308E-3 19 2 1 6292
    regulation of chromosome organization 6.0308E-3 19 2 1 6292
    gene expression 7.5132E-3 19 1283 9 6292
    actomyosin structure organization 9.0332E-3 19 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 9.0332E-3 19 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 9.0332E-3 19 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    rRNA binding 1.011E-3 19 16 2 6292
    ribosomal large subunit binding 3.0197E-3 19 1 1 6292
    5S rRNA binding 6.0308E-3 19 2 1 6292
    hydroxymethylpyrimidine kinase activity 6.0308E-3 19 2 1 6292
    binding 7.9644E-3 19 1294 9 6292
    phosphomethylpyrimidine kinase activity 9.0332E-3 19 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle