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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yju2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CCT5
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • COR1
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • DUN1
  • nucleus
  • DNA damage checkpoint
  • cell cycle checkpoint
  • telomere maintenance
  • protein amino acid phosphorylation
  • protein kinase activity
  • EGD1
  • nascent polypeptide-associated complex
  • 'de novo' cotranslational protein folding
  • unfolded protein binding
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • NAP1
  • nucleus
  • cytoplasm
  • nuclear nucleosome
  • M phase of mitotic cell cycle
  • budding cell bud growth
  • nucleosome assembly
  • histone binding
  • NMD3
  • cytosol
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • RNA binding
  • protein binding
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • QCR2
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • SOD1
  • mitochondrial intermembrane space
  • mitochondrion
  • cytosol
  • age-dependent response to reactive oxygen species involved in chronological cell aging
  • response to cold
  • superoxide metabolic process
  • cellular copper ion homeostasis
  • response to drug
  • cellular zinc ion homeostasis
  • antioxidant activity
  • metal ion binding
  • oxidoreductase activity
  • superoxide dismutase activity
  • TCP1
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • YJU2
  • nucleus
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • YNK1
  • mitochondrial intermembrane space
  • mitochondrion
  • cytosol
  • RNA metabolic process
  • purine nucleotide biosynthetic process
  • nucleoside triphosphate biosynthetic process
  • nucleoside diphosphate phosphorylation
  • DNA metabolic process
  • nucleotide metabolic process
  • nucleoside diphosphate kinase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrial respiratory chain complex III 2.0481E-4 14 10 2 6292
    respiratory chain complex III 2.0481E-4 14 10 2 6292
    cytosol 2.5866E-4 14 284 5 6292
    chaperonin-containing T-complex 2.9963E-4 14 12 2 6292
    mitochondrial respiratory chain 1.4494E-3 14 26 2 6292
    respiratory chain 1.4494E-3 14 26 2 6292
    plasma membrane enriched fraction 2.225E-3 14 1 1 6292
    mitochondrial intermembrane space 2.7741E-3 14 36 2 6292
    macromolecular complex 2.8523E-3 14 1635 9 6292
    cytoplasmic part 3.4004E-3 14 2482 11 6292
    organelle envelope lumen 3.4172E-3 14 40 2 6292
    mitochondrial envelope 3.9958E-3 14 312 4 6292
    protein complex 6.4936E-3 14 1137 7 6292
    eukaryotic translation initiation factor 2 complex 6.6614E-3 14 3 1 6292
    nascent polypeptide-associated complex 6.6614E-3 14 3 1 6292
    eukaryotic translation initiation factor 4F complex 8.8726E-3 14 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein folding 6.0468E-4 14 78 3 6292
    nucleoside diphosphate phosphorylation 2.225E-3 14 1 1 6292
    nucleotide phosphorylation 2.225E-3 14 1 1 6292
    superoxide metabolic process 2.225E-3 14 1 1 6292
    translational initiation 3.7625E-3 14 42 2 6292
    cellular metabolic process 4.3936E-3 14 3033 12 6292
    age-dependent response to reactive oxygen species 4.4455E-3 14 2 1 6292
    age-dependent response to reactive oxygen species involved in chronological cell aging 4.4455E-3 14 2 1 6292
    cellular protein metabolic process 4.6722E-3 14 1074 7 6292
    protein metabolic process 6.4609E-3 14 1136 7 6292
    phosphorylation 6.5393E-3 14 179 3 6292
    metabolic process 6.6576E-3 14 3157 12 6292
    nucleoside diphosphate metabolic process 6.6614E-3 14 3 1 6292
    cellular process 7.2188E-3 14 4426 14 6292
    oxygen and reactive oxygen species metabolic process 8.8726E-3 14 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    oxidoreductase activity, acting on diphenols and related substances as donors 1.6406E-4 14 9 2 6292
    oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor 1.6406E-4 14 9 2 6292
    ubiquinol-cytochrome-c reductase activity 1.6406E-4 14 9 2 6292
    unfolded protein binding 2.9253E-4 14 61 3 6292
    binding 4.6837E-4 14 1294 9 6292
    translation initiation factor activity 1.5634E-3 14 27 2 6292
    nucleoside diphosphate kinase activity 2.225E-3 14 1 1 6292
    translation factor activity, nucleic acid binding 4.1234E-3 14 44 2 6292
    superoxide dismutase activity 4.4455E-3 14 2 1 6292
    oxidoreductase activity, acting on superoxide radicals as acceptor 4.4455E-3 14 2 1 6292
    hydrogen ion transmembrane transporter activity 6.1587E-3 14 54 2 6292
    monovalent inorganic cation transmembrane transporter activity 7.3172E-3 14 59 2 6292
    protein binding 8.1355E-3 14 612 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle