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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ycr079w. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC60
  • cytoplasm
  • leucyl-tRNA aminoacylation
  • leucine-tRNA ligase activity
  • DEF1
  • nucleus
  • telomere maintenance
  • response to DNA damage stimulus
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • FAA1
  • lipid particle
  • mitochondrion
  • mitochondrial outer membrane
  • lipid transport
  • lipid metabolic process
  • N-terminal protein myristoylation
  • long-chain fatty acid-CoA ligase activity
  • GDE1
  • cytoplasm
  • ribosome
  • glycerophospholipid catabolic process
  • glycerophosphocholine phosphodiesterase activity
  • HEF3
  • cytosolic ribosome
  • translational elongation
  • ATPase activity
  • translation elongation factor activity
  • KGD1
  • mitochondrial matrix
  • mitochondrial oxoglutarate dehydrogenase complex
  • mitochondrion
  • mitochondrial nucleoid
  • tricarboxylic acid cycle
  • 2-oxoglutarate metabolic process
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
  • MDH1
  • mitochondrial matrix
  • mitochondrion
  • malate metabolic process
  • tricarboxylic acid cycle
  • L-malate dehydrogenase activity
  • PRO2
  • nucleus
  • cytoplasm
  • proline biosynthetic process
  • glutamate-5-semialdehyde dehydrogenase activity
  • PTC6
  • mitochondrial intermembrane space
  • mitochondrion
  • mitochondrion degradation
  • macroautophagy
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • catalytic activity
  • hydrolase activity
  • PYC1
  • cytosol
  • gluconeogenesis
  • NADPH regeneration
  • pyruvate carboxylase activity
  • RAD1
  • nucleotide-excision repair factor 1 complex
  • nucleus
  • nucleotide-excision repair, DNA incision, 5'-to lesion
  • double-strand break repair via single-strand annealing, removal of nonhomologous ends
  • removal of nonhomologous ends
  • meiotic mismatch repair
  • mitotic recombination
  • DNA binding
  • single-stranded DNA specific endodeoxyribonuclease activity
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • TPS1
  • cytoplasm
  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
  • carbohydrate metabolic process
  • response to drug
  • trehalose biosynthetic process
  • response to stress
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    plasma membrane enriched fraction 2.0661E-3 13 1 1 6292
    mitochondrial oxoglutarate dehydrogenase complex 6.1865E-3 13 3 1 6292
    oxoglutarate dehydrogenase complex 6.1865E-3 13 3 1 6292
    nucleotide-excision repair factor 1 complex 6.1865E-3 13 3 1 6292
    alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) 8.2408E-3 13 4 1 6292
    eukaryotic translation initiation factor 4F complex 8.2408E-3 13 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cellular metabolic process 7.4867E-5 13 3033 13 6292
    cellular catabolic process 9.1514E-5 13 415 6 6292
    metabolic process 1.2617E-4 13 3157 13 6292
    catabolic process 2.4729E-4 13 496 6 6292
    organic acid metabolic process 3.6448E-4 13 333 5 6292
    oxoacid metabolic process 3.6448E-4 13 333 5 6292
    carboxylic acid metabolic process 3.6448E-4 13 333 5 6292
    tricarboxylic acid cycle 4.0759E-4 13 15 2 6292
    acetyl-CoA catabolic process 4.0759E-4 13 15 2 6292
    cellular ketone metabolic process 4.3563E-4 13 346 5 6292
    acetyl-CoA metabolic process 7.3325E-4 13 20 2 6292
    coenzyme catabolic process 7.3325E-4 13 20 2 6292
    cofactor catabolic process 8.894E-4 13 22 2 6292
    dicarboxylic acid metabolic process 1.6593E-3 13 30 2 6292
    coenzyme metabolic process 1.6828E-3 13 120 3 6292
    cofactor metabolic process 3.4335E-3 13 154 3 6292
    double-strand break repair via single-strand annealing, removal of nonhomologous ends 4.1283E-3 13 2 1 6292
    nucleotide-excision repair, DNA incision, 5'-to lesion 4.1283E-3 13 2 1 6292
    mitochondrion degradation 4.1283E-3 13 2 1 6292
    leucyl-tRNA aminoacylation 4.1283E-3 13 2 1 6292
    2-oxoglutarate metabolic process 4.1283E-3 13 2 1 6292
    nucleotide-excision repair, DNA incision 6.1865E-3 13 3 1 6292
    phospholipid catabolic process 6.1865E-3 13 3 1 6292
    proline biosynthetic process 6.1865E-3 13 3 1 6292
    glycerophospholipid catabolic process 6.1865E-3 13 3 1 6292
    macroautophagy 8.2408E-3 13 4 1 6292
    malate metabolic process 8.2408E-3 13 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    catalytic activity 2.2136E-5 13 2150 12 6292
    oxidoreductase activity, acting on the aldehyde or oxo group of donors 1.151E-3 13 25 2 6292
    glutamate-5-semialdehyde dehydrogenase activity 2.0661E-3 13 1 1 6292
    glycerophosphocholine phosphodiesterase activity 2.0661E-3 13 1 1 6292
    ligase activity 3.1865E-3 13 150 3 6292
    translation factor activity, nucleic acid binding 3.5501E-3 13 44 2 6292
    pyruvate carboxylase activity 4.1283E-3 13 2 1 6292
    oxoglutarate dehydrogenase (succinyl-transferring) activity 4.1283E-3 13 2 1 6292
    leucine-tRNA ligase activity 4.1283E-3 13 2 1 6292
    alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 6.1865E-3 13 3 1 6292
    L-malate dehydrogenase activity 8.2408E-3 13 4 1 6292
    ligase activity, forming carbon-carbon bonds 8.2408E-3 13 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle