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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ubc6. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ATP4
  • mitochondrial proton-transporting ATP synthase, stator stalk
  • mitochondrion
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • GCN1
  • mitochondrion
  • cytosol
  • regulation of translational elongation
  • molecular_function
  • LOS1
  • mitochondrion
  • nuclear matrix
  • tRNA export from nucleus
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • tRNA binding
  • Ran GTPase binding
  • POL5
  • nucleolus
  • DNA replication
  • rRNA transcription
  • DNA-directed DNA polymerase activity
  • RVB1
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • chromatin remodeling complex
  • chromatin remodeling
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • SEC7
  • late endosome
  • cytosol
  • Golgi-associated vesicle
  • ER to Golgi vesicle-mediated transport
  • intra-Golgi vesicle-mediated transport
  • ARF guanyl-nucleotide exchange factor activity
  • TMA19
  • cytoplasm
  • mitochondrion
  • cytosol
  • ribosome
  • response to oxidative stress
  • translation
  • molecular_function
  • UBA1
  • nucleus
  • cytoplasm
  • ubiquitin cycle
  • ubiquitin activating enzyme activity
  • UBC6
  • endoplasmic reticulum membrane
  • protein polyubiquitination
  • ER-associated protein catabolic process
  • protein monoubiquitination
  • ubiquitin-protein ligase activity
  • UTP20
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA processing
  • snoRNA binding
  • YPT1
  • endoplasmic reticulum membrane
  • mitochondrion
  • Golgi membrane
  • ER to Golgi vesicle-mediated transport
  • protein complex assembly
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear matrix 3.4937E-3 11 2 1 6292
    nuclear periphery 3.4937E-3 11 2 1 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    mitochondrial proton-transporting ATP synthase, stator stalk 5.2364E-3 11 3 1 6292
    proton-transporting ATP synthase, stator stalk 5.2364E-3 11 3 1 6292
    nuclear membrane-endoplasmic reticulum network 6.5547E-3 11 232 3 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ncRNA 5'-end processing 5.2364E-3 11 3 1 6292
    endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 5.2364E-3 11 3 1 6292
    rRNA 5'-end processing 5.2364E-3 11 3 1 6292
    rRNA transcription 5.2364E-3 11 3 1 6292
    RNA 5'-end processing 5.2364E-3 11 3 1 6292
    endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 5.2364E-3 11 3 1 6292
    maturation of 5.8S rRNA 6.9763E-3 11 4 1 6292
    cleavage involved in rRNA processing 6.9763E-3 11 4 1 6292
    maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 6.9763E-3 11 4 1 6292
    endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 6.9763E-3 11 4 1 6292
    endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 6.9763E-3 11 4 1 6292
    endonucleolytic cleavage involved in rRNA processing 6.9763E-3 11 4 1 6292
    ubiquitin cycle 6.9763E-3 11 4 1 6292
    ER to Golgi vesicle-mediated transport 8.7534E-3 11 83 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin activating enzyme activity 1.7483E-3 11 1 1 6292
    Ran GTPase binding 6.9763E-3 11 4 1 6292
    tRNA binding 8.7135E-3 11 5 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle