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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 19 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
AIM1
  • cellular_component
    		•
  • biological_process
    		•
  • molecular_function
    		•
    CFT1
  • mRNA cleavage and polyadenylation specificity factor complex
  • mitochondrion
  • mRNA cleavage factor complex
    		•
  • termination of RNA polymerase II transcription
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
    		•
    CFT2
  • mRNA cleavage and polyadenylation specificity factor complex
  • mRNA cleavage factor complex
    		•
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
    		•
    ECM21
  • cytoplasm
    		•
  • cellular cell wall organization
    		•
  • molecular_function
    		•
    FIP1
  • mRNA cleavage and polyadenylation specificity factor complex
    		•
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
  • protein binding
    		•
    GIP4
  • cytoplasm
    		•
  • chromosome segregation
  • regulation of phosphoprotein phosphatase activity
    		•
  • protein phosphatase type 1 regulator activity
  • protein phosphatase 1 binding
    		•
    MPE1
  • mRNA cleavage and polyadenylation specificity factor complex
    		•
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
    		•
    PAP1
  • mRNA cleavage and polyadenylation specificity factor complex
  • nucleoplasm
    		•
  • mRNA export from nucleus
  • mRNA polyadenylation
    		•
  • polynucleotide adenylyltransferase activity
    		•
    PFS2
  • mRNA cleavage and polyadenylation specificity factor complex
    		•
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
    		•
    PTA1
  • mRNA cleavage and polyadenylation specificity factor complex
  • mRNA cleavage factor complex
    		•
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • tRNA processing
  • termination of RNA polymerase II transcription, poly(A)-independent
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
    		•
    PTI1
  • nucleus
  • mRNA cleavage and polyadenylation specificity factor complex
    		•
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • termination of RNA polymerase II transcription, poly(A)-independent
  • mRNA polyadenylation
  • mRNA cleavage
  • snoRNA 3'-end processing
    		•
  • RNA binding
    		•
    REF2
  • nucleus
  • mRNA cleavage and polyadenylation specificity factor complex
    		•
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • termination of RNA polymerase II transcription, poly(A)-independent
  • telomere maintenance
  • mRNA processing
  • snoRNA 3'-end processing
    		•
  • DNA binding
  • RNA binding
    		•
    SSU72
  • nucleus
  • mRNA cleavage and polyadenylation specificity factor complex
  • nuclear outer membrane
    		•
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • termination of RNA polymerase II transcription, poly(A)-independent
  • snoRNA transcription
  • termination of RNA polymerase II transcription
  • transcription initiation from RNA polymerase II promoter
    		•
  • phosphoprotein phosphatase activity
  • RNA binding
  • protein tyrosine phosphatase activity
  • phosphoric ester hydrolase activity
    		•
    SWD2
  • Set1C/COMPASS complex
  • mRNA cleavage and polyadenylation specificity factor complex
    		•
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • termination of RNA polymerase II transcription, poly(A)-independent
  • histone methylation
  • telomere maintenance
  • mRNA 3'-end processing
  • snoRNA 3'-end processing
    		•
  • histone methyltransferase activity (H3-K4 specific)
    		•
    SYC1
  • nucleus
  • mRNA cleavage and polyadenylation specificity factor complex
    		•
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • termination of RNA polymerase II transcription, poly(A)-independent
    		•
  • RNA binding
    		•
    YBL010C
  • clathrin-coated vesicle
    		•
  • biological_process
    		•
  • molecular_function
    		•
    YLR358C
    YSH1
  • mRNA cleavage and polyadenylation specificity factor complex
  • mRNA cleavage factor complex
    		•
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
  • endoribonuclease activity
    		•
    YTH1
  • mRNA cleavage and polyadenylation specificity factor complex
    		•
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    mRNA cleavage and polyadenylation specificity factor complex 1.0114E-37 19 15 14 6292
    mRNA cleavage factor complex 2.6038E-34 19 20 14 6292
    nucleoplasm part 1.2498E-16 19 245 14 6292
    nucleoplasm 3.6028E-16 19 264 14 6292
    nuclear lumen 6.9103E-13 19 453 14 6292
    organelle lumen 1.2105E-10 19 660 14 6292
    intracellular organelle lumen 1.2105E-10 19 660 14 6292
    membrane-enclosed lumen 2.6909E-10 19 700 14 6292
    nuclear part 1.1639E-7 19 1103 14 6292
    protein complex 1.7319E-7 19 1137 14 6292
    macromolecular complex 1.8064E-5 19 1635 14 6292
    nucleus 2.7037E-4 19 2041 14 6292
    intracellular organelle part 9.9948E-4 19 2282 14 6292
    organelle part 9.9948E-4 19 2282 14 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA 3'-end processing 6.792E-23 19 42 12 6292
    mRNA polyadenylation 3.1697E-22 19 19 10 6292
    mRNA 3'-end processing 4.1141E-22 19 31 11 6292
    RNA polyadenylation 1.806E-20 19 26 10 6292
    mRNA cleavage 4.3552E-18 19 25 9 6292
    mRNA processing 1.5327E-15 19 156 12 6292
    nucleic acid phosphodiester bond hydrolysis 2.2788E-15 19 46 9 6292
    termination of RNA polymerase II transcription, poly(A)-independent 2.6368E-14 19 9 6 6292
    termination of RNA polymerase II transcription 3.2233E-14 19 19 7 6292
    termination of RNA polymerase II transcription, poly(A)-coupled 6.5804E-14 19 10 6 6292
    mRNA metabolic process 6.8196E-14 19 213 12 6292
    transcription termination 7.4134E-14 19 21 7 6292
    cellular protein complex disassembly 9.5146E-12 19 39 7 6292
    protein complex disassembly 9.5146E-12 19 39 7 6292
    cellular macromolecular complex disassembly 1.1514E-11 19 40 7 6292
    macromolecular complex disassembly 1.1514E-11 19 40 7 6292
    cellular component disassembly 2.3507E-11 19 44 7 6292
    RNA processing 6.8182E-11 19 380 12 6292
    RNA metabolic process 1.7153E-8 19 954 14 6292
    snoRNA metabolic process 1.7699E-7 19 18 4 6292
    snoRNA 3'-end processing 2.3263E-7 19 5 3 6292
    snoRNA processing 8.1108E-7 19 7 3 6292
    gene expression 8.3168E-7 19 1283 14 6292
    nucleic acid metabolic process 2.92E-6 19 1415 14 6292
    ncRNA 3'-end processing 5.0498E-6 19 12 3 6292
    cellular macromolecular complex subunit organization 6.084E-6 19 259 7 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0532E-5 19 1566 14 6292
    transcription from RNA polymerase II promoter 3.292E-5 19 335 7 6292
    cellular nitrogen compound metabolic process 4.8231E-5 19 1770 14 6292
    macromolecular complex subunit organization 4.965E-5 19 357 7 6292
    nitrogen compound metabolic process 5.5743E-5 19 1791 14 6292
    transcription, DNA-dependent 4.3096E-4 19 503 7 6292
    RNA biosynthetic process 4.5798E-4 19 508 7 6292
    transcription 7.6015E-4 19 552 7 6292
    ncRNA metabolic process 7.9353E-4 19 257 5 6292
    cellular macromolecule metabolic process 1.0147E-3 19 2285 14 6292
    macromolecule metabolic process 1.3926E-3 19 2349 14 6292
    snoRNA transcription 3.0197E-3 19 1 1 6292
    ncRNA processing 3.4298E-3 19 215 4 6292
    cellular metabolic process 6.2064E-3 19 3033 15 6292
    regulation of dephosphorylation 9.0332E-3 19 3 1 6292
    regulation of phosphatase activity 9.0332E-3 19 3 1 6292
    regulation of phosphoprotein phosphatase activity 9.0332E-3 19 3 1 6292
    metabolic process 9.9095E-3 19 3157 15 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA binding 4.5254E-11 19 367 12 6292
    nucleic acid binding 4.4984E-8 19 666 12 6292
    binding 8.6671E-6 19 1294 13 6292
    phosphatase binding 9.0332E-3 19 3 1 6292
    protein phosphatase binding 9.0332E-3 19 3 1 6292
    protein phosphatase 1 binding 9.0332E-3 19 3 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle