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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 420.50
Complex Size: 18 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
ATP1
  • mitochondrion
  • mitochondrial proton-transporting ATP synthase, catalytic core
  • mitochondrial nucleoid
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP14
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP15
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP16
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP17
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP18
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP19
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP2
  • soluble fraction
  • mitochondrion
  • mitochondrial proton-transporting ATP synthase, catalytic core
    		•
  • age-dependent general metabolic decline involved in replicative cell aging
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP20
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • structural molecule activity
    		•
    ATP3
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP4
  • mitochondrial proton-transporting ATP synthase, stator stalk
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP5
  • mitochondrial proton-transporting ATP synthase, stator stalk
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP6
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP7
  • mitochondrial proton-transporting ATP synthase, stator stalk
  • mitochondrion
    		•
  • protein complex assembly
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    ATP8
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    INH1
  • mitochondrion
  • mitochondrial proton-transporting ATP synthase complex
    		•
  • ATP synthesis coupled proton transport
    		•
  • enzyme inhibitor activity
    		•
    OLI1
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•
    TIM11
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrion
    		•
  • ATP synthesis coupled proton transport
    		•
  • structural molecule activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    mitochondrial proton-transporting ATP synthase complex 5.2176E-51 18 20 18 6292
    proton-transporting ATP synthase complex 5.2176E-51 18 20 18 6292
    proton-transporting two-sector ATPase complex 1.2461E-43 18 35 18 6292
    mitochondrial membrane part 8.4207E-34 18 100 18 6292
    mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) 2.334E-33 18 12 12 6292
    proton-transporting ATP synthase complex, coupling factor F(o) 2.334E-33 18 12 12 6292
    mitochondrial inner membrane 3.6889E-29 18 174 18 6292
    proton-transporting two-sector ATPase complex, proton-transporting domain 1.1688E-28 18 19 12 6292
    organelle inner membrane 1.176E-28 18 185 18 6292
    mitochondrial membrane 1.0587E-25 18 266 18 6292
    mitochondrial envelope 2.0421E-24 18 312 18 6292
    mitochondrial part 4.6905E-21 18 475 18 6292
    envelope 1.4404E-20 18 505 18 6292
    organelle envelope 1.4404E-20 18 505 18 6292
    membrane part 2.0256E-18 18 662 18 6292
    organelle membrane 4.544E-18 18 692 18 6292
    mitochondrion 3.1171E-14 18 1125 18 6292
    protein complex 3.7785E-14 18 1137 18 6292
    membrane 9.7467E-14 18 1198 18 6292
    proton-transporting ATP synthase complex, catalytic core F(1) 1.0443E-13 18 5 5 6292
    mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) 1.0443E-13 18 5 5 6292
    macromolecular complex 2.7221E-11 18 1635 18 6292
    proton-transporting two-sector ATPase complex, catalytic domain 1.3255E-10 18 13 5 6292
    intracellular organelle part 1.1294E-8 18 2282 18 6292
    organelle part 1.1294E-8 18 2282 18 6292
    mitochondrial proton-transporting ATP synthase, central stalk 1.9664E-8 18 3 3 6292
    mitochondrial proton-transporting ATP synthase, stator stalk 1.9664E-8 18 3 3 6292
    proton-transporting ATP synthase, stator stalk 1.9664E-8 18 3 3 6292
    proton-transporting ATP synthase, central stalk 1.9664E-8 18 3 3 6292
    cytoplasmic part 5.1519E-8 18 2482 18 6292
    mitochondrial proton-transporting ATP synthase, catalytic core 7.7306E-6 18 2 2 6292
    proton-transporting ATP synthase, catalytic core 7.7306E-6 18 2 2 6292
    cytoplasm 3.3277E-5 18 3552 18 6292
    membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular organelle 3.879E-4 18 4070 18 6292
    organelle 3.8963E-4 18 4071 18 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    ATP synthesis coupled proton transport 5.2176E-51 18 20 18 6292
    energy coupled proton transport, down electrochemical gradient 5.2176E-51 18 20 18 6292
    ATP metabolic process 5.2176E-51 18 20 18 6292
    ATP biosynthetic process 5.2176E-51 18 20 18 6292
    purine ribonucleoside triphosphate biosynthetic process 2.0088E-49 18 22 18 6292
    purine nucleoside triphosphate biosynthetic process 2.0088E-49 18 22 18 6292
    proton transport 3.6961E-48 18 24 18 6292
    ribonucleoside triphosphate biosynthetic process 3.6961E-48 18 24 18 6292
    hydrogen transport 3.6961E-48 18 24 18 6292
    purine ribonucleoside triphosphate metabolic process 1.287E-46 18 27 18 6292
    purine nucleoside triphosphate metabolic process 1.287E-46 18 27 18 6292
    nucleoside triphosphate biosynthetic process 1.287E-46 18 27 18 6292
    ribonucleoside triphosphate metabolic process 9.5007E-46 18 29 18 6292
    monovalent inorganic cation transport 5.6639E-45 18 31 18 6292
    ion transmembrane transport 1.2946E-44 18 32 18 6292
    nucleoside triphosphate metabolic process 6.0523E-44 18 34 18 6292
    purine ribonucleotide biosynthetic process 9.7128E-42 18 42 18 6292
    ribonucleotide biosynthetic process 4.712E-41 18 45 18 6292
    oxidative phosphorylation 7.7411E-41 18 46 18 6292
    purine nucleotide biosynthetic process 3.1729E-40 18 49 18 6292
    purine ribonucleotide metabolic process 1.1718E-39 18 52 18 6292
    ribonucleotide metabolic process 3.9566E-39 18 55 18 6292
    purine nucleotide metabolic process 1.2357E-38 18 58 18 6292
    nucleotide biosynthetic process 6.3699E-37 18 70 18 6292
    transmembrane transport 2.0519E-35 18 83 18 6292
    nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 1.0407E-34 18 90 18 6292
    nucleobase, nucleoside and nucleotide biosynthetic process 1.0407E-34 18 90 18 6292
    cation transport 3.0518E-34 18 95 18 6292
    ion transport 2.9843E-32 18 120 18 6292
    nucleotide metabolic process 1.0414E-31 18 128 18 6292
    nucleoside phosphate metabolic process 1.0414E-31 18 128 18 6292
    nucleobase, nucleoside and nucleotide metabolic process 5.2321E-30 18 157 18 6292
    heterocycle metabolic process 2.6531E-29 18 171 18 6292
    phosphorylation 6.3065E-29 18 179 18 6292
    generation of precursor metabolites and energy 3.1737E-28 18 195 18 6292
    phosphorus metabolic process 6.4798E-27 18 229 18 6292
    phosphate metabolic process 6.4798E-27 18 229 18 6292
    cellular nitrogen compound biosynthetic process 2.6626E-26 18 247 18 6292
    small molecule biosynthetic process 1.813E-24 18 310 18 6292
    small molecule metabolic process 2.5056E-17 18 760 18 6292
    transport 3.4821E-15 18 997 18 6292
    establishment of localization 4.2497E-15 18 1008 18 6292
    localization 1.0589E-14 18 1060 18 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.2475E-11 18 1566 18 6292
    cellular biosynthetic process 1.262E-11 18 1567 18 6292
    biosynthetic process 1.8822E-11 18 1602 18 6292
    cellular nitrogen compound metabolic process 1.1435E-10 18 1770 18 6292
    nitrogen compound metabolic process 1.4154E-10 18 1791 18 6292
    primary metabolic process 8.3514E-7 18 2896 18 6292
    cellular metabolic process 1.9237E-6 18 3033 18 6292
    metabolic process 3.9649E-6 18 3157 18 6292
    cellular process 1.7601E-3 18 4426 18 6292
    age-dependent general metabolic decline involved in replicative cell aging 2.8608E-3 18 1 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    hydrogen ion transporting ATP synthase activity, rotational mechanism 1.1314E-42 18 15 15 6292
    hydrogen ion transmembrane transporter activity 9.6213E-30 18 54 15 6292
    monovalent inorganic cation transmembrane transporter activity 4.4253E-29 18 59 15 6292
    inorganic cation transmembrane transporter activity 3.2381E-25 18 101 15 6292
    cation transmembrane transporter activity 3.9067E-24 18 118 15 6292
    ion transmembrane transporter activity 1.1309E-22 18 146 15 6292
    substrate-specific transmembrane transporter activity 1.2907E-18 18 267 15 6292
    transmembrane transporter activity 1.0318E-17 18 306 15 6292
    substrate-specific transporter activity 4.2705E-17 18 336 15 6292
    transporter activity 6.928E-16 18 404 15 6292
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