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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 4 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
HAT1
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
    		•
  • histone acetylation
  • chromatin silencing at telomere
    		•
  • histone binding
    		•
    HAT2
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
    		•
  • chromatin assembly or disassembly
  • histone acetylation
  • chromatin silencing at telomere
    		•
  • histone binding
    		•
    HIF1
  • nucleus
  • histone acetyltransferase complex
    		•
  • histone acetylation
  • chromatin silencing at telomere
  • nucleosome assembly
    		•
  • histone binding
    		•
    ORC2
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone acetyltransferase complex 1.2704E-6 4 44 3 6292
    nucleoplasm part 2.2451E-6 4 245 4 6292
    nucleoplasm 3.0322E-6 4 264 4 6292
    nuclear lumen 2.6539E-5 4 453 4 6292
    organelle lumen 1.2008E-4 4 660 4 6292
    intracellular organelle lumen 1.2008E-4 4 660 4 6292
    membrane-enclosed lumen 1.5203E-4 4 700 4 6292
    nuclear part 9.4015E-4 4 1103 4 6292
    protein complex 1.0617E-3 4 1137 4 6292
    origin recognition complex 3.8098E-3 4 6 1 6292
    nuclear origin of replication recognition complex 3.8098E-3 4 6 1 6292
    macromolecular complex 4.5471E-3 4 1635 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    negative regulation of gene expression, epigenetic 6.0102E-8 4 100 4 6292
    chromatin silencing 6.0102E-8 4 100 4 6292
    gene silencing 6.0102E-8 4 100 4 6292
    regulation of gene expression, epigenetic 6.0102E-8 4 100 4 6292
    negative regulation of transcription, DNA-dependent 3.7337E-7 4 157 4 6292
    negative regulation of RNA metabolic process 3.8306E-7 4 158 4 6292
    negative regulation of gene expression 4.4528E-7 4 164 4 6292
    negative regulation of transcription 4.4528E-7 4 164 4 6292
    negative regulation of macromolecule biosynthetic process 5.7866E-7 4 175 4 6292
    negative regulation of nitrogen compound metabolic process 6.483E-7 4 180 4 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6.483E-7 4 180 4 6292
    histone acetylation 6.8555E-7 4 36 3 6292
    negative regulation of biosynthetic process 7.8928E-7 4 189 4 6292
    negative regulation of cellular biosynthetic process 7.8928E-7 4 189 4 6292
    negative regulation of macromolecule metabolic process 8.4103E-7 4 192 4 6292
    negative regulation of cellular metabolic process 1.1839E-6 4 209 4 6292
    negative regulation of metabolic process 1.2069E-6 4 210 4 6292
    protein amino acid acetylation 1.4558E-6 4 46 3 6292
    negative regulation of cellular process 2.4353E-6 4 250 4 6292
    chromatin silencing at telomere 2.5132E-6 4 55 3 6292
    negative regulation of biological process 2.555E-6 4 253 4 6292
    protein amino acid acylation 3.1128E-6 4 59 3 6292
    regulation of transcription, DNA-dependent 1.0315E-5 4 358 4 6292
    covalent chromatin modification 1.0471E-5 4 88 3 6292
    histone modification 1.0471E-5 4 88 3 6292
    regulation of RNA metabolic process 1.0906E-5 4 363 4 6292
    regulation of transcription 1.367E-5 4 384 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.867E-5 4 415 4 6292
    regulation of nitrogen compound metabolic process 1.8852E-5 4 416 4 6292
    regulation of gene expression 2.4707E-5 4 445 4 6292
    regulation of macromolecule biosynthetic process 2.7251E-5 4 456 4 6292
    regulation of cellular biosynthetic process 3.1296E-5 4 472 4 6292
    regulation of biosynthetic process 3.1563E-5 4 473 4 6292
    regulation of macromolecule metabolic process 3.5776E-5 4 488 4 6292
    transcription, DNA-dependent 4.0396E-5 4 503 4 6292
    RNA biosynthetic process 4.2031E-5 4 508 4 6292
    regulation of primary metabolic process 4.4059E-5 4 514 4 6292
    regulation of cellular metabolic process 5.2125E-5 4 536 4 6292
    regulation of metabolic process 5.655E-5 4 547 4 6292
    transcription 5.8652E-5 4 552 4 6292
    chromatin modification 7.3351E-5 4 168 3 6292
    chromatin organization 1.2926E-4 4 203 3 6292
    chromatin assembly or disassembly 1.7912E-4 4 35 2 6292
    protein-DNA complex assembly 2.2288E-4 4 39 2 6292
    regulation of cellular process 2.5447E-4 4 796 4 6292
    regulation of biological process 2.9228E-4 4 824 4 6292
    RNA metabolic process 5.2568E-4 4 954 4 6292
    post-translational protein modification 6.9425E-4 4 357 3 6292
    cellular macromolecule biosynthetic process 1.2614E-3 4 1187 4 6292
    macromolecule biosynthetic process 1.27E-3 4 1189 4 6292
    biological regulation 1.3758E-3 4 1213 4 6292
    gene expression 1.7224E-3 4 1283 4 6292
    protein modification process 1.8668E-3 4 499 3 6292
    nucleic acid metabolic process 2.5494E-3 4 1415 4 6292
    chromosome organization 2.5518E-3 4 555 3 6292
    macromolecule modification 2.7453E-3 4 569 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.8261E-3 4 1566 4 6292
    cellular biosynthetic process 3.8359E-3 4 1567 4 6292
    cellular component organization 3.9851E-3 4 1582 4 6292
    biosynthetic process 4.1907E-3 4 1602 4 6292
    cellular macromolecular complex assembly 4.8049E-3 4 182 2 6292
    cellular nitrogen compound metabolic process 6.2471E-3 4 1770 4 6292
    nitrogen compound metabolic process 6.5492E-3 4 1791 4 6292
    pre-replicative complex assembly 8.2408E-3 4 13 1 6292
    cellular macromolecular complex subunit organization 9.5855E-3 4 259 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone binding 3.5042E-8 4 14 3 6292
    binding 1.7823E-3 4 1294 4 6292
    protein binding 3.3984E-3 4 612 3 6292
    DNA replication origin binding 8.2408E-3 4 13 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle