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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 16 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
DST1
  • nucleoplasm
    		•
  • reciprocal meiotic recombination
  • RNA elongation from RNA polymerase II promoter
  • mRNA cleavage
    		•
  • positive transcription elongation factor activity
    		•
    IWR1
  • nucleus
  • cytoplasm
  • DNA-directed RNA polymerase II, holoenzyme
    		•
  • transcription from RNA polymerase II promoter
  • meiosis
    		•
  • molecular_function
    		•
    RPB10
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB11
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB2
  • mitochondrion
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB3
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB4
  • nucleus
  • cytoplasm
  • cytoplasmic mRNA processing body
  • DNA-directed RNA polymerase II, core complex
    		•
  • mRNA export from nucleus
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB5
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB7
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB8
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB9
  • DNA-directed RNA polymerase II, core complex
    		•
  • response to drug
  • transcription-coupled nucleotide-excision repair
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • response to DNA damage stimulus
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPO21
  • mitochondrion
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPO26
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    SPT5
  • nucleus
  • transcription elongation factor complex
  • DSIF complex
  • mitochondrion
    		•
  • regulation of transcription, DNA-dependent
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    TFG1
  • transcription factor TFIIF complex
    		•
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFG2
  • transcription factor TFIIF complex
    		•
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    DNA-directed RNA polymerase II, core complex 3.4469E-30 16 12 11 6292
    DNA-directed RNA polymerase II, holoenzyme 3.9919E-28 16 56 14 6292
    RNA polymerase complex 2.3986E-23 16 31 11 6292
    nuclear DNA-directed RNA polymerase complex 2.3986E-23 16 31 11 6292
    DNA-directed RNA polymerase complex 2.3986E-23 16 31 11 6292
    nucleoplasm 5.9149E-23 16 264 16 6292
    nucleoplasm part 7.2768E-21 16 245 15 6292
    nuclear lumen 4.0631E-19 16 453 16 6292
    organelle lumen 1.823E-16 16 660 16 6292
    intracellular organelle lumen 1.823E-16 16 660 16 6292
    membrane-enclosed lumen 4.7232E-16 16 700 16 6292
    nuclear part 7.2679E-13 16 1103 16 6292
    protein complex 8.8311E-11 16 1137 15 6292
    nucleus 1.444E-8 16 2041 16 6292
    macromolecular complex 1.9232E-8 16 1635 15 6292
    DNA-directed RNA polymerase I complex 2.75E-8 16 14 4 6292
    DNA-directed RNA polymerase III complex 6.5086E-8 16 17 4 6292
    organelle part 8.6662E-8 16 2282 16 6292
    intracellular organelle part 8.6662E-8 16 2282 16 6292
    nucleolar part 3.9036E-6 16 45 4 6292
    transcription factor TFIIF complex 1.8163E-5 16 3 2 6292
    membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular organelle 9.2974E-4 16 4070 16 6292
    organelle 9.334E-4 16 4071 16 6292
    nucleolus 1.6283E-3 16 211 4 6292
    DSIF complex 5.0798E-3 16 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription from RNA polymerase II promoter 2.9537E-21 16 335 16 6292
    transcription, DNA-dependent 2.2288E-18 16 503 16 6292
    RNA biosynthetic process 2.6172E-18 16 508 16 6292
    transcription 1.0078E-17 16 552 16 6292
    RNA metabolic process 7.0068E-14 16 954 16 6292
    cellular macromolecule biosynthetic process 2.3702E-12 16 1187 16 6292
    macromolecule biosynthetic process 2.4353E-12 16 1189 16 6292
    gene expression 8.2892E-12 16 1283 16 6292
    nucleic acid metabolic process 4.0069E-11 16 1415 16 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0462E-10 16 1566 16 6292
    cellular biosynthetic process 2.0673E-10 16 1567 16 6292
    biosynthetic process 2.9487E-10 16 1602 16 6292
    cellular nitrogen compound metabolic process 1.4646E-9 16 1770 16 6292
    nitrogen compound metabolic process 1.7702E-9 16 1791 16 6292
    cellular macromolecule metabolic process 8.851E-8 16 2285 16 6292
    macromolecule metabolic process 1.379E-7 16 2349 16 6292
    transcription from RNA polymerase I promoter 7.3469E-7 16 30 4 6292
    transcription from RNA polymerase III promoter 1.9548E-6 16 38 4 6292
    primary metabolic process 3.9666E-6 16 2896 16 6292
    cellular metabolic process 8.3256E-6 16 3033 16 6292
    metabolic process 1.5832E-5 16 3157 16 6292
    cellular process 3.565E-3 16 4426 16 6292
    RNA elongation from RNA polymerase II promoter 4.2529E-3 16 39 2 6292
    transcription-coupled nucleotide-excision repair 5.0798E-3 16 2 1 6292
    RNA elongation 5.6318E-3 16 45 2 6292
    transcription initiation from RNA polymerase II promoter 6.1313E-3 16 47 2 6292
    transcription initiation 9.2242E-3 16 58 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA polymerase activity 8.0867E-23 16 34 11 6292
    DNA-directed RNA polymerase activity 8.0867E-23 16 34 11 6292
    nucleotidyltransferase activity 1.3811E-14 16 168 11 6292
    transferase activity, transferring phosphorus-containing groups 3.3284E-10 16 420 11 6292
    transferase activity 3.0144E-7 16 797 11 6292
    transcription elongation regulator activity 1.011E-3 16 19 2 6292
    positive transcription elongation factor activity 2.5429E-3 16 1 1 6292
    catalytic activity 4.9755E-3 16 2150 11 6292
    transcription regulator activity 8.9888E-3 16 339 4 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle