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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL16B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS1A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS26B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 4.797E-21 17 101 13 6292
    cytosolic part 6.3752E-20 17 122 13 6292
    ribosomal subunit 1.4992E-17 17 183 13 6292
    cytosol 4.9973E-15 17 284 13 6292
    ribosome 6.5721E-15 17 290 13 6292
    cytosolic large ribosomal subunit 9.5956E-13 17 60 8 6292
    ribonucleoprotein complex 1.0968E-11 17 514 13 6292
    large ribosomal subunit 1.4408E-10 17 110 8 6292
    non-membrane-bounded organelle 2.9132E-8 17 959 13 6292
    intracellular non-membrane-bounded organelle 2.9132E-8 17 959 13 6292
    cytosolic small ribosomal subunit 3.5916E-8 17 38 5 6292
    small ribosomal subunit 1.0163E-6 17 73 5 6292
    macromolecular complex 1.8944E-5 17 1635 13 6292
    cytoplasm 8.3722E-4 17 3552 16 6292
    organelle part 8.5928E-4 17 2282 13 6292
    intracellular organelle part 8.5928E-4 17 2282 13 6292
    90S preribosome 9.1252E-4 17 17 2 6292
    cytoplasmic part 2.1458E-3 17 2482 13 6292
    stress granule 2.7018E-3 17 1 1 6292
    preribosome 3.6639E-3 17 34 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 3.1367E-19 17 376 16 6292
    cellular macromolecule biosynthetic process 4.4224E-13 17 1187 17 6292
    macromolecule biosynthetic process 4.5517E-13 17 1189 17 6292
    gene expression 1.6734E-12 17 1283 17 6292
    cellular protein metabolic process 6.767E-12 17 1074 16 6292
    protein metabolic process 1.6528E-11 17 1136 16 6292
    cellular biosynthetic process 5.109E-11 17 1567 17 6292
    biosynthetic process 7.4517E-11 17 1602 17 6292
    cellular macromolecule metabolic process 3.1999E-8 17 2285 17 6292
    macromolecule metabolic process 5.1262E-8 17 2349 17 6292
    primary metabolic process 1.8202E-6 17 2896 17 6292
    cellular metabolic process 4.0023E-6 17 3033 17 6292
    metabolic process 7.9234E-6 17 3157 17 6292
    regulation of translation 1.3198E-5 17 57 4 6292
    posttranscriptional regulation of gene expression 1.732E-5 17 61 4 6292
    regulation of cellular protein metabolic process 2.6716E-5 17 68 4 6292
    regulation of protein metabolic process 3.7372E-5 17 74 4 6292
    ribosomal small subunit biogenesis 2.1497E-3 17 26 2 6292
    cellular process 2.5051E-3 17 4426 17 6292
    negative regulation of mRNA processing 2.7018E-3 17 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 2.7018E-3 17 1 1 6292
    negative regulation of RNA splicing 2.7018E-3 17 1 1 6292
    regulation of gene expression 5.2502E-3 17 445 5 6292
    regulation of mRNA processing 5.3968E-3 17 2 1 6292
    regulation of RNA splicing 5.3968E-3 17 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 5.3968E-3 17 2 1 6292
    regulation of macromolecule biosynthetic process 5.8282E-3 17 456 5 6292
    regulation of cellular biosynthetic process 6.749E-3 17 472 5 6292
    regulation of biosynthetic process 6.8098E-3 17 473 5 6292
    regulation of macromolecule metabolic process 7.7699E-3 17 488 5 6292
    ribosomal subunit assembly 9.3809E-3 17 55 2 6292
    regulation of primary metabolic process 9.6568E-3 17 514 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 2.5971E-23 17 212 16 6292
    structural molecule activity 5.8026E-20 17 339 16 6292
    RNA binding 2.267E-3 17 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle