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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL18A, RPL18B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL24A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL29
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL8B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • translation
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • YHI9
  • cellular_component
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 1.0671E-21 20 101 14 6292
    cytosolic part 1.7453E-20 20 122 14 6292
    cytosolic large ribosomal subunit 3.5509E-18 20 60 11 6292
    ribosomal subunit 6.2828E-18 20 183 14 6292
    cytosol 3.2354E-15 20 284 14 6292
    large ribosomal subunit 4.1338E-15 20 110 11 6292
    ribosome 4.341E-15 20 290 14 6292
    ribonucleoprotein complex 4.194E-13 20 514 15 6292
    non-membrane-bounded organelle 5.2702E-8 20 959 14 6292
    intracellular non-membrane-bounded organelle 5.2702E-8 20 959 14 6292
    macromolecular complex 6.1762E-6 20 1635 15 6292
    cytosolic small ribosomal subunit 2.1587E-4 20 38 3 6292
    cytoplasm 1.38E-3 20 3552 18 6292
    small ribosomal subunit 1.4825E-3 20 73 3 6292
    organelle part 2.2217E-3 20 2282 14 6292
    intracellular organelle part 2.2217E-3 20 2282 14 6292
    stress granule 3.1786E-3 20 1 1 6292
    cytoplasmic part 5.5174E-3 20 2482 14 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 1.0882E-20 20 376 18 6292
    cellular macromolecule biosynthetic process 2.5292E-13 20 1187 19 6292
    macromolecule biosynthetic process 2.6111E-13 20 1189 19 6292
    gene expression 1.1008E-12 20 1283 19 6292
    cellular protein metabolic process 1.8036E-12 20 1074 18 6292
    protein metabolic process 4.8817E-12 20 1136 18 6292
    cellular biosynthetic process 4.7706E-11 20 1567 19 6292
    biosynthetic process 7.2256E-11 20 1602 19 6292
    cellular macromolecule metabolic process 5.4899E-8 20 2285 19 6292
    macromolecule metabolic process 9.1608E-8 20 2349 19 6292
    regulation of translation 7.1326E-7 20 57 5 6292
    posttranscriptional regulation of gene expression 1.0054E-6 20 61 5 6292
    regulation of cellular protein metabolic process 1.7371E-6 20 68 5 6292
    regulation of protein metabolic process 2.6524E-6 20 74 5 6292
    primary metabolic process 4.3236E-6 20 2896 19 6292
    cellular metabolic process 1.0049E-5 20 3033 19 6292
    metabolic process 2.082E-5 20 3157 19 6292
    ribosomal subunit assembly 6.4857E-4 20 55 3 6292
    ribosome assembly 1.0114E-3 20 64 3 6292
    organelle assembly 1.259E-3 20 69 3 6292
    regulation of gene expression 1.9953E-3 20 445 6 6292
    regulation of macromolecule biosynthetic process 2.2618E-3 20 456 6 6292
    regulation of cellular biosynthetic process 2.6974E-3 20 472 6 6292
    regulation of biosynthetic process 2.7266E-3 20 473 6 6292
    ribonucleoprotein complex assembly 2.8802E-3 20 92 3 6292
    ribosomal small subunit biogenesis 2.9805E-3 20 26 2 6292
    response to cycloalkane 3.1786E-3 20 1 1 6292
    response to organic cyclic substance 3.1786E-3 20 1 1 6292
    negative regulation of mRNA processing 3.1786E-3 20 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 3.1786E-3 20 1 1 6292
    negative regulation of RNA splicing 3.1786E-3 20 1 1 6292
    response to cycloheximide 3.1786E-3 20 1 1 6292
    regulation of macromolecule metabolic process 3.1943E-3 20 488 6 6292
    ribosome biogenesis 3.8143E-3 20 346 5 6292
    regulation of primary metabolic process 4.1467E-3 20 514 6 6292
    regulation of cellular metabolic process 5.1082E-3 20 536 6 6292
    ribonucleoprotein complex biogenesis 5.3273E-3 20 374 5 6292
    regulation of metabolic process 5.6474E-3 20 547 6 6292
    regulation of mRNA processing 6.3477E-3 20 2 1 6292
    regulation of RNA splicing 6.3477E-3 20 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 6.3477E-3 20 2 1 6292
    ribosomal large subunit assembly 7.3084E-3 20 41 2 6292
    cellular process 8.2259E-3 20 4426 19 6292
    response to antibiotic 9.5071E-3 20 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 2.7348E-25 20 212 18 6292
    structural molecule activity 1.6296E-21 20 339 18 6292
    RNA binding 4.9144E-3 20 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle