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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 18 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
NHP6A
  • nuclear chromatin
  • chromatin remodeling
  • chromatin organization
  • positive regulation of transcription from RNA polymerase II promoter
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase II promoter
  • chromatin binding
  • PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL29
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL8B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • translation
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • YHI9
  • cellular_component
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 2.5709E-18 18 101 12 6292
    cytosolic part 2.7473E-17 18 122 12 6292
    ribosomal subunit 4.0816E-15 18 183 12 6292
    cytosolic large ribosomal subunit 1.5888E-14 18 60 9 6292
    cytosol 8.298E-13 18 284 12 6292
    ribosome 1.0658E-12 18 290 12 6292
    large ribosomal subunit 4.6756E-12 18 110 9 6292
    ribonucleoprotein complex 9.1955E-10 18 514 12 6292
    non-membrane-bounded organelle 9.0245E-8 18 959 13 6292
    intracellular non-membrane-bounded organelle 9.0245E-8 18 959 13 6292
    cytosolic small ribosomal subunit 1.5581E-4 18 38 3 6292
    macromolecular complex 3.3568E-4 18 1635 12 6292
    small ribosomal subunit 1.079E-3 18 73 3 6292
    organelle part 2.0665E-3 18 2282 13 6292
    intracellular organelle part 2.0665E-3 18 2282 13 6292
    stress granule 2.8608E-3 18 1 1 6292
    cytoplasm 3.5545E-3 18 3552 16 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.3434E-16 18 376 15 6292
    cellular macromolecule biosynthetic process 6.5585E-12 18 1187 17 6292
    macromolecule biosynthetic process 6.7478E-12 18 1189 17 6292
    gene expression 2.4382E-11 18 1283 17 6292
    cellular biosynthetic process 7.0508E-10 18 1567 17 6292
    biosynthetic process 1.0213E-9 18 1602 17 6292
    cellular protein metabolic process 1.3657E-9 18 1074 15 6292
    protein metabolic process 3.0826E-9 18 1136 15 6292
    cellular macromolecule metabolic process 3.7937E-7 18 2285 17 6292
    macromolecule metabolic process 5.9885E-7 18 2349 17 6292
    primary metabolic process 1.8567E-5 18 2896 17 6292
    cellular metabolic process 3.9339E-5 18 3033 17 6292
    metabolic process 7.5219E-5 18 3157 17 6292
    ribosomal subunit assembly 4.7003E-4 18 55 3 6292
    regulation of translation 5.2235E-4 18 57 3 6292
    posttranscriptional regulation of gene expression 6.3791E-4 18 61 3 6292
    ribosome assembly 7.3452E-4 18 64 3 6292
    regulation of cellular protein metabolic process 8.7722E-4 18 68 3 6292
    organelle assembly 9.1545E-4 18 69 3 6292
    regulation of protein metabolic process 1.1225E-3 18 74 3 6292
    ribonucleoprotein complex assembly 2.1056E-3 18 92 3 6292
    ribosome biogenesis 2.3083E-3 18 346 5 6292
    ribosomal small subunit biogenesis 2.4123E-3 18 26 2 6292
    response to cycloalkane 2.8608E-3 18 1 1 6292
    response to organic cyclic substance 2.8608E-3 18 1 1 6292
    negative regulation of mRNA processing 2.8608E-3 18 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 2.8608E-3 18 1 1 6292
    negative regulation of RNA splicing 2.8608E-3 18 1 1 6292
    response to cycloheximide 2.8608E-3 18 1 1 6292
    ribonucleoprotein complex biogenesis 3.2481E-3 18 374 5 6292
    regulation of mRNA processing 5.7138E-3 18 2 1 6292
    regulation of RNA splicing 5.7138E-3 18 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 5.7138E-3 18 2 1 6292
    ribosomal large subunit assembly 5.9338E-3 18 41 2 6292
    regulation of gene expression 6.8545E-3 18 445 5 6292
    regulation of macromolecule biosynthetic process 7.598E-3 18 456 5 6292
    response to antibiotic 8.5592E-3 18 3 1 6292
    regulation of cellular biosynthetic process 8.7795E-3 18 472 5 6292
    regulation of biosynthetic process 8.8575E-3 18 473 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 3.7416E-20 18 212 15 6292
    structural molecule activity 4.8866E-17 18 339 15 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle