YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • CUS1
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • protein binding
  • DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • LEA1
  • cytoplasm
  • U2 snRNP
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP11
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • PRP21
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP3
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • PRP9
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SNU23
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • zinc ion binding
  • metal ion binding
  • molecular_function
  • SNU66
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nuclear ribonucleoprotein complex 2.4519E-44 21 63 21 6292
    U4/U6 x U5 tri-snRNP complex 3.122E-29 21 32 14 6292
    ribonucleoprotein complex 9.7798E-24 21 514 21 6292
    U5 snRNP 9.9643E-18 21 14 8 6292
    nuclear part 1.1242E-16 21 1103 21 6292
    U2 snRNP 2.5544E-15 21 13 7 6292
    macromolecular complex 4.6538E-13 21 1635 21 6292
    nucleus 5.0329E-11 21 2041 21 6292
    organelle part 5.3026E-10 21 2282 21 6292
    intracellular organelle part 5.3026E-10 21 2282 21 6292
    U1 snRNP 2.1227E-7 21 17 4 6292
    membrane-bounded organelle 2.0956E-5 21 3771 21 6292
    intracellular membrane-bounded organelle 2.0956E-5 21 3771 21 6292
    intracellular organelle 1.0447E-4 21 4070 21 6292
    organelle 1.0501E-4 21 4071 21 6292
    commitment complex 6.8633E-4 21 12 2 6292
    U2-type spliceosomal complex 6.8633E-4 21 12 2 6292
    intracellular part 6.1098E-3 21 4938 21 6292
    intracellular 7.149E-3 21 4975 21 6292
    spliceosomal complex 9.6347E-3 21 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 1.432E-39 21 99 21 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.8126E-39 21 100 21 6292
    RNA splicing, via transesterification reactions 8.7967E-39 21 107 21 6292
    RNA splicing 1.1022E-36 21 132 21 6292
    mRNA processing 4.825E-35 21 156 21 6292
    mRNA metabolic process 4.9352E-32 21 213 21 6292
    RNA processing 1.4824E-26 21 380 21 6292
    RNA metabolic process 5.1781E-18 21 954 21 6292
    gene expression 2.7621E-15 21 1283 21 6292
    nucleic acid metabolic process 2.1931E-14 21 1415 21 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.871E-13 21 1566 21 6292
    cellular nitrogen compound metabolic process 2.4869E-12 21 1770 21 6292
    nitrogen compound metabolic process 3.1903E-12 21 1791 21 6292
    cellular macromolecule metabolic process 5.4516E-10 21 2285 21 6292
    macromolecule metabolic process 9.7623E-10 21 2349 21 6292
    spliceosome assembly 2.0671E-9 21 18 5 6292
    ribonucleoprotein complex assembly 1.117E-8 21 92 7 6292
    primary metabolic process 8.0566E-8 21 2896 21 6292
    cellular metabolic process 2.1337E-7 21 3033 21 6292
    metabolic process 4.9632E-7 21 3157 21 6292
    cellular macromolecular complex assembly 1.246E-6 21 182 7 6292
    cellular macromolecular complex subunit organization 1.3078E-5 21 259 7 6292
    macromolecular complex assembly 2.2284E-5 21 281 7 6292
    macromolecular complex subunit organization 1.0378E-4 21 357 7 6292
    ribonucleoprotein complex biogenesis 1.3923E-4 21 374 7 6292
    cellular component assembly 1.6705E-4 21 385 7 6292
    spliceosomal conformational changes to generate catalytic conformation 3.7663E-4 21 9 2 6292
    cellular process 6.1031E-4 21 4426 21 6292
    regulation of hormone levels 3.3376E-3 21 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 3.3376E-3 21 1 1 6292
    auxin biosynthetic process 3.3376E-3 21 1 1 6292
    auxin metabolic process 3.3376E-3 21 1 1 6292
    hormone metabolic process 3.3376E-3 21 1 1 6292
    hormone biosynthetic process 3.3376E-3 21 1 1 6292
    cellular component biogenesis 5.5911E-3 21 694 7 6292
    nuclear mRNA 3'-splice site recognition 6.6645E-3 21 2 1 6292
    generation of catalytic spliceosome for first transesterification step 9.9809E-3 21 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 9.1897E-15 21 367 15 6292
    nucleic acid binding 5.9805E-11 21 666 15 6292
    binding 4.9395E-9 21 1294 17 6292
    snRNA binding 3.1914E-7 21 5 3 6292
    U5 snRNA binding 1.0611E-5 21 2 2 6292
    mRNA binding 1.9584E-4 21 35 3 6292
    U2 snRNA binding 3.3376E-3 21 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle