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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC23
  • spliceosomal complex
  • biological_process
  • molecular_function
  • ECM2
  • nucleus
  • cellular cell wall organization
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • LEA1
  • cytoplasm
  • U2 snRNP
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SNT309
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SYF1
  • spliceosomal complex
  • cell cycle
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    spliceosomal complex 4.5334E-13 12 45 7 6292
    ribonucleoprotein complex 1.0889E-11 12 514 11 6292
    nuclear part 4.6507E-8 12 1103 11 6292
    nucleus 1.3278E-6 12 2041 12 6292
    U2 snRNP 1.5001E-6 12 13 3 6292
    macromolecular complex 3.2574E-6 12 1635 11 6292
    small nuclear ribonucleoprotein complex 4.2552E-6 12 63 4 6292
    organelle part 1.1283E-4 12 2282 11 6292
    intracellular organelle part 1.1283E-4 12 2282 11 6292
    membrane-bounded organelle 2.1329E-3 12 3771 12 6292
    intracellular membrane-bounded organelle 2.1329E-3 12 3771 12 6292
    intracellular organelle 5.3355E-3 12 4070 12 6292
    organelle 5.3513E-3 12 4071 12 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 3.7654E-17 12 99 10 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4.1826E-17 12 100 10 6292
    RNA splicing, via transesterification reactions 8.4726E-17 12 107 10 6292
    RNA splicing 7.4695E-16 12 132 10 6292
    mRNA processing 4.1645E-15 12 156 10 6292
    mRNA metabolic process 9.9889E-14 12 213 10 6292
    RNA processing 3.8587E-13 12 380 11 6292
    RNA metabolic process 9.5918E-9 12 954 11 6292
    gene expression 2.393E-7 12 1283 11 6292
    nucleic acid metabolic process 6.8885E-7 12 1415 11 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0509E-6 12 1566 11 6292
    cellular nitrogen compound metabolic process 7.6146E-6 12 1770 11 6292
    nitrogen compound metabolic process 8.6368E-6 12 1791 11 6292
    cellular macromolecule metabolic process 1.144E-4 12 2285 11 6292
    macromolecule metabolic process 1.5296E-4 12 2349 11 6292
    spliceosome assembly 5.0164E-4 12 18 2 6292
    ribonucleoprotein complex assembly 6.0496E-4 12 92 3 6292
    primary metabolic process 1.3504E-3 12 2896 11 6292
    cellular metabolic process 2.1697E-3 12 3033 11 6292
    metabolic process 3.2647E-3 12 3157 11 6292
    ribonucleoprotein complex biogenesis 4.1497E-3 12 374 4 6292
    cellular macromolecular complex assembly 4.3192E-3 12 182 3 6292
    generation of catalytic spliceosome for first transesterification step 5.7116E-3 12 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    snRNA binding 3.3242E-5 12 5 2 6292
    RNA binding 3.6987E-4 12 367 5 6292
    U2 snRNA binding 1.9072E-3 12 1 1 6292
    U5 snRNA binding 3.811E-3 12 2 1 6292
    nucleic acid binding 5.4944E-3 12 666 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle