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Protein Overview: SST2

General Information:
Name(s) found: SST2 / YLR452C [SGD]
Description(s) found:
Found 24 descriptions.
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  • GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 698 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: signal transduction [IMPLink to PubMed article]
    adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: GTPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDKNRTLHE LSSKNFSRTP NGLIFTNDLK TVYSIFLICL DLKEKKHSSD TKSFLLTAFT  60
   61 KHFHFTFTYQ EAIKAMGQLE LKVDMNTTCI NVSYNIKPSL ARHLLTLFMS SKLLHTPQDR 120
  121 TRGEPKEKVL FQPTPKGVAV LQKYVRDIGL KTMPDILLSS FNSMKLFTFE RSSVTDSIIH 180
  181 SDYLIHILFI KMMGAKPNVW SPTNADDPLP CLSSLLEYTN NDDTFTFEKS KPEQGWQAQI 240
  241 GNIDINDLER VSPLAHRFFT NPDSESHTQY YVSNAGIRLF ENKTFGTSKK IVIKYTFTTK 300
  301 AIWQWIMDCT DIMHVKEAVS LAALFLKTGL IVPVLLQPSR TDKKKFQISR SSFFTLSKRG 360
  361 WDLVSWTGCK SNNIRAPNGS TIDLDFTLRG HMTVRDEKKT LDDSEGFSQD MLISSSNLNK 420
  421 LDYVLTDPGM RYLFRRHLEK ELCVENLDVF IEIKRFLKKM TILKKLIDSK HCDKKSNTST 480
  481 SKNNIVKTID SALMKQANEC LEMAYHIYSS YIMIGSPYQL NIHHNLRQNI SDIMLHPHSP 540
  541 LSEHFPTNLY DPSPASAESA ASSISSTEAD TLGEPPEVSL KPSKNLSNEN CSFKKQGFKH 600
  601 QLKEYKPAPL TLAETHSPNA SVENSHTIVR YGMDNTQNDT KSVESFPATL KVLRKLYPLF 660
  661 EIVSNEMYRL MNNDSFQKFT QSDVYKDASA LIEIQEKC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) AMN1 AXL2 IMH1 PEX19 PFK27 RAX2 RGT2 RIC1 RIX7 RPA190 SST2 TRX1 TRX2 YLR035C-A
    View Details Krogan NJ, et al. (2006) EGT2 SST2 YEL025C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RIX7 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SST2 SHO1 2 Unpublished Fields Lab Data
    View Screen SST2 VPS36 2 Unpublished Fields Lab Data
    View Screen SST2 YER188W 2 Unpublished Fields Lab Data
    View Screen SST2 NBP1 2 Unpublished Fields Lab Data
    View Screen SST2 MCM6 2 Unpublished Fields Lab Data
    View Screen SST2 YMD8 2 Unpublished Fields Lab Data
    View Screen SST2 PET494 2 Unpublished Fields Lab Data
    View Screen SST2 YGR018C 2 Unpublished Fields Lab Data
    View Screen SST2 MVP1 2 Unpublished Fields Lab Data
    View Screen SST2 KIN3 2 Unpublished Fields Lab Data
    View Screen SST2 KSS1 2 Unpublished Fields Lab Data
    View Screen SST2 YIP1 2 Unpublished Fields Lab Data
    View Screen SST2 YBR137W 2 Unpublished Fields Lab Data
    View Screen SST2 KEL1 2 Unpublished Fields Lab Data
    View Screen SST2 TLG2 2 Unpublished Fields Lab Data
    View Screen SST2 ATG7 2 Unpublished Fields Lab Data
    View Screen SST2 YCL056C 2 Unpublished Fields Lab Data
    View Screen SST2 BNR1 2 Unpublished Fields Lab Data
    View Screen SST2 PEP12 2 Unpublished Fields Lab Data
    View Screen SST2 FMP41 2 Unpublished Fields Lab Data
    View Screen SST2 YDL180W 2 Unpublished Fields Lab Data
    View Screen SST2 MPS3 2 Unpublished Fields Lab Data
    View Screen SST2 FRT1 2 Unpublished Fields Lab Data
    View Screen SST2 YNL203C 2 Unpublished Fields Lab Data
    View Screen SST2 YDL186W 2 Unpublished Fields Lab Data
    View Screen SST2 IKS1 2 Unpublished Fields Lab Data
    View Screen SST2 FOB1 2 Unpublished Fields Lab Data
    View Screen SST2 UME1 2 Unpublished Fields Lab Data
    View Screen SST2 YFT2 2 Unpublished Fields Lab Data
    View Screen SST2 FAL1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SST2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] MSA 2.00494 View MSA. No confident structure predictions are available.
    2 View Details [218..277] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [278..356] Pfam 15.920819 Domain found in Dishevelled, Egl-10, and Pleckstrin No confident structure predictions are available.
    4 View Details [357..610] PSI-BLAST 48.69897 Regulator of G-protein signalling 4, RGS4
    5 View Details [611..698] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA binding
    		•  3.26215136954128 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.20757869683617 bayes_pls_golite062009
  • binding
    		•  2.73671056234733 bayes_pls_golite062009
  • transcription factor activity
    		•  2.55529689278984 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.05637852290839 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.01485346767161 bayes_pls_golite062009
  • signal transducer activity
    		•  0.992792292243706 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.992792292243706 bayes_pls_golite062009
  • transcription activator activity
    		•  0.897659561486815 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.803693565413327 bayes_pls_golite062009
  • protein binding
    		•  0.726445167461826 bayes_pls_golite062009
  • receptor binding
    		•  0.108282618387842 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.0824467927265171 bayes_pls_golite062009
    3
    Term Confidence Notes
  • GTPase regulator activity
    		•  1.83884232402739 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.81253255528145 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.79347668842628 bayes_pls_golite062009
  • binding
    		•  1.71250041369331 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.54570017870363 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.39953365194488 bayes_pls_golite062009
  • protein binding
    		•  1.34804002381061 bayes_pls_golite062009
  • signal transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.41692824983039 bayes_pls_golite062009
  • I-SMAD binding
    		•  0.255267853221551 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle