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View Structure Prediction Details

Protein: SST2
Organism: Saccharomyces cerevisiae
Length: 698 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SST2.

Description E-value Query
Range
Subject
Range
SST2_YEAST - Protein SST2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SST2 PE=1 SV=2
SST2 - GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also requi...
0.0 [1..698] [1..698]
gi|8745527 - gi|8745527|gb|AAF78951.1|AF267870_1 putative regulator of G protein signaling Thn1; RGS [Schizophyll...
0.0 [11..562] [11..505]
gi|189442420 - gi|189442420|gb|AAI67850.1| Regulator of G-protein signaling 12 [synthetic construct]
RGS12 - regulator of G-protein signaling 12
5.0E-67 [335..625] [637..913]
AXIN1_RAT - Axin-1 OS=Rattus norvegicus GN=Axin1 PE=1 SV=3
1.0E-61 [377..632] [111..361]
AXIN1_MOUSE, AXN... - Axin-1 OS=Mus musculus GN=Axin1 PE=1 SV=2, Axin-1 OS=Mus musculus GN=Axin1 PE=1 SV=2
2.0E-61 [377..632] [174..424]

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Predicted Domain #1
Region A:
Residues: [1-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDKNRTLHE LSSKNFSRTP NGLIFTNDLK TVYSIFLICL DLKEKKHSSD TKSFLLTAFT  60
   61 KHFHFTFTYQ EAIKAMGQLE LKVDMNTTCI NVSYNIKPSL ARHLLTLFMS SKLLHTPQDR 120
  121 TRGEPKEKVL FQPTPKGVAV LQKYVRDIGL KTMPDILLSS FNSMKLFTFE RSSVTDSIIH 180
  181 SDYLIHILFI KMMGAKPNVW SPTNADDPLP CLSSLLE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [218-277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTNNDDTFTF EKSKPEQGWQ AQIGNIDIND LERVSPLAHR FFTNPDSESH TQYYVSNAGI  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.369 0.800 GTPase activator activity d.211.1 Ankyrin repeat

Predicted functions:

Term Confidence Notes
DNA binding 3.26215136954128 bayes_pls_golite062009
nucleic acid binding 3.20757869683617 bayes_pls_golite062009
binding 2.73671056234733 bayes_pls_golite062009
transcription factor activity 2.55529689278984 bayes_pls_golite062009
transcription regulator activity 2.05637852290839 bayes_pls_golite062009
sequence-specific DNA binding 1.01485346767161 bayes_pls_golite062009
signal transducer activity 0.992792292243706 bayes_pls_golite062009
molecular transducer activity 0.992792292243706 bayes_pls_golite062009
transcription activator activity 0.897659561486815 bayes_pls_golite062009
transcription repressor activity 0.803693565413327 bayes_pls_golite062009
protein binding 0.726445167461826 bayes_pls_golite062009
receptor binding 0.108282618387842 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.0824467927265171 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [278-356]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLFENKTFGT SKKIVIKYTF TTKAIWQWIM DCTDIMHVKE AVSLAALFLK TGLIVPVLLQ  60
   61 PSRTDKKKFQ ISRSSFFTL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 15.920819
Match: PF00610
Description: Domain found in Dishevelled, Egl-10, and Pleckstrin

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.83884232402739 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.81253255528145 bayes_pls_golite062009
GTPase activator activity 1.79347668842628 bayes_pls_golite062009
binding 1.71250041369331 bayes_pls_golite062009
enzyme activator activity 1.54570017870363 bayes_pls_golite062009
enzyme regulator activity 1.39953365194488 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
signal transducer activity 1.14361809679544 bayes_pls_golite062009
molecular transducer activity 1.14361809679544 bayes_pls_golite062009
beta-catenin binding 0.41692824983039 bayes_pls_golite062009
I-SMAD binding 0.255267853221551 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [357-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKRGWDLVSW TGCKSNNIRA PNGSTIDLDF TLRGHMTVRD EKKTLDDSEG FSQDMLISSS  60
   61 NLNKLDYVLT DPGMRYLFRR HLEKELCVEN LDVFIEIKRF LKKMTILKKL IDSKHCDKKS 120
  121 NTSTSKNNIV KTIDSALMKQ ANECLEMAYH IYSSYIMIGS PYQLNIHHNL RQNISDIMLH 180
  181 PHSPLSEHFP TNLYDPSPAS AESAASSISS TEADTLGEPP EVSLKPSKNL SNENCSFKKQ 240
  241 GFKHQLKEYK PAPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.69897
Match: 1agrE_
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [611-698]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLAETHSPNA SVENSHTIVR YGMDNTQNDT KSVESFPATL KVLRKLYPLF EIVSNEMYRL  60
   61 MNNDSFQKFT QSDVYKDASA LIEIQEKC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle