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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 24 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BUD22
  • nucleus
  • cellular bud site selection
  • ribosome biogenesis
  • molecular_function
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP6
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • EFG1
  • nucleolus
  • biological_process
  • molecular_function
  • FRE3
  • integral to membrane
  • plasma membrane
  • cellular iron ion homeostasis
  • siderophore-iron transport
  • ferric-chelate reductase activity
  • GIS2
  • cytoplasm
  • intracellular signaling pathway
  • response to water
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOB1
  • nucleus
  • preribosome
  • maturation of SSU-rRNA
  • ribosomal small subunit biogenesis
  • ribosome biogenesis
  • proteasome assembly
  • RNA binding
  • protein binding
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOP1
  • nuclear outer membrane
  • nucleolus
  • ribosome
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • RNA methylation
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • snoRNA 3'-end processing
  • methyltransferase activity
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP8
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • PUS7
  • nucleus
  • pseudouridine synthesis
  • snRNA modification
  • ribosome biogenesis
  • tRNA modification
  • pseudouridine synthase activity
  • RRP5
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • snoRNA binding
  • rRNA primary transcript binding
  • RSA3
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal large subunit assembly
  • molecular_function
  • SBP1
  • nuclear outer membrane
  • nucleolus
  • negative regulation of translation in response to stress
  • response to stress
  • snoRNA binding
  • SFA1
  • cytoplasm
  • mitochondrion
  • formaldehyde catabolic process
  • formaldehyde dehydrogenase (glutathione) activity
  • alcohol dehydrogenase (NAD) activity
  • SSQ1
  • mitochondrial matrix
  • mitochondrion
  • DNA-dependent DNA replication
  • intracellular sequestering of iron ion
  • unfolded protein binding
  • YGR272C
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • molecular_function
  • YMR034C
  • cellular_component
  • biological_process
  • sterol transporter activity
  • YRF1-8, YRF1-5, ...
  • nucleus
  • cellular_component
  • biological_process
  • telomere maintenance via recombination
  • nucleotide binding
  • nucleic acid binding
  • ATP binding
  • DNA helicase activity
  • ATP-dependent helicase activity
  • helicase activity
  • hydrolase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 2.1637E-15 24 211 14 6292
    preribosome, large subunit precursor 6.4617E-11 24 9 5 6292
    nuclear lumen 8.3205E-11 24 453 14 6292
    organelle lumen 9.3317E-10 24 660 15 6292
    intracellular organelle lumen 9.3317E-10 24 660 15 6292
    preribosome 1.9654E-9 24 34 6 6292
    membrane-enclosed lumen 2.1451E-9 24 700 15 6292
    Noc complex 4.8532E-7 24 5 3 6292
    nuclear part 1.1164E-6 24 1103 15 6292
    non-membrane-bounded organelle 1.4599E-6 24 959 14 6292
    intracellular non-membrane-bounded organelle 1.4599E-6 24 959 14 6292
    nucleus 3.3252E-6 24 2041 19 6292
    Noc2p-Noc3p complex 1.3945E-5 24 2 2 6292
    Noc1p-Noc2p complex 1.3945E-5 24 2 2 6292
    nuclear outer membrane 1.4701E-5 24 86 5 6292
    nuclear membrane 2.6455E-5 24 97 5 6292
    nuclear envelope 7.7575E-5 24 199 6 6292
    ribonucleoprotein complex 4.262E-4 24 514 8 6292
    outer membrane 4.7013E-4 24 178 5 6292
    organelle outer membrane 4.7013E-4 24 178 5 6292
    nucleolar part 6.23E-4 24 45 3 6292
    nuclear membrane-endoplasmic reticulum network 1.5613E-3 24 232 5 6292
    90S preribosome 1.8314E-3 24 17 2 6292
    intracellular organelle part 2.3613E-3 24 2282 16 6292
    organelle part 2.3613E-3 24 2282 16 6292
    endomembrane system 3.1255E-3 24 398 6 6292
    membrane-bounded organelle 3.3895E-3 24 3771 21 6292
    intracellular membrane-bounded organelle 3.3895E-3 24 3771 21 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 7.8742E-14 24 346 15 6292
    ribonucleoprotein complex biogenesis 2.4893E-13 24 374 15 6292
    cellular component biogenesis 1.8997E-9 24 694 15 6292
    ribosome assembly 2.4321E-9 24 64 7 6292
    ribosomal large subunit biogenesis 2.7191E-9 24 65 7 6292
    organelle assembly 4.1739E-9 24 69 7 6292
    ribosomal large subunit assembly 6.4584E-9 24 41 6 6292
    rRNA processing 1.3184E-8 24 128 8 6292
    rRNA metabolic process 2.2576E-8 24 137 8 6292
    ribonucleoprotein complex assembly 3.2081E-8 24 92 7 6292
    ribosomal subunit assembly 4.0226E-8 24 55 6 6292
    ncRNA processing 4.4998E-8 24 215 9 6292
    cellular macromolecular complex assembly 2.0801E-7 24 182 8 6292
    ncRNA metabolic process 2.1013E-7 24 257 9 6292
    cellular macromolecular complex subunit organization 3.0663E-6 24 259 8 6292
    macromolecular complex assembly 5.6404E-6 24 281 8 6292
    RNA processing 5.6472E-6 24 380 9 6292
    macromolecular complex subunit organization 3.2725E-5 24 357 8 6292
    cellular component assembly 5.6367E-5 24 385 8 6292
    maturation of SSU-rRNA 1.3781E-3 24 59 3 6292
    negative regulation of translation in response to stress 3.8144E-3 24 1 1 6292
    snRNA modification 3.8144E-3 24 1 1 6292
    regulation of translation in response to stress 3.8144E-3 24 1 1 6292
    RNA metabolic process 6.2133E-3 24 954 9 6292
    intracellular sequestering of iron ion 7.6148E-3 24 2 1 6292
    formaldehyde catabolic process 7.6148E-3 24 2 1 6292
    formaldehyde metabolic process 7.6148E-3 24 2 1 6292
    sequestering of metal ion 7.6148E-3 24 2 1 6292
    iron ion homeostasis 9.0157E-3 24 38 2 6292
    cellular iron ion homeostasis 9.0157E-3 24 38 2 6292
    nucleic acid metabolic process 9.5021E-3 24 1415 11 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent helicase activity 7.5368E-4 24 48 3 6292
    purine NTP-dependent helicase activity 7.5368E-4 24 48 3 6292
    helicase activity 3.6683E-3 24 83 3 6292
    sterol transporter activity 3.8144E-3 24 1 1 6292
    formaldehyde dehydrogenase (glutathione) activity 3.8144E-3 24 1 1 6292
    ATP-dependent RNA helicase activity 4.9616E-3 24 28 2 6292
    RNA-dependent ATPase activity 5.3167E-3 24 29 2 6292
    snoRNA binding 6.0611E-3 24 31 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle