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Protein Overview: HTZ1

General Information:
Name(s) found: HTZ1 / YOL012C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 134 amino acids

    Gene Ontology:
    Cellular Component: chromatin assembly complex [IPILink to PubMed article]
    nuclear chromatin [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    Biological Process: chromatin silencing at silent mating-type cassette [IGILink to PubMed article][IPILink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: chromatin binding [IDALink to PubMed article][IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGKAHGGKG KSGAKDSGSL RSQSSSARAG LQFPVGRIKR YLKRHATGRT RVGSKAAIYL  60
   61 TAVLEYLTAE VLELAGNAAK DLKVKRITPR HLQLAIRGDD ELDSLIRATI ASGGVLPHIN 120
  121 KALLLKVEKK GSKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABF2 HTZ1 KAP114 NAP1 RPL17A RPS16B, RPS16A
    View Details Krogan NJ, et al. (2006) GIN4 HFD1 HTZ1 KAP114 KCC4 NAP1 PRO3 REI1 RIM11 RPS6A, RPS6B UBC8 VIP1 WTM1 YKR011C
    View Details Gavin AC, et al. (2002) GIN4 HTZ1 KAP114 KCC4 LYS12 NAP1 NBA1 NIS1 SSC1 YRA1
    View Details Ho Y, et al. (2002) GND1 HHF1, HHF2 HTB2 HTZ1 RAD16 RAD7 SHP1 TMA29 TSA2
    View Details Qiu et al. (2008) ABF1 HHF1, HHF2 HTZ1 PCC1 POB3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HTZ1 MPS3 2 Uetz P, et al. (2000)
    View Screen NIT2 HTZ1 2 Unpublished Fields Lab Data
    View Screen REH1 HTZ1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HTZ1 and NOP56 Huh WK, et al. (2003)
    View Data HTZ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] PSI-BLAST 363.201249 Histone H2A
    2 View Details [67..134] PSI-BLAST 363.201249 Histone H2A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.581886805340955 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle