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Protein Overview: IF5A1_RAT

General Information:
Name(s) found: IF5A1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|91207082|sp|Q3T1J1.3|IF5A1_RAT RecName: Full=Eukaryotic translation initiation factor 5A-1; Short=eIF-5A-1; Short=eIF-5A1; AltName: Full=Eukaryotic initiation factor 5A isoform 1; Short=eIF-5A; AltName: Full=eIF-4D [NCBI NR]
  • gi|76096304|ref|NP_001028853.1| eukaryotic translation initiation factor 5A [Rattus norvegicus] [NCBI NR]
  • gi|74353711|gb|AAI01892.1| Eukaryotic translation initiation factor 5A [Rattus norvegicus] [NCBI NR]
  • ref|XP_213368.1| similar to Eukaryotic translation initiation factor 5A (eIF-5A) (eIF-4D) (Rev-binding factor) [Rattus norvegicus] [NCBI NR]
  • gi|149053116|gb|EDM04933.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053115|gb|EDM04932.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053114|gb|EDM04931.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053113|gb|EDM04930.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053112|gb|EDM04929.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053111|gb|EDM04928.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053110|gb|EDM04927.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053109|gb|EDM04926.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053108|gb|EDM04925.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053105|gb|EDM04922.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|149053104|gb|EDM04921.1| rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • Eukaryotic translation initiation factor 5A-1 OS=Rattus norvegicus GN=Eif5a PE=1 SV=3 [Swiss-Prot]
  • similar to Eukaryotic translation initiation factor 5A (eIF-5A) (eIF-4D) (Rev-binding factor) [HMR_022704-rand.fasta]
  • similar to Eukaryotic translation initiation factor 5A (eIF-5A) (eIF-4D) (Rev-binding factor) [Rattus norvegicus]gi|54673799|gb|AAH85015.1| Eukaryotic translation initiation factor 5A [Homo sapiens]gi|51036244|ref|NP_001003658.1| eukaryotic translation [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Eukaryotic translation initiation factor 5A [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • Tax_Id=10116 PREDICTED: similar to eukaryotic translation initiation factor 5A [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta]
  • Tax_Id=10116 Similar to Eukaryotic tranSlation initiation factor 5A (eIF-5A) (eIF-4D) (Rev-binding factor) [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta]
  • Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • eukaryotic translation initiation factor 5A [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • rCG32592, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Eukaryotic translation initiation factor 5A [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SIMILAR TO EUKARYOTIC TRANSLATION INITIATION FACTOR 5A (EIF-5A) (EIF-4D) (REV-BINDING FACTOR) [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Eif5a Eukaryotic translation initiation factor 5A-1 [rat-ipi-250309-contam.fasta]
  • Eukaryotic translation initiation factor 5A-1 OS=Rattus norvegicus GN=Eif5a [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 154 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IEA]
    nucleus [UNKNOWN][IEA]
    dendrite [IDA]
    cytoplasm [UNKNOWN][IEA]
    membrane [IEA]
    cytosol [UNKNOWN]
    endoplasmic reticulum [IEA]
    neuronal cell body [IDA]
    annulate lamellae [UNKNOWN]
    nuclear pore [UNKNOWN][IEA]
    Biological Process: positive regulation of translational termination [IEA]
    transmembrane transport [IEA]
    positive regulation of cell proliferation [UNKNOWN]
    protein transport [IEA]
    translational frameshifting [IEA]
    protein export from nucleus [UNKNOWN]
    aging [IEP]
    positive regulation of translational elongation [IEA]
    peptidyl-lysine modification to hypusine [UNKNOWN][IEA]
    translation [IEA]
    mRNA export from nucleus [UNKNOWN]
    [NOT]nucleocytoplasmic transport [UNKNOWN]
    induction of apoptosis [UNKNOWN]
    negative regulation of apoptosis [IMP]
    apoptosis [UNKNOWN]
    mRNA transport [IEA]
    positive regulation of muscle cell differentiation [IMP]
    Molecular Function: U6 snRNA binding [UNKNOWN]
    RNA binding [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    translation elongation factor activity [IEA]
    ribosome binding [IEA]
    protein N-terminus binding [UNKNOWN]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG  60
   61 IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG 120
  121 KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] PSI-BLAST 38.0 Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • U6 snRNA binding
    		•  7.69488393698619 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  6.60650180781768 bayes_pls_golite062009
  • structural molecule activity
    		•  6.0174879876147 bayes_pls_golite062009
  • translation initiation factor activity
    		•  5.09596850944863 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.89165617439497 bayes_pls_golite062009
  • translation elongation factor activity
    		•  3.58178742491041 bayes_pls_golite062009
  • DNA binding
    		•  3.38561002225202 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • RNA binding
    		•  1.76502371106766 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.74890841494748 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.69669059514663 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.54386990150255 bayes_pls_golite062009
  • translation regulator activity
    		•  1.46320772716954 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.40718318783582 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.38349489974693 bayes_pls_golite062009
  • protein binding
    		•  1.20309946451799 bayes_pls_golite062009
  • transcription activator activity
    		•  0.990244702925461 bayes_pls_golite062009
  • mRNA binding
    		•  0.883475899526061 bayes_pls_golite062009
  • transcription factor activity
    		•  0.859071050218437 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.594907498313479 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.474251377131502 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.47336621289748 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.47336621289748 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.35186207828037 bayes_pls_golite062009
  • nuclease activity
    		•  0.26446253803519 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle