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Protein Overview: C83A1_ARATH

General Information:
Name(s) found: C83A1_ARATH [Swiss-Prot]
Description(s) found:
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  • pir||T05246 cytochrome P450 monooxygenase [imported] - Arabidopsis thaliana [NCBI NR]
  • gi|7268081|emb|CAB78419.1| cytochrome P450 monooxygenase (CYP83A1) [Arabidopsis thaliana] [NCBI NR]
  • gi|6166038|sp|P48421.2|C83A1_ARATH RecName: Full=Cytochrome P450 83A1; AltName: Full=CYPLXXXIII [NCBI NR]
  • gi|4455306|emb|CAB36841.1| cytochrome P450 monooxygenase (CYP83A1) [Arabidopsis thaliana] [NCBI NR]
  • gi|3164128|dbj|BAA28532.1| cytochrome P450 monooxygenase [Arabidopsis thaliana] [NCBI NR]
  • gi|2454176|gb|AAB71623.1| cytochrome P450 monooxygenase [Arabidopsis thaliana] [NCBI NR]
  • gi|20857340|gb|AAM26713.1| AT4g13770/F18A5_160 [Arabidopsis thaliana] [NCBI NR]
  • gi|18700184|gb|AAL77703.1| AT4g13770/F18A5_160 [Arabidopsis thaliana] [NCBI NR]
  • gi|16226709|gb|AAL16238.1|AF428469_1 AT4g13770/F18A5_160 [Arabidopsis thaliana] [NCBI NR]
  • gi|15236349|ref|NP_193113.1| CYP83A1 (CYTOCHROME P450 83A1); oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen / oxygen binding [Arabidopsis th [NCBI NR]
  • (P48421) Cytochrome P450 83A1 (EC 1.14.-.-) (CYPLXXXIII) [Swiss-Prot]
  • Cytochrome P450 83A1 OS=Arabidopsis thaliana GN=CYP83A1 PE=1 SV=2 [Swiss-Prot]
  • cytochrome P450 monooxygenase [Arabidopsis thaliana]gi|20857340|gb|AAM26713.1| AT4g13770/F18A5_160 [Arabidopsis thaliana]gi|7268081|emb|CAB78419.1| cytochrome P450 monooxygenase (CYP83A1) [Arabidopsis thaliana]gi|4455306|emb|CAB36841.1| cytochrome P450 [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Cytochrome P450 83A1 [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: REF2, CYP83A1 | CYP83A1 (CYTOCHROME P450 83A1); oxygen binding | chr4:7990678-7992278 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • cytochrome P450 monooxygenase (CYP83A1) [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • cytochrome P450 monooxygenase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • AT4g13770/F18A5_160 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Cytochrome P450 83A1 (CYPLXXXIII) [nr-271106-contam.fasta]
  • CYP83A1 (CYTOCHROME P450 83A1); oxygen binding [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: CYP83A1, REF2 | cytochrome P450, family 83, subfamily A, polypeptide 1 | chr4:7990682-7992282 REVERSE LENGTH=502 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 502 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: glucosinolate biosynthetic process [IDA]
    response to UV [NAS]
    Molecular Function: oxygen binding [ISS]
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDIIIGVVA LAAVLLFFLY QKPKTKRYKL PPGPSPLPVI GNLLQLQKLN PQRFFAGWAK  60
   61 KYGPILSYRI GSRTMVVISS AELAKELLKT QDVNFADRPP HRGHEFISYG RRDMALNHYT 120
  121 PYYREIRKMG MNHLFSPTRV ATFKHVREEE ARRMMDKINK AADKSEVVDI SELMLTFTNS 180
  181 VVCRQAFGKK YNEDGEEMKR FIKILYGTQS VLGKIFFSDF FPYCGFLDDL SGLTAYMKEC 240
  241 FERQDTYIQE VVNETLDPKR VKPETESMID LLMGIYKEQP FASEFTVDNV KAVILDIVVA 300
  301 GTDTAAAAVV WGMTYLMKYP QVLKKAQAEV REYMKEKGST FVTEDDVKNL PYFRALVKET 360
  361 LRIEPVIPLL IPRACIQDTK IAGYDIPAGT TVNVNAWAVS RDEKEWGPNP DEFRPERFLE 420
  421 KEVDFKGTDY EFIPFGSGRR MCPGMRLGAA MLEVPYANLL LSFNFKLPNG MKPDDINMDV 480
  481 MTGLAMHKSQ HLKLVPEKVN KY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..502] PSI-BLAST 113.0 Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  5.03099580095037 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • electron carrier activity
    		•  4.64931978461551 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  4.64322346579269 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxygen binding
    		•  3.7203678182299 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • fluorene oxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • retinoic acid binding
    		•  2.70323898361882 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  2.30416050662077 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.29989218606587 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  2.13777393591805 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  2.13777393591805 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • ecdysteroid 22-hydroxylase activity
    		•  1.58167166311061 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  1.48500938886158 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.880940639082655 bayes_pls_golite062009
  • protein binding
    		•  0.836411857417911 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.614118857213859 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • iron ion binding
    		•  0.529598228513719 bayes_pls_golite062009
  • cation binding
    		•  0.510556740388808 bayes_pls_golite062009
  • metal ion binding
    		•  0.510556740388808 bayes_pls_golite062009
  • ion binding
    		•  0.503326724714616 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  0.377799149936808 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.41

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle