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Protein Overview: kin-18

General Information:
Name(s) found: kin-18 / CE32936 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00002201 locus:kin-18 Serine\/threonine-protein kinase SULU status:Confirmed UniProt:P46549 protein_id:CCD63181.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 353 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of pharyngeal pumping [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    feeding behavior [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPAVLQKPG VIKDPSIAAL FSNKDPEQRY QDLREIGHGS FGAVYFAYDK KNEQTVAIKK  60
   61 MNFSGKQAVE KWNDILKEVS FLNTVVHPHI VDYKACFLKD TTCWLVMEYC IGSAADIVDV 120
  121 LRKGMREVEI AAICSQTLDA LRYLHSLKRI HRDIKAGNIL LSDHAIVKLA DFGSASLVDP 180
  181 AQTFIGTPFF MAPEVILAMD EGHYTDRADI WSLGITCIEL AERRPPLFSM NAMSALYHIA 240
  241 QNDPPTLSPI DTSEQPEWSL EFVQFIDKCL RKPAEERMSA EECFRHPFIQ RSRPSDTIQE 300
  301 LIQRTKNMVL ELDNFQYKKM RKLMYLDETE GKEGSEGNGA SDDLDFHGNE NHG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..353] PSI-BLAST 67.69897 Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • MAP kinase 2 activity
    		•  3.27009208121248 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.93176092222748 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.90354666768303 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • signal transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.71452519680794 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • telethonin binding
    		•  1.59285057739948 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.27184436658773 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.23667636311593 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.19908793854422 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • structural molecule activity
    		•  1.10436308210353 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  1.03605423743048 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.913893847407112 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.821371946077904 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • receptor activity
    		•  0.775180603313375 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.713064190387634 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.461392047923247 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • potassium channel regulator activity
    		•  0.359831178301818 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.328289063778519 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.267404531445803 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • histone kinase activity (H3-S10 specific)
    		•  0.25011115126171 bayes_pls_golite062009
  • cation channel activity
    		•  0.245400615103891 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle