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Protein Overview: nep-2

General Information:
Name(s) found: nep-2 / CE30162 [WormBase]
Description(s) found:
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  • WBGene00020230 locus:nep-2 status:Partially_confirmed UniProt:O44857 protein_id:CCD73586.1 [WormBase]
  • gi|25148650|ref|NP_494343.2| NEPrilysin metallopeptidase family member (nep-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|18030163|gb|AAB95021.2| Hypothetical protein T05A8.4 [Caenorhabditis elegans] [NCBI NR]
  • Neprilysin-2 OS=Caenorhabditis elegans GN=nep-2 PE=1 SV=2 [Swiss-Prot]
  • [wormpep79.fasta]
  • CE30162 WBGene00020230 protease status:Partially_confirmed TR:O44857 protein_id:AAB95021.2 [wormpep150.fasta]
  • 30162 WBGene00020230 protease status:Partially_confirmed TR:O44857 protein_id:AAB95021.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • neprilysin-like zinc metallo-peptidase (2D10) [Caenorhabditis elegans]gi|18030163|gb|AAB95021.2| Hypothetical protein T05A8.4 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • protease status:Partially_confirmed TR:O44857 protein_id:AAB95021.2 [wormpep115.fasta.reversed]
  • CE30162 protease status:Partially_confirmed TR:O44857 protein_id:AAB95021.2 [wormpep80.hongbin]
  • CE30162 WBGene00020230 locus:nep-2 protease status:Partially_confirmed UniProt:O44857_CAEEL protein_id:AAB95021.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE30162 WBGene00020230 locus:nep-2 protease status:Partially_confirmed UniProt:O44857_CAEEL protein_id:AAB95021.2| [wormORF-contam.fasta]
  • Hypothetical protein T05A8.4 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • T05A8.4 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE30162 WBGene00020230 locus:nep-2 protease status:Partially_confirmed TR:O44857 protein_id:AAB95021.2 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE30162 WBGene00020230 locus:nep-2 protease status:Partially_confirmed UniProt:O44857 protein_id:AAB95021.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE30162 WBGene00020230 locus:nep-2 protease status:Partially_confirmed UniProt:O44857 protein_id:CCD73586.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE30162 WBGene00020230 locus:nep-2 status:Partially_confirmed UniProt:O44857 protein_id:CCD73586.1 [wormpep246-ecoli-contam.fasta]
  • CE30162 WBGene00020230 locus:nep-2 status:Partially_confirmed UniProt:O44857 protein_id:CCD73586.1 Neprilysin-2 [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 736 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: zinc ion binding [IEALink to PubMed article]
    neprilysin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPDEEDGTT KSPGSRWTRI WAIIALILLI LFLLVLGAAI YFYINYKDSS DVCLSPGCIK  60
   61 TASVILSSMN SSVDPCDDFY EFACGQWIKG HPIPDDAPSV SNFENLGQDL EFALKELLDE 120
  121 NDEPYDYETS AVGKAKYFYN LCLNESEILD NWRTTFDEVV KSFGGWPSLG HQMKPDASIE 180
  181 MLYADMVAKF KADSLFKATV QPDDKNSQRH VLLIDQPQLN LFARDFYVAA ENEERMAYLQ 240
  241 LIRDVLILLD ADRTRATLDA KEIIDFETAL ANITMADEHR HDIAELYTKI TLGEMRRSLP 300
  301 HFNWPLFFNR MFKDLHEKNG KRITFDDNTE VVVYGYEFLR RLDVLIPQYD NRLIVNYLEW 360
  361 CWFFKTMLRD LPDPFALTIF KFYKTLNIMN VQKVRWHGCV TRINSLMPMA TSAIYVKNHF 420
  421 DHEAKQQVEE MISLIMESFV DLLLSEDWLT KETKQTAKQK VNEMKRKIGY PDYLNDPAAV 480
  481 NNEYKTFKVY PGHYYQTKFS FYEQYQRDVL ERITEAVDRE RWVAGAALVN AFYSPNTNEI 540
  541 IFPAGILQPV FYSKDFPSSM NFGGIGVVIG HEITHGFDDR GRLYDNLGNI RQWWDNATIS 600
  601 KFEHKAQCIE KQYSSYVLDQ INMQINGKST KGENIADNGG LKQAYRAYKK YEKRHSRPPR 660
  661 LPGVNLTHDQ LFFLNYAQIW CGTMNDKEAI RKLRTSEHSP GPIRVKGPLS NSYDFAKAYN 720
  721 CEPGSQMNPR EKCRVW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..736] PSI-BLAST 1000.0 Neutral endopeptidase (neprilysin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.33358263548929 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.99457783001146 bayes_pls_golite062009
  • bradykinin receptor binding
    		•  4.68498310889748 bayes_pls_golite062009
  • endopeptidase activity
    		•  4.16532996235931 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.94798058866011 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  3.43236442601127 bayes_pls_golite062009
  • peptidyl-dipeptidase activity
    		•  3.15882456934259 bayes_pls_golite062009
  • hydrolase activity
    		•  2.61181165622708 bayes_pls_golite062009
  • angiotensin receptor activity
    		•  2.47329778652768 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  2.40931483220122 bayes_pls_golite062009
  • exopeptidase activity
    		•  2.07461908743946 bayes_pls_golite062009
  • receptor binding
    		•  2.07222569254168 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.71636138555452 bayes_pls_golite062009
  • receptor activity
    		•  1.71573921458029 bayes_pls_golite062009
  • peptide binding
    		•  1.58227634414618 bayes_pls_golite062009
  • protein binding
    		•  1.58118182554863 bayes_pls_golite062009
  • binding
    		•  1.55761777216628 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42071856700201 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42071856700201 bayes_pls_golite062009
  • viral receptor activity
    		•  1.39617252453036 bayes_pls_golite062009
  • epoxide hydrolase activity
    		•  1.37998417474643 bayes_pls_golite062009
  • ether hydrolase activity
    		•  1.18753073809881 bayes_pls_golite062009
  • protein complex binding
    		•  1.16270782056592 bayes_pls_golite062009
  • integrin binding
    		•  0.93449223670512 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  0.711782218042781 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.61233964043845 bayes_pls_golite062009
  • peptide receptor activity, G-protein coupled
    		•  0.597899738932066 bayes_pls_golite062009
  • peptide receptor activity
    		•  0.574641388356132 bayes_pls_golite062009
  • zinc ion binding
    		•  0.49304764842799 bayes_pls_golite062009
  • hydrolase activity, acting on ether bonds
    		•  0.457157426475929 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.393080846858665 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.374597710524442 bayes_pls_golite062009
  • growth factor activity
    		•  0.259654587796416 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.252655558968584 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.21808506596674 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.21514043665594 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle