| Protein: | nep-2 |
| Organism: | Caenorhabditis elegans |
| Length: | 736 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nep-2.
| Description | E-value | Query Range |
Subject Range |
|
|
813.0 | [0..5] | [736..34] |
|
Region A: Residues: [1-736] |
1 11 21 31 41 51
| | | | | |
1 MRPDEEDGTT KSPGSRWTRI WAIIALILLI LFLLVLGAAI YFYINYKDSS DVCLSPGCIK 60
61 TASVILSSMN SSVDPCDDFY EFACGQWIKG HPIPDDAPSV SNFENLGQDL EFALKELLDE 120
121 NDEPYDYETS AVGKAKYFYN LCLNESEILD NWRTTFDEVV KSFGGWPSLG HQMKPDASIE 180
181 MLYADMVAKF KADSLFKATV QPDDKNSQRH VLLIDQPQLN LFARDFYVAA ENEERMAYLQ 240
241 LIRDVLILLD ADRTRATLDA KEIIDFETAL ANITMADEHR HDIAELYTKI TLGEMRRSLP 300
301 HFNWPLFFNR MFKDLHEKNG KRITFDDNTE VVVYGYEFLR RLDVLIPQYD NRLIVNYLEW 360
361 CWFFKTMLRD LPDPFALTIF KFYKTLNIMN VQKVRWHGCV TRINSLMPMA TSAIYVKNHF 420
421 DHEAKQQVEE MISLIMESFV DLLLSEDWLT KETKQTAKQK VNEMKRKIGY PDYLNDPAAV 480
481 NNEYKTFKVY PGHYYQTKFS FYEQYQRDVL ERITEAVDRE RWVAGAALVN AFYSPNTNEI 540
541 IFPAGILQPV FYSKDFPSSM NFGGIGVVIG HEITHGFDDR GRLYDNLGNI RQWWDNATIS 600
601 KFEHKAQCIE KQYSSYVLDQ INMQINGKST KGENIADNGG LKQAYRAYKK YEKRHSRPPR 660
661 LPGVNLTHDQ LFFLNYAQIW CGTMNDKEAI RKLRTSEHSP GPIRVKGPLS NSYDFAKAYN 720
721 CEPGSQMNPR EKCRVW
|
| Detection Method: |  |
| Confidence: | 1000.0 |
| Match: | 1dmtA |
| Description: | Neutral endopeptidase (neprilysin) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| peptidase activity | 5.33358263548929 | bayes_pls_golite062009 |
| peptidase activity, acting on L-amino acid peptides | 4.99457783001146 | bayes_pls_golite062009 |
| bradykinin receptor binding | 4.68498310889748 | bayes_pls_golite062009 |
| endopeptidase activity | 4.16532996235931 | bayes_pls_golite062009 |
| metallopeptidase activity | 3.94798058866011 | bayes_pls_golite062009 |
| metalloendopeptidase activity | 3.43236442601127 | bayes_pls_golite062009 |
| peptidyl-dipeptidase activity | 3.15882456934259 | bayes_pls_golite062009 |
| hydrolase activity | 2.61181165622708 | bayes_pls_golite062009 |
| angiotensin receptor activity | 2.47329778652768 | bayes_pls_golite062009 |
| G-protein coupled receptor activity | 2.40931483220122 | bayes_pls_golite062009 |
| exopeptidase activity | 2.07461908743946 | bayes_pls_golite062009 |
| receptor binding | 2.07222569254168 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.71636138555452 | bayes_pls_golite062009 |
| receptor activity | 1.71573921458029 | bayes_pls_golite062009 |
| peptide binding | 1.58227634414618 | bayes_pls_golite062009 |
| protein binding | 1.58118182554863 | bayes_pls_golite062009 |
| binding | 1.55761777216628 | bayes_pls_golite062009 |
| molecular transducer activity | 1.42071856700201 | bayes_pls_golite062009 |
| signal transducer activity | 1.42071856700201 | bayes_pls_golite062009 |
| viral receptor activity | 1.39617252453036 | bayes_pls_golite062009 |
| epoxide hydrolase activity | 1.37998417474643 | bayes_pls_golite062009 |
| ether hydrolase activity | 1.18753073809881 | bayes_pls_golite062009 |
| protein complex binding | 1.16270782056592 | bayes_pls_golite062009 |
| integrin binding | 0.93449223670512 | bayes_pls_golite062009 |
| catalytic activity | 0.891187593353827 | bayes_pls_golite062009 |
| interleukin-6 receptor binding | 0.711782218042781 | bayes_pls_golite062009 |
| cytokine receptor binding | 0.61233964043845 | bayes_pls_golite062009 |
| peptide receptor activity, G-protein coupled | 0.597899738932066 | bayes_pls_golite062009 |
| peptide receptor activity | 0.574641388356132 | bayes_pls_golite062009 |
| zinc ion binding | 0.49304764842799 | bayes_pls_golite062009 |
| hydrolase activity, acting on ether bonds | 0.457157426475929 | bayes_pls_golite062009 |
| serine hydrolase activity | 0.393080846858665 | bayes_pls_golite062009 |
| serine-type peptidase activity | 0.374597710524442 | bayes_pls_golite062009 |
| growth factor activity | 0.259654587796416 | bayes_pls_golite062009 |
| serine-type endopeptidase activity | 0.252655558968584 | bayes_pls_golite062009 |
| aminopeptidase activity | 0.21808506596674 | bayes_pls_golite062009 |
| transition metal ion binding | 0.21514043665594 | bayes_pls_golite062009 |
