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Protein Overview: eat-16

General Information:
Name(s) found: eat-16 / CE17404 [WormBase]
Description(s) found:
Found 18 descriptions.
SHOW ALL
  • WBGene00001145 locus:eat-16 status:Confirmed UniProt:O17589 protein_id:CAB02742.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 473 amino acids

    Gene Ontology:
    Cellular Component: heterotrimeric G-protein complex [IEALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    neuron projection [IDALink to PubMed article]
    Biological Process: response to food [IMPLink to PubMed article]
    negative regulation of locomotion [IMPLink to PubMed article]
    regulation of locomotion [IMPLink to PubMed article]
    G-protein coupled receptor protein signaling pathway [IEALink to PubMed article]
    dopamine receptor signaling pathway [IMPLink to PubMed article]
    regulation of G-protein coupled receptor protein signaling pathway [IDALink to PubMed article][IGILink to PubMed article]
    reproduction [IMPLink to PubMed article]
    regulation of pharyngeal pumping [IMPLink to PubMed article]
    inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway [IDALink to PubMed article]
    regulation of oviposition [IMPLink to PubMed article]
    nematode larval development [IGILink to PubMed article]
    regulation of GTPase activity [IGILink to PubMed article]
    regulation of synaptic transmission [IGILink to PubMed article]
    Molecular Function: GTPase activator activity [IGILink to PubMed article]
    regulator of G-protein signaling activity [IDALink to PubMed article][IGILink to PubMed article]
    signal transducer activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMPPLTKIEV LAKRVMEGAQ LKTHKYFRIA VPHAITGQQL IALVLERGAP DDEAEASHLA  60
   61 SLLLHHGYMF PVIEHGQPFK DDGTLYRLQR PYFWPSQAEL VPDVEYAIYL NKRLLRNEQK 120
  121 HGLEEDEVES FNRLADVLAH MWAFIVQQSE LQLKQQKEKK KVDKVVFDSE ERAFWKIRKP 180
  181 SRGGPNFLED PYMKIEKKIR RQNAQGYRCL MDRLRFAIKT KPWLKALKAS DTMVTWVDQR 240
  241 AEFDPFLHPP QPSNPWISDE ASFWNQPTDT SSAEIPTEKR VKRWGLSVQE LVKDPIGRQV 300
  301 LETFLESEFS SENIRFWIAI QDLKYAPNEQ IYQKAERIRE EFLAQGAPAQ VNVDNRTLDQ 360
  361 TLECISKAKD ASQMRFAFYH SEEHVFTLMA KDSYPRFVRS QIYKAVLTAA QQHGTKRLGW 420
  421 RNFVFNMGTT KKPATSKPAK PQDSIGTGQV LPKQLSSDSL PVRQAHGVKP DPE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..247] PSI-BLAST 24.39794 Regulatory domain of epac2, domain 2; Regulatory domain of Epac2, domains 1 and 3
    2 View Details [248..473] PSI-BLAST 36.0 RGS9, RGS domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific channel activity
    		•  3.81400803751315 bayes_pls_golite062009
  • gated channel activity
    		•  3.75615867846417 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.71111882888041 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.71111882888041 bayes_pls_golite062009
  • cation channel activity
    		•  3.61025292543387 bayes_pls_golite062009
  • ion channel activity
    		•  3.49583875363169 bayes_pls_golite062009
  • channel activity
    		•  3.47292007271524 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  3.47292007271524 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.28757379242869 bayes_pls_golite062009
  • binding
    		•  2.23085040327125 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.09857147539905 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.83682117020899 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.73592246548483 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  1.68618484766279 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  1.51216484289697 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.4788427609721 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.29733029674587 bayes_pls_golite062009
  • signal transducer activity
    		•  1.29733029674587 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  1.26984296847489 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  1.26984296847489 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.817946345456311 bayes_pls_golite062009
  • protein binding
    		•  0.81302068072988 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.788367835670939 bayes_pls_golite062009
  • transcription factor binding
    		•  0.63938506997853 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.49916895549368 bayes_pls_golite062009
  • DNA binding
    		•  0.49707830237564 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.470291687819709 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.46805096166885 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.46337812086906 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.238077419568415 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.235806909995514 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.215760255961604 bayes_pls_golite062009
  • transcription factor activity
    		•  0.192522789488363 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.18055371101756 bayes_pls_golite062009
  • receptor binding
    		•  0.0995086620605325 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.0560460005338929 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.35238988967981 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.92987277493861 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.90800479999702 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.87534424848905 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.62073651679221 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.49796137854909 bayes_pls_golite062009
  • protein binding
    		•  1.34804002381061 bayes_pls_golite062009
  • signal transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.59248827140739 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle