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Protein Overview: hsk1

General Information:
Name(s) found: hsk1 / SPBC776.12c [Sanger Pombe]
Description(s) found:
Found 24 descriptions.
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  • serine/threonine protein kinase Hsk1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 507 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Dbf4-dependent protein kinase complex [TASLink to PubMed article]
    Biological Process: DNA replication initiation [IGILink to PubMed article]
    DNA replication checkpoint [IGILink to PubMed article]
    replication fork protection [IGILink to PubMed article]
    chromosome organization [IMPLink to PubMed article]
    G1/S transition of mitotic cell cycle [IMPLink to PubMed article]
    replication fork arrest [IGILink to PubMed article]
    protein amino acid phosphorylation [IEA]
    mating type switching [IMPLink to PubMed article]
    regulation of centromeric sister chromatid cohesion [IGILink to PubMed article]
    Molecular Function: ATP binding [IDALink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein heterodimerization activity [IPILink to PubMed article]
    protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEAHITLSP KVTHEQQTDI DSECEITEVD DENVNENKSQ EMIQDIPARD REEIENITRT  60
   61 FVELQENYRL IEKIGEGTFS SVYKAEDLHY GRYINDWDIQ SEVLKESSFG KEKIPVNEDS 120
  121 RKPKYVAIKK IYATSSPARI YNELEILYLL RGSSVIAPLI TALRNEDQVL VVLPYYEHTD 180
  181 FRQYYSTFSY RDMSIYFRCL FQAMQQTQTL GIIHRDIKPS NFLFDVRTKH GVLVDFGLAE 240
  241 RYDGRQQSHS CRCTNSNAAE LAHDFSIAQE TSLGYIKNDT RPSKRANRAG TRGFRAPEVL 300
  301 FKCSSQSPKV DIWSAGVILL SFLTKRFPMF NSKDDVDALM EIACIFGKSE MRQCAALHGC 360
  361 TFETNVSTLT EKRVNFRKLI LWASCGSASI YKEKLRHKPS QEERLCLDFL EKCLELDCNK 420
  421 RISAEEALDH DFLYLDNLAY EKKDDDTAFD NSFGETSFEK DEDLTAKHLS HILDFKEQEE 480
  481 TDEPTSLSKR KRSIDEILPN DALQDGA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..507] PSI-BLAST 53.0 MAP kinase p38-gamma

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • structural molecule activity
    		•  2.32133082120229 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.68012041942855 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.47162554695064 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.4045088027491 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.4045088027491 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.2662335835562 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.99838484913572 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.913893847407112 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • receptor activity
    		•  0.775180603313375 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.666159109886349 bayes_pls_golite062009
  • activin binding
    		•  0.664317770352101 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.57617745233877 bayes_pls_golite062009
  • activin receptor activity
    		•  0.558143200755109 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • RNA binding
    		•  0.245748631571068 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • transporter activity
    		•  0.187543377461637 bayes_pls_golite062009
  • growth factor binding
    		•  0.153144089598532 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.149958560815481 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.149958560815481 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.14842991990838 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.0795689006739899 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.0413380592707298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle