Protein Overview: CalpC-PA

General Information:
Name(s) found:	CalpC-PA / FBpp0074005 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|24642465\|ref\|NP_573118.2\| calpain C [Drosophila melanogaster] [NCBI NR] gi\|229541100\|sp\|Q9VXH6.4\|CANC_DROME RecName: Full=Calpain-C; AltName: Full=Calcium-activated neutral proteinase homolog C; Short=CANP C [NCBI NR] gi\|22832353\|gb\|AAF48591.2\| calpain C [Drosophila melanogaster] [NCBI NR] Calpain-C OS=Drosophila melanogaster GN=CalpC PE=1 SV=4 [Swiss-Prot] The gene Calpain C is referred to in FlyBase by the symbol Dmel\CalpC (CG3692, FBgn0260450). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16219802..16222560. It has the cytological map location 14B13. It is reported to have molecular function</span>: calcium-dependent cysteine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG3692-PA translation from_gene[CG3692 CG3692 FBgn0030741] seq_release:3 mol_weight=77449 cds_boundaries:(X:16,056,953..16,059,069[+]) aa_length:681 transcript_info:[CG3692-RA seq_release:3] gene_info:[gene symbol:CG3692 FBgn0030741 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta] (Q9VXH6) CG3692 protein [DrosMelano7227.FASTAC.txt] CG3692-PA [Drosophila melanogaster]gi\|24642465\|ref\|NP_573118.2\| CG3692-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=X:join(16219967..16220700,16220775..16222086); ID=FBpp0074005; name=CalpC-PA; parent=FBgn0260450,FBtr0074226; dbxref=FlyBase:FBpp0074005,FlyBase_Annotation_IDs:CG3692-PA,GB_protein:AAF48591.2,REFSEQ:NP_573118,GB_protein:AAF48591; MD5=7e5 [fly-100309-contam.fasta] Calpain C CG3692-PA [Drosophila melanogaster] [nr-271106-contam.fasta] CG3692-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=X:join(16219967..16220700,16220775..16222086); ID=FBpp0074005; name=CalpC-PA; parent=FBgn0260450,FBtr0074226; dbxref=FlyBase:FBpp0074005,FlyBase_Annotation_IDs:CG3692-PA,GB_protein:AAF48591.2,REFSEQ:NP_573118,GB_protein:AAF48591; MD5=7e54306e35f3ae33516cd277eb929f49; length=681; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:join(16219967..16220700,16220775..16222086); ID=FBpp0074005; name=CalpC-PA; parent=FBgn0260450,FBtr0074226; dbxref=FlyBase:FBpp0074005,FlyBase_Annotation_IDs:CG3692-PA,GB_protein:AAF48591.2,REFSEQ:NP_573118,GB_protein:AAF48591; MD5=7e54306e35f3ae33516cd277eb929f49; length=681; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=X:join(16219967..16220700,16220775..16222086); ID=FBpp0074005; name=CalpC-PA; parent=FBgn0260450,FBtr0074226; dbxref=FlyBase:FBpp0074005,FlyBase_Annotation_IDs:CG3692-PA,GB_protein:AAF48591.2,REFSEQ:NP_573118,GB_protein:AAF48591,FlyMine:FBpp0074005,modMine:FBpp0074005; MD5=7e54306e35f3ae33516cd277eb929f49; length=681; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=X:join(16325934..16326667,16326742..16328053); ID=FBpp0074005; name=CalpC-PA; parent=FBgn0260450,FBtr0074226; dbxref=FlyBase:FBpp0074005,FlyBase_Annotation_IDs:CG3692-PA,GB_protein:AAF48591.2,REFSEQ:NP_573118,GB_protein:AAF48591,FlyMine:FBpp0074005,modMine:FBpp0074005; MD5=7e54306e35f3ae33516cd277eb929f49; length=681; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:join(16325934..16326667,16326742..16328053); ID=FBpp0074005; name=CalpC-PA; parent=FBgn0260450,FBtr0074226; dbxref=FlyBase:FBpp0074005,FlyBase_Annotation_IDs:CG3692-PA,GB_protein:AAF48591.2,REFSEQ:NP_573118,GB_protein:AAF48591,FlyMine:FBpp0074005,modMine:FBpp0074005; MD5=7e54306e35f3ae33516cd277eb929f49; length=681; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0074005 type=protein; loc=X:join(16325934..16326667,16326742..16328053); ID=FBpp0074005; name=CalpC-PA; parent=FBgn0260450,FBtr0074226; dbxref=FlyBase:FBpp0074005,FlyBase_Annotation_IDs:CG3692-PA,GB_protein:AAF48591.2,REFSEQ:NP_573118,GB_protein:AAF48591,FlyMine:FBpp0074005,modMine:FBpp0074005; MD5=7e54306e35f3ae33516cd277eb929f49; length=681; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=X:join(16325934..16326667,16326742..16328053); ID=FBpp0074005; name=CalpC-PA; parent=FBgn0260450,FBtr0074226; dbxref=FlyBase:FBpp0074005,FlyBase_Annotation_IDs:CG3692-PA,GB_protein:AAF48591.2,REFSEQ:NP_573118,GB_protein:AAF48591,UniProt/Swiss-Prot:Q9VXH6,FlyMine:FBpp0074005,modMine:FBpp0074005; MD5=7e54306e35f3ae33516cd277eb929f49; length=681; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	681 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [NAS] intracellular [IEA]
Biological Process:	proteolysis [IEA][NAS]
Molecular Function:	calcium ion binding [IEA] [NOT]calcium-dependent cysteine-type endopeptidase activity [IEA][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASKYERILS DCRSKNVLWE DPDFPAVQSS VFYYQTPPFT FQWKRIMDLA DSGSGAVAAN  60
   61 SSAAPVFLNE SAEFDVVPGK MGDRWLVSCL GLLSSLRNLF YRVVPADQTL ASAHGVFRFR 120
  121 LWWCGEWVEV LVDDRLPTIN GRLAFMQPQA SNCFWAALLE KAIAKLHGSY EALKYGTRSD 180
  181 GLTDLLGGVV RQMPILSDNI RPQTLKELLT TTCIVTCLAD KSATVAKKNL AERMPNGILV 240
  241 NVNYRLSSLD KVKTLMGDSV QLVCLKDTFS SKPFGEKTHF LGDWSPMSKT WERVSQVERA 300
  301 RLIRQLGPGE FWLSFCDFVE IFSTMEVVYL DTETSNDEEM LKSRPLHWKM KMHQGQWKRG 360
  361 VTAGGCRNHE SFHINPQLLI SVQDEQDLVI ALNQHTAVEP KVIGFTMYTW DGEYMLSECL 420
  421 QKDFFKNHVS YLNSDYGNTR HVSYHTHLEA GHYVLIPTTY EPAEEAHFTV RILGTGSFRL 480
  481 SCLETQTMIL LDPFPALKST DAERCGGPKV KSVCQYEPVY MQLADENKTI NCFELHELLE 540
  541 ACLPNDYIKG CANIDICRQV IALQDRSGSG RITFQQFKTF MVNLKSWQGV FKMYTKEKAG 600
  601 ILRAERLRDA LCDIGFQLST DIMNCLIQRY IRKDGTLRLS DFVSAVIHLT TAFNQFHLKN 660
  661 YGQVNVIEVH LHDWIKSILS C

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
structural constituent of muscle	6.34041234021534	bayes_pls_golite062009
myosin heavy chain binding	4.20811099622311	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.95815414384	bayes_pls_golite062009
peptidase activity	3.19059336788201	bayes_pls_golite062009
cysteine-type peptidase activity	3.05412701733177	bayes_pls_golite062009
endopeptidase activity	2.91734319991078	bayes_pls_golite062009
hydrolase activity	2.43328552376748	bayes_pls_golite062009
troponin T binding	2.39237700612893	bayes_pls_golite062009
myosin II heavy chain binding	2.30950552746179	bayes_pls_golite062009
ion transmembrane transporter activity	2.29802198409541	bayes_pls_golite062009
cation transmembrane transporter activity	2.28098452079347	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.16689842778043	bayes_pls_golite062009
cysteine-type endopeptidase activity	1.95802900199539	bayes_pls_golite062009
protein binding	1.92445772322782	bayes_pls_golite062009
binding	1.92046698500094	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.74951443813569	bayes_pls_golite062009
transporter activity	1.21845572420504	bayes_pls_golite062009
actin binding	1.1967948958876	bayes_pls_golite062009
cytoskeletal protein binding	1.19670958990587	bayes_pls_golite062009
signal transducer activity	1.11706264292297	bayes_pls_golite062009
molecular transducer activity	1.11706264292297	bayes_pls_golite062009
small conjugating protein-specific protease activity	1.07520173658976	bayes_pls_golite062009
catalytic activity	1.05972260874031	bayes_pls_golite062009
transmembrane transporter activity	1.00091316610003	bayes_pls_golite062009
nitric-oxide synthase binding	0.965098383344279	bayes_pls_golite062009
nucleic acid binding	0.952536088972875	bayes_pls_golite062009
cation channel activity	0.856991182112951	bayes_pls_golite062009
calcium ion binding	0.687204894708051	bayes_pls_golite062009
motor activity	0.68020805045422	bayes_pls_golite062009
transcription regulator activity	0.654911807161532	bayes_pls_golite062009
DNA binding	0.561772300480686	bayes_pls_golite062009
microfilament motor activity	0.515693296786409	bayes_pls_golite062009
ubiquitin-specific protease activity	0.495368836247989	bayes_pls_golite062009
substrate-specific transporter activity	0.484449686814032	bayes_pls_golite062009
substrate-specific channel activity	0.366129174039334	bayes_pls_golite062009
	0.34446792626966	bayes_pls_golite062009
voltage-gated cation channel activity	0.341357838238159	bayes_pls_golite062009
channel regulator activity	0.32809521759917	bayes_pls_golite062009
voltage-gated channel activity	0.308919475701377	bayes_pls_golite062009
voltage-gated ion channel activity	0.304496519713588	bayes_pls_golite062009
potassium channel activity	0.260530997378698	bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity	0.196538841514154	bayes_pls_golite062009
active transmembrane transporter activity	0.193338880082314	bayes_pls_golite062009
gated channel activity	0.175191914660841	bayes_pls_golite062009
calcium-dependent protein binding	0.170792976663713	bayes_pls_golite062009
voltage-gated potassium channel activity	0.157059988605635	bayes_pls_golite062009
tubulin binding	0.11107511867058	bayes_pls_golite062009
passive transmembrane transporter activity	0.0711800677928949	bayes_pls_golite062009
channel activity	0.0711800677928949	bayes_pls_golite062009
protein complex binding	0.0676093357928913	bayes_pls_golite062009
ion channel activity	0.0166394982861724	bayes_pls_golite062009
transcription factor activity	0.00805573746748856	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..681]	PSI-BLAST	165.0	Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)

Protein Overview: CalpC-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: