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Protein Overview: Mcm6-PA

General Information:
Name(s) found: Mcm6-PA / FBpp0070913 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Minichromosome maintenance 6 is referred to in FlyBase by the symbol Dmel\Mcm6 (CG4039, FBgn0025815). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6568422..6571205. It has the cytological map location 6C4-6C5. There is experimental evidence that it has the molecular function</span>: 3'-5' DNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: eggshell chorion gene amplification; DNA replication. 10 alleles are reported. The phenotypes of these alleles are annotated with: chorion; imaginal disc; larval brain; dorsal appendage. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 817 amino acids

    Gene Ontology:
    Cellular Component: pre-replicative complex [ISS][NAS]
    nucleus [IDA]
    Biological Process: DNA replication initiation [IEA]
    eggshell chorion gene amplification [IMP][TAS]
    oogenesis [TAS]
    DNA replication [IEA][IMP][TAS]
    pre-replicative complex assembly [ISS][NAS]
    Molecular Function: ATP binding [IEA]
    DNA binding [IEA]
    chromatin binding [ISS][NAS]
    3'-5' DNA helicase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVADAQVGQ LRVKDEVGIR AQKLFQDFLE EFKEDGEIKY TRPAASLESP DRCTLEVSFE  60
   61 DVEKYDQNLA TAIIEEYYHI YPFLCQSVSN YVKDRIGLKT QKDCYVAFTE VPTRHKVRDL 120
  121 TTSKIGTLIR ISGQVVRTHP VHPELVSGVF MCLDCQTEIR NVEQQFKFTN PTICRNPVCS 180
  181 NRKRFMLDVE KSLFLDFQKI RIQETQAELP RGCIPRAVEI ILRSELVETV QAGDRYDFTG 240
  241 TLIVVPDVSV LAGVGTRAEN SSRHKPGEGM DGVTGLKALG MRELNYRMAF LACSVQATTA 300
  301 RFGGTDLPMS EVTAEDMKKQ MTDAEWHKIY EMSKDRNLYQ NLISSLFPSI YGNDEVKRGI 360
  361 LLQQFGGVAK TTTEKTSLRG DINVCIVGDP STAKSQFLKQ VSDFSPRAIY TSGKASSAAG 420
  421 LTAAVVRDEE SFDFVIEAGA LMLADNGICC IDEFDKMDQR DQVAIHEAME QQTISIARAG 480
  481 VRATLNARTS ILAAANPING RYDRSKSLQQ NIQLSAPIMS RFDLFFILVD ECNEVVDYAI 540
  541 ARKIVDLHSN IEESVERAYT REEVLRYVTF ARQFKPVISQ EAGHMLVENY GHLRQRDTGT 600
  601 SGRSTWRITV RQLESMIRLS EAMAKLECSN RVLERHVKEA FRLLNKSIIR VEQPDIHLDD 660
  661 DEGLDMDDGI QHDIDMENNG AAANVDENNG MDTSASGAVQ KKKFTLSFED YKNLSTMLVL 720
  721 HMRAEEARCE VEGNDTGIKR SNVVTWYLEQ VADQIESEDE LISRKNLIEK LIDRLIYHDQ 780
  781 VIIPLKTSTL KPRIQVQKDF VEEDDPLLVV HPNYVVE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 37.522879 DNA replication initiator (cdc21/cdc54) N-terminal domain
    2 View Details [214..350] PSI-BLAST 52.154902 Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
    3 View Details [351..817] PSI-BLAST 14.09691 EDTA treated

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • telomeric DNA binding
    		•  4.81350293592083 bayes_pls_golite062009
  • telomerase inhibitor activity
    		•  4.48082903165152 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  4.34033743483519 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.29626483284963 bayes_pls_golite062009
  • DNA binding
    		•  3.71771169141041 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.51998515668903 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  3.48139490984491 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  3.43027351695641 bayes_pls_golite062009
  • structural molecule activity
    		•  3.29857127235306 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10110937001387 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.9581702424972 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.84819558112187 bayes_pls_golite062009
  • translation regulator activity
    		•  1.46320772716954 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.40718318783582 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.30343463892105 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • transcription activator activity
    		•  1.24141936405635 bayes_pls_golite062009
  • protein binding
    		•  1.20309946451799 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14242112812892 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.12203697857261 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.638831894247026 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.635129001787169 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.474251377131502 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.47336621289748 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.47336621289748 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.325774164899685 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.31769813397725 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.314881439089948 bayes_pls_golite062009
  • exonuclease activity
    		•  0.28313884527829 bayes_pls_golite062009
  • transferase activity
    		•  0.249054945579328 bayes_pls_golite062009
  • RNA binding
    		•  0.18502033889261 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.125256208482441 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.109774918833391 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.0954216620147701 bayes_pls_golite062009
  • DEAD/H-box RNA helicase binding
    		•  0.0627405398613412 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.0179535526984695 bayes_pls_golite062009
  • helicase activity
    		•  0.0121541775159524 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  6.79355468178926 bayes_pls_golite062009
  • DNA binding
    		•  4.415807849754 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.28683790544043 bayes_pls_golite062009
  • transcription factor activity
    		•  3.6562075225277 bayes_pls_golite062009
  • signal transducer activity
    		•  3.29384659525629 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.29384659525629 bayes_pls_golite062009
  • two-component response regulator activity
    		•  2.59441224418158 bayes_pls_golite062009
  • binding
    		•  2.56389923453102 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.99486600109539 bayes_pls_golite062009
  • protein kinase activity
    		•  1.9601175626899 bayes_pls_golite062009
  • kinase activity
    		•  1.87109561693077 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.52421871214976 bayes_pls_golite062009
  • transcription activator activity
    		•  1.21008827533914 bayes_pls_golite062009
  • protein binding
    		•  0.688721058758568 bayes_pls_golite062009
  • transferase activity
    		•  0.633276440680247 bayes_pls_golite062009
    3
    Term Confidence Notes
  • DNA clamp loader activity
    		•  4.91429252297969 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  4.80695929076807 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.66107861968804 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.0142766759353 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.62491387774159 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.53142082854758 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.52938239070386 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.52887308780164 bayes_pls_golite062009
  • nucleotide binding
    		•  1.52746968836881 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • ATP binding
    		•  1.23942044024113 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.21044170258803 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.20315703345493 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.19481945569892 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • kinase activity
    		•  1.11120928120082 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.05408274676326 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.908046791062776 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.8469248456592 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  0.700780808446722 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.421921195209539 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.406600732518248 bayes_pls_golite062009
  • protein kinase activity
    		•  0.351308564667977 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • transferase activity
    		•  0.175269600441384 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.156278588350022 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13366911641814 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.0223627159838333 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle