| Protein: | Mcm6-PA |
| Organism: | Drosophila melanogaster |
| Length: | 817 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Mcm6-PA.
| Description | E-value | Query Range |
Subject Range |
|
|
656.0 | [0..1] | [817..1] |
|
Region A: Residues: [1-213] |
1 11 21 31 41 51
| | | | | |
1 MDVADAQVGQ LRVKDEVGIR AQKLFQDFLE EFKEDGEIKY TRPAASLESP DRCTLEVSFE 60
61 DVEKYDQNLA TAIIEEYYHI YPFLCQSVSN YVKDRIGLKT QKDCYVAFTE VPTRHKVRDL 120
121 TTSKIGTLIR ISGQVVRTHP VHPELVSGVF MCLDCQTEIR NVEQQFKFTN PTICRNPVCS 180
181 NRKRFMLDVE KSLFLDFQKI RIQETQAELP RGC
|
| Detection Method: |  |
| Confidence: | 37.522879 |
| Match: | 1ltlA |
| Description: | DNA replication initiator (cdc21/cdc54) N-terminal domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| telomeric DNA binding | 4.81350293592083 | bayes_pls_golite062009 |
| telomerase inhibitor activity | 4.48082903165152 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 4.34033743483519 | bayes_pls_golite062009 |
| nucleic acid binding | 4.29626483284963 | bayes_pls_golite062009 |
| DNA binding | 3.71771169141041 | bayes_pls_golite062009 |
| structural constituent of ribosome | 3.51998515668903 | bayes_pls_golite062009 |
| structure-specific DNA binding | 3.48139490984491 | bayes_pls_golite062009 |
| single-stranded DNA binding | 3.43027351695641 | bayes_pls_golite062009 |
| structural molecule activity | 3.29857127235306 | bayes_pls_golite062009 |
| binding | 2.83465364476231 | bayes_pls_golite062009 |
| transcription regulator activity | 2.10110937001387 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.9581702424972 | bayes_pls_golite062009 |
| DNA replication origin binding | 1.84819558112187 | bayes_pls_golite062009 |
| translation regulator activity | 1.46320772716954 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 1.40718318783582 | bayes_pls_golite062009 |
| transcription repressor activity | 1.30343463892105 | bayes_pls_golite062009 |
| translation initiation factor activity | 1.27539679024898 | bayes_pls_golite062009 |
| transcription activator activity | 1.24141936405635 | bayes_pls_golite062009 |
| protein binding | 1.20309946451799 | bayes_pls_golite062009 |
| RNA polymerase activity | 1.19766815287926 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 1.19766815287926 | bayes_pls_golite062009 |
| ribonuclease activity | 1.19236946227657 | bayes_pls_golite062009 |
| transcription factor activity | 1.14242112812892 | bayes_pls_golite062009 |
| DNA helicase activity | 1.12203697857261 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.638831894247026 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.635129001787169 | bayes_pls_golite062009 |
| nuclease activity | 0.57381531077345 | bayes_pls_golite062009 |
| aminoacyl-tRNA ligase activity | 0.474251377131502 | bayes_pls_golite062009 |
| ligase activity, forming carbon-oxygen bonds | 0.47336621289748 | bayes_pls_golite062009 |
| ligase activity, forming aminoacyl-tRNA and related compounds | 0.47336621289748 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 0.325774164899685 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.31769813397725 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.314881439089948 | bayes_pls_golite062009 |
| exonuclease activity | 0.28313884527829 | bayes_pls_golite062009 |
| transferase activity | 0.249054945579328 | bayes_pls_golite062009 |
| RNA binding | 0.18502033889261 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 0.125256208482441 | bayes_pls_golite062009 |
| exoribonuclease activity | 0.109774918833391 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0954216620147701 | bayes_pls_golite062009 |
| DEAD/H-box RNA helicase binding | 0.0627405398613412 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.0179535526984695 | bayes_pls_golite062009 |
| helicase activity | 0.0121541775159524 | bayes_pls_golite062009 |
|
Region A: Residues: [214-350] |
1 11 21 31 41 51
| | | | | |
1 IPRAVEIILR SELVETVQAG DRYDFTGTLI VVPDVSVLAG VGTRAENSSR HKPGEGMDGV 60
61 TGLKALGMRE LNYRMAFLAC SVQATTARFG GTDLPMSEVT AEDMKKQMTD AEWHKIYEMS 120
121 KDRNLYQNLI SSLFPSI
|
| Detection Method: | |
| Confidence: | 52.154902 |
| Match: | 1ny5A |
| Description: | Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 6.79355468178926 | bayes_pls_golite062009 |
| DNA binding | 4.415807849754 | bayes_pls_golite062009 |
| nucleic acid binding | 4.28683790544043 | bayes_pls_golite062009 |
| transcription factor activity | 3.6562075225277 | bayes_pls_golite062009 |
| signal transducer activity | 3.29384659525629 | bayes_pls_golite062009 |
| molecular transducer activity | 3.29384659525629 | bayes_pls_golite062009 |
| two-component response regulator activity | 2.59441224418158 | bayes_pls_golite062009 |
| binding | 2.56389923453102 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.99486600109539 | bayes_pls_golite062009 |
| protein kinase activity | 1.9601175626899 | bayes_pls_golite062009 |
| kinase activity | 1.87109561693077 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.52421871214976 | bayes_pls_golite062009 |
| transcription activator activity | 1.21008827533914 | bayes_pls_golite062009 |
| protein binding | 0.688721058758568 | bayes_pls_golite062009 |
| transferase activity | 0.633276440680247 | bayes_pls_golite062009 |
|
Region A: Residues: [351-817] |
1 11 21 31 41 51
| | | | | |
1 YGNDEVKRGI LLQQFGGVAK TTTEKTSLRG DINVCIVGDP STAKSQFLKQ VSDFSPRAIY 60
61 TSGKASSAAG LTAAVVRDEE SFDFVIEAGA LMLADNGICC IDEFDKMDQR DQVAIHEAME 120
121 QQTISIARAG VRATLNARTS ILAAANPING RYDRSKSLQQ NIQLSAPIMS RFDLFFILVD 180
181 ECNEVVDYAI ARKIVDLHSN IEESVERAYT REEVLRYVTF ARQFKPVISQ EAGHMLVENY 240
241 GHLRQRDTGT SGRSTWRITV RQLESMIRLS EAMAKLECSN RVLERHVKEA FRLLNKSIIR 300
301 VEQPDIHLDD DEGLDMDDGI QHDIDMENNG AAANVDENNG MDTSASGAVQ KKKFTLSFED 360
361 YKNLSTMLVL HMRAEEARCE VEGNDTGIKR SNVVTWYLEQ VADQIESEDE LISRKNLIEK 420
421 LIDRLIYHDQ VIIPLKTSTL KPRIQVQKDF VEEDDPLLVV HPNYVVE
|
| Detection Method: | |
| Confidence: | 14.09691 |
| Match: | 2ce7A |
| Description: | EDTA treated |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| DNA clamp loader activity | 4.91429252297969 | bayes_pls_golite062009 |
| protein-DNA loading ATPase activity | 4.80695929076807 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 2.72462789867829 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 2.66107861968804 | bayes_pls_golite062009 |
| binding | 2.64537357529343 | bayes_pls_golite062009 |
| nucleic acid binding | 2.51683451033161 | bayes_pls_golite062009 |
| DNA helicase activity | 2.2817164193758 | bayes_pls_golite062009 |
| pyrophosphatase activity | 2.13284212711072 | bayes_pls_golite062009 |
| DNA binding | 2.12258000781149 | bayes_pls_golite062009 |
| transcription regulator activity | 2.09345198747025 | bayes_pls_golite062009 |
| telomeric DNA binding | 2.0142766759353 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 1.88455339138556 | bayes_pls_golite062009 |
| helicase activity | 1.70242731830224 | bayes_pls_golite062009 |
| microtubule motor activity | 1.6537049553461 | bayes_pls_golite062009 |
| DNA replication origin binding | 1.62491387774159 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.53142082854758 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.52938239070386 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.52887308780164 | bayes_pls_golite062009 |
| nucleotide binding | 1.52746968836881 | bayes_pls_golite062009 |
| structural constituent of ribosome | 1.47858140861683 | bayes_pls_golite062009 |
| ATP binding | 1.23942044024113 | bayes_pls_golite062009 |
| protein binding | 1.22129154759482 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.21044170258803 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.20315703345493 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.19481945569892 | bayes_pls_golite062009 |
| purine NTP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| ATP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| motor activity | 1.14667913749579 | bayes_pls_golite062009 |
| kinase activity | 1.11120928120082 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| double-stranded DNA binding | 1.05408274676326 | bayes_pls_golite062009 |
| catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
| DNA-directed DNA polymerase activity | 0.971476020912368 | bayes_pls_golite062009 |
| DNA polymerase activity | 0.928091843881235 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.908046791062776 | bayes_pls_golite062009 |
| transcription activator activity | 0.889929694023098 | bayes_pls_golite062009 |
| transcription factor activity | 0.887108427603557 | bayes_pls_golite062009 |
| structural molecule activity | 0.86514677273731 | bayes_pls_golite062009 |
| transcription repressor activity | 0.862685397469217 | bayes_pls_golite062009 |
| hydrogen ion transporting ATP synthase activity, rotational mechanism | 0.8469248456592 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 0.700780808446722 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.543891899378373 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.500462538667228 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.421921195209539 | bayes_pls_golite062009 |
| single-stranded DNA binding | 0.406600732518248 | bayes_pls_golite062009 |
| protein kinase activity | 0.351308564667977 | bayes_pls_golite062009 |
| translation regulator activity | 0.29096092258568 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 0.274994961137851 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.26252931460003 | bayes_pls_golite062009 |
| exodeoxyribonuclease V activity | 0.185603938981231 | bayes_pls_golite062009 |
| RNA helicase activity | 0.18426050934025 | bayes_pls_golite062009 |
| transferase activity | 0.175269600441384 | bayes_pls_golite062009 |
| hydrogen ion transmembrane transporter activity | 0.156278588350022 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.147579541298736 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 0.14606996093053 | bayes_pls_golite062009 |
| mismatched DNA binding | 0.13366911641814 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 0.13050483816765 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.113504049290503 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.111293884322157 | bayes_pls_golite062009 |
| 3'-5' DNA helicase activity | 0.0769112340058804 | bayes_pls_golite062009 |
| monovalent inorganic cation transmembrane transporter activity | 0.0223627159838333 | bayes_pls_golite062009 |
| actin binding | 0.00482938540552702 | bayes_pls_golite062009 |
