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Protein Overview: Klp3A-PA, FBpp03...

General Information:
Name(s) found: FBpp0309092 [FlyBase]
Klp3A-PA / FBpp0070432 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=X:complement(2493706..2493751,2493812..2494308,2494392..2496655,2496727..2496878,2496952..2497631); ID=FBpp0309092; name=Klp3A-PB; parent=FBgn0011606,FBtr0340093; dbxref=FlyBase:FBpp0309092,FlyBase_Annotation_IDs:CG8590-PB; MD5=a17ca4a1a34a34631c8da4e11c553361; length=1212; release=r5.56; species=Dmel; [FlyBase]
  • The gene Kinesin-like protein at 3A is referred to in FlyBase by the symbol Dmel\Klp3A (CG8590, FBgn0011606). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2493190..2498085. It has the cytological map location 3A6. There is experimental evidence that it has the molecular function</span>: microtubule binding. There is experimental evidence that it is involved in the biological process</span>: female meiosis chromosome segregation; reciprocal meiotic recombination; spindle pole body separation; chromosome segregation; regulation of mitosis; mitotic spindle organization; cytokinesis; spindle elongation; male meiosis; single fertilization. 15 alleles are reported. The phenotypes of these alleles are annotated with: spindle microtubule; Nebenkern; spindle pole; spermatid; spermatocyte ring canal; astral microtubule; meiotic cell cycle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1212 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    intermediate layer of spindle pole body [IDA]
    central plaque of spindle pole body [IDA]
    cytoplasm [IDA]
    spindle [IDA]
    aster [IDA]
    kinesin complex [ISS][NAS]
    midbody [IDA]
    microtubule associated complex [IDA]
    Biological Process: reciprocal meiotic recombination [IMP]
    spindle elongation [IMP]
    regulation of mitosis [IMP]
    spindle pole body separation [IMP]
    male meiosis [IMP][TAS]
    mitotic spindle organization [IMP]
    pronuclear fusion [TAS]
    cytokinesis [IMP][TAS]
    chromosome segregation [IMP]
    female meiosis chromosome segregation [IMP]
    microtubule-based movement [ISS]
    single fertilization [IMP]
    Molecular Function: ATP binding [IEA]
    microtubule motor activity [ISS]
    plus-end-directed microtubule motor activity [NAS]
    microtubule binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEDPSCVA VALRVRPLVQ SELDRGCRIA VERSADGAPQ VTVNRNESYT YNYVFDIDDS  60
   61 QKDLFETCVQ AKVKKLLNGY NVTILAYGQT GSGKTYTMGT AFNGVLDDHV GVIPRAVHDI 120
  121 FTAIAEMQSE FRFAVTCSFV ELYQEQFYDL FSSKTRDKAT VDIREVKNRI IMPGLTELVV 180
  181 TSAQQVTDHL IRGSAGRAVA ATAMNETSSR SHAIFTLTLV ATKLDGKQSV TTSRFNLVDL 240
  241 AGSERCSKTL ASGDRFKEGV NINKGLLALG NVINALGSGQ AAGYIPYRQS KLTRLLQDSL 300
  301 GGNSITLMIA CVSPADYNVA ETLSTLRYAD RALQIKNKPV VNLDPHAAEV NMLKDVIQKL 360
  361 RVELLSGGKM SSSLISAVGA AGLGAIPCEE SLAGSMANAA EIQRLKEQVR TLQDRNRKLQ 420
  421 QELHQSLLDL TEKEMRAHIA EQAHDKLRSH VSELKNKLDQ REQAQFGNEN TNGDNEMRDF 480
  481 SLLVNRVHVE LQRTQEELES QGHESRQRLS SRSHTEGGES GGDEVHEMLH SHSEEYTNKQ 540
  541 MNFAGELRNI NRQLDLKQEL HERIMRNFSR LDSDDEDVKL RLCNQKIDDL EAERRDLMDQ 600
  601 LRNIKSKDIS AKLAEERRKR LQLLEQEISD LRRKLITQAN LLKIRDKERE KIQNLSTEIR 660
  661 TMKESKVKLI RAMRGESEKF RQWKMVREKE LTQLKSKDRK MQSEIVRQQT LHSKQRQVLK 720
  721 RKCEEALAAN KRLKDALERQ ASAQAQRHKY KDNGGSAAGS SNANAKTDSW VDRELEIILS 780
  781 LIDAEHSLEQ LMEDRAVINN HYHLLQQEKT SDPAEAAEQA RILASLEEEL EMRNAQISDL 840
  841 QQKVCPTDLD SRIRSLAEGV QSLGESRTVS KQLLKTLVQQ RRLQASSLNE QRTTLDELRA 900
  901 QLLDAQQQED AASKRLRLLQ SQHEEQMLAQ QRAYEEKVSV LIRTANQRWA EARSPAEDQQ 960
  961 RNQILEELLS SREALQQELD KLRAKNKSKS KAVKSEPQDL DDSFQIVDGN ETVVLSDVSD1020
 1021 DPDWVPSTSK SKRIQSDSRN VISPPEKQDA NVTSLGNSSI QSLNSTSATE DGKRCKGCKC1080
 1081 RTKCTTKRCG CLSGNNACSE TCVCKSNCRN PLNLKDHASQ CGDGDGQKDE TEDADKSDDD1140
 1141 GDDEPQTSKE NAVKFVTPEA PGKVVASPKQ TLQEPKAAAT PLMNSNVVED INGPKLAKMS1200
 1201 GLAFDTPKRK FF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..354] PSI-BLAST 100.0 Kinesin
    2 View Details [355..524] FFAS03 1.59 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    3 View Details [525..1212] PSI-BLAST 5.39794 No description for 2dfsA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.4348680404207 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.08697924060619 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • DNA binding
    		•  0.702147676354075 bayes_pls_golite062009
  • beta-tubulin binding
    		•  0.654735466720932 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • microtubule-severing ATPase activity
    		•  0.491769258942331 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • alpha-tubulin binding
    		•  0.100557713995661 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle