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View Structure Prediction Details

Protein: Klp3A-PA, FBpp03...
Organism: Drosophila melanogaster
Length: 1212 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Klp3A-PA, FBpp03....

Description E-value Query
Range
Subject
Range
gi|29421214 - gi|29421214|dbj|BAA31614.3| KIAA0639 protein [Homo sapiens]
382.0 [0..6] [1102..12]

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Predicted Domain #1
Region A:
Residues: [1-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEDPSCVA VALRVRPLVQ SELDRGCRIA VERSADGAPQ VTVNRNESYT YNYVFDIDDS  60
   61 QKDLFETCVQ AKVKKLLNGY NVTILAYGQT GSGKTYTMGT AFNGVLDDHV GVIPRAVHDI 120
  121 FTAIAEMQSE FRFAVTCSFV ELYQEQFYDL FSSKTRDKAT VDIREVKNRI IMPGLTELVV 180
  181 TSAQQVTDHL IRGSAGRAVA ATAMNETSSR SHAIFTLTLV ATKLDGKQSV TTSRFNLVDL 240
  241 AGSERCSKTL ASGDRFKEGV NINKGLLALG NVINALGSGQ AAGYIPYRQS KLTRLLQDSL 300
  301 GGNSITLMIA CVSPADYNVA ETLSTLRYAD RALQIKNKPV VNLDPHAAEV NMLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 100.0
Match: 1gojA
Description: Kinesin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 7.68336791348661 bayes_pls_golite062009
plus-end-directed microtubule motor activity 4.97507344344589 bayes_pls_golite062009
microfilament motor activity 4.176620576177 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
actin-dependent ATPase activity 2.77140616759165 bayes_pls_golite062009
microtubule plus-end binding 2.71138928021716 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
transporter activity 2.58140740499725 bayes_pls_golite062009
ATP-dependent DNA helicase activity 2.4348680404207 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
transmembrane transporter activity 2.39695871109024 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
ATPase activity, coupled 2.18396165590908 bayes_pls_golite062009
actin binding 1.75397031486306 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.40384549325664 bayes_pls_golite062009
substrate-specific transporter activity 1.29730375126024 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
nucleic acid binding 1.08697924060619 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.906554174337376 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
actin filament binding 0.728264616959762 bayes_pls_golite062009
DNA binding 0.702147676354075 bayes_pls_golite062009
beta-tubulin binding 0.654735466720932 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
kinetochore binding 0.505370954958131 bayes_pls_golite062009
microtubule-severing ATPase activity 0.491769258942331 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
guanyl nucleotide binding 0.399434758448606 bayes_pls_golite062009
GTP binding 0.398333597279278 bayes_pls_golite062009
guanyl ribonucleotide binding 0.39332178627529 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
ion transmembrane transporter activity 0.355466224802969 bayes_pls_golite062009
RNA helicase activity 0.34746349346164 bayes_pls_golite062009
histone acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.30832907234141 bayes_pls_golite062009
RNA-dependent ATPase activity 0.29532978396745 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
protein transporter activity 0.178442534411253 bayes_pls_golite062009
alpha-tubulin binding 0.100557713995661 bayes_pls_golite062009
minus-end-directed microtubule motor activity 0.068779631341469 bayes_pls_golite062009
cation transmembrane transporter activity 0.0254369227200564 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [355-524]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVIQKLRVEL LSGGKMSSSL ISAVGAAGLG AIPCEESLAG SMANAAEIQR LKEQVRTLQD  60
   61 RNRKLQQELH QSLLDLTEKE MRAHIAEQAH DKLRSHVSEL KNKLDQREQA QFGNENTNGD 120
  121 NEMRDFSLLV NRVHVELQRT QEELESQGHE SRQRLSSRSH TEGGESGGDE 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.59
Match: 1jchA
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [525-1212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHEMLHSHSE EYTNKQMNFA GELRNINRQL DLKQELHERI MRNFSRLDSD DEDVKLRLCN  60
   61 QKIDDLEAER RDLMDQLRNI KSKDISAKLA EERRKRLQLL EQEISDLRRK LITQANLLKI 120
  121 RDKEREKIQN LSTEIRTMKE SKVKLIRAMR GESEKFRQWK MVREKELTQL KSKDRKMQSE 180
  181 IVRQQTLHSK QRQVLKRKCE EALAANKRLK DALERQASAQ AQRHKYKDNG GSAAGSSNAN 240
  241 AKTDSWVDRE LEIILSLIDA EHSLEQLMED RAVINNHYHL LQQEKTSDPA EAAEQARILA 300
  301 SLEEELEMRN AQISDLQQKV CPTDLDSRIR SLAEGVQSLG ESRTVSKQLL KTLVQQRRLQ 360
  361 ASSLNEQRTT LDELRAQLLD AQQQEDAASK RLRLLQSQHE EQMLAQQRAY EEKVSVLIRT 420
  421 ANQRWAEARS PAEDQQRNQI LEELLSSREA LQQELDKLRA KNKSKSKAVK SEPQDLDDSF 480
  481 QIVDGNETVV LSDVSDDPDW VPSTSKSKRI QSDSRNVISP PEKQDANVTS LGNSSIQSLN 540
  541 STSATEDGKR CKGCKCRTKC TTKRCGCLSG NNACSETCVC KSNCRNPLNL KDHASQCGDG 600
  601 DGQKDETEDA DKSDDDGDDE PQTSKENAVK FVTPEAPGKV VASPKQTLQE PKAAATPLMN 660
  661 SNVVEDINGP KLAKMSGLAF DTPKRKFF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.39794
Match: 2dfsA
Description: No description for 2dfsA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle