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Protein Overview: Caki-PB

General Information:
Name(s) found: Caki-PB / FBpp0083559 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Calcium/calmodulin-dependent protein kinase is referred to in FlyBase by the symbol Dmel\Caki (CG6703, FBgn0013759). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17611484..17648364. It has the cytological map location 93F10-93F12. There is experimental evidence that it has the molecular function</span>: calmodulin-dependent protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; adult walking behavior; cell adhesion. 12 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 898 amino acids

    Gene Ontology:
    Cellular Component: calcium- and calmodulin-dependent protein kinase complex [ISS]
    membrane [NAS]
    Biological Process: regulation of cell shape [IMP]
    adult walking behavior [IMP]
    synaptic vesicle targeting [NAS]
    synaptic vesicle docking during exocytosis [NAS]
    establishment or maintenance of cell polarity [NAS]
    cell adhesion [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    neurotransmitter secretion [NAS]
    Molecular Function: ATP binding [IEA]
    protein binding [IEA]
    calmodulin-dependent protein kinase activity [IDA][ISS][NAS]
    guanylate kinase activity [NAS]
    protein serine/threonine kinase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEDEILFDD VYELCEVIGK GPFSIVRRCI HRESNQQFAV KIVDVAKFTA SPGLSTADLK  60
   61 REATICHMLK HPHIVELLET YSSEGMLYMV FEFMEGSDLC FEVVRRAVAG FVYSEAVACH 120
  121 YMRQILEALR YCHENDILHR DVRPACALLA TVDNSAPVKL GGFGSAIQLP GTRETIETHG 180
  181 RVGCPHYMAP EVVTRRLYGK GCDVWGAGVM LHVLLSGRLP FLGSGVRLQQ SVARGRLSFE 240
  241 APEWKSISAN AKDLVMKMLA ANPHHRLSIT EVLDHPWIRD RDKLQRTHLA DTVEELKRYN 300
  301 ARRKLKGAVQ AIAGGTNMDP LYATDADMPI TGATDEWADE EAGIEAVQRI LDCLDDIYSL 360
  361 QDAHVDADVL RDMLRDNRLH QFLQLFDRIA ATVVTSNGRA PAAEAVGRCR DVLEQLSSTS 420
  421 GGNSLGGKYA KEELMRLLAA PHMQALLHSH DVVARDVYGE EALRVTPPPM VPYLNGDELD 480
  481 NVEGGELQHV TRVRLVQFQK NTDEPMGITL KMTEDGRCIV ARIMHGGMIH RQATLHVGDE 540
  541 IREINGQPVQ HQSVGQLQRM LREARGSVTF KIVPSYRSAP PPCEIFVRAQ FDYNPLDDEL 600
  601 IPCAQAGISF QVGDILQIIS KDDHHWWQAR LDTVGGSAGL IPSPELQEWR IACQTVDKTK 660
  661 QEQVNCSIFG RKKKQCRDKY LAKHNAIFDT LDVVTYEEVV KVPVGDPNFQ RKTLVLLGAH 720
  721 GVGRRHIKNT LISKYPDKYA YPIPHTTRPA KPEEENGRSY YFVSHDEMMA DIGANEYLEY 780
  781 GTHEDAMYGT KLDTIRRIHT EGKMAILDVE PQALKILRTA EFTPYVVFIA APSLQNIADY 840
  841 DGSLERLAKE SEMLRQLYGH FFDLTIVNND ISETIATLET AIDRVHTTPQ WVPVSWLY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..346] PSI-BLAST 75.09691 Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II
    2 View Details [347..391] Pfam 14.075721 No description for PF02828.7 was found. No confident structure predictions are available.
    3 View Details [392..488] FFAS03 2.52 NMR structure of L27 heterodimer from C. elegans Lin-7 and H. sapiens Lin-2 scaffold proteins
    4 View Details [489..591] PSI-BLAST 10.30103 Cask/Lin-2
    5 View Details [592..703] PSI-BLAST 12.522879 Crystal structure of the Rattus norvegicus voltage gated calcium channel beta subunit isoform 2a
    6 View Details [704..898] PSI-BLAST 59.0 Guanylate kinase-like domain of Cask

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.60106431937699 bayes_pls_golite062009
  • protein binding
    		•  3.40921081688513 bayes_pls_golite062009
  • binding
    		•  3.2595117613307 bayes_pls_golite062009
  • actin binding
    		•  3.17546881601441 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16834620509051 bayes_pls_golite062009
  • kinase activity
    		•  1.60310055540266 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.55801612135974 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.51162321843898 bayes_pls_golite062009
  • signal transducer activity
    		•  1.51162321843898 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.42576125485675 bayes_pls_golite062009
  • PDZ domain binding
    		•  1.4161955255054 bayes_pls_golite062009
  • transcription activator activity
    		•  1.37255187012662 bayes_pls_golite062009
  • actin filament binding
    		•  1.36043531087419 bayes_pls_golite062009
  • cyclase inhibitor activity
    		•  1.19377184850067 bayes_pls_golite062009
  • guanylate cyclase inhibitor activity
    		•  1.19377184850067 bayes_pls_golite062009
  • transporter activity
    		•  1.18978519116375 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07211582292329 bayes_pls_golite062009
  • transferase activity
    		•  1.02891276124789 bayes_pls_golite062009
  • structural molecule activity
    		•  0.906026957959903 bayes_pls_golite062009
  • receptor binding
    		•  0.867295068429704 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.755223974149211 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.665461219385567 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.64214865642772 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.549085929250683 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.449763185979101 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252733105474942 bayes_pls_golite062009
  • myosin binding
    		•  0.24204561023371 bayes_pls_golite062009
  • cytokine activity
    		•  0.200378971638035 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.182094987832726 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.0801784133682708 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0283953080227368 bayes_pls_golite062009
    5
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  4.41722924924158 bayes_pls_golite062009
  • actin binding
    		•  4.40611495471342 bayes_pls_golite062009
  • actin filament binding
    		•  3.14048820255876 bayes_pls_golite062009
  • protein binding
    		•  3.13677730481089 bayes_pls_golite062009
  • binding
    		•  3.06905798270146 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.80011194349017 bayes_pls_golite062009
  • signal transducer activity
    		•  1.80011194349017 bayes_pls_golite062009
  • transporter activity
    		•  1.30447542854757 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08558010881058 bayes_pls_golite062009
  • vinculin binding
    		•  1.06590166080776 bayes_pls_golite062009
  • structural molecule activity
    		•  0.989403012920596 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.91790790672461 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.820987609295422 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.570864043201529 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.371928447183203 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.277388904131159 bayes_pls_golite062009
  • receptor binding
    		•  0.0742205785215131 bayes_pls_golite062009
    6
    Term Confidence Notes
  • motor activity
    		•  3.73454248797903 bayes_pls_golite062009
  • microtubule motor activity
    		•  3.635272252933 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin binding
    		•  2.7930150868804 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.94043121469819 bayes_pls_golite062009
  • tubulin binding
    		•  1.92557767696163 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.85943679361938 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.85937484083653 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.8521191028835 bayes_pls_golite062009
  • nucleotide binding
    		•  1.84603132945448 bayes_pls_golite062009
  • microtubule binding
    		•  1.84561785126784 bayes_pls_golite062009
  • kinase activity
    		•  1.80889641165674 bayes_pls_golite062009
  • actin filament binding
    		•  1.69345106007864 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.60386625568858 bayes_pls_golite062009
  • ATP binding
    		•  1.5859264197035 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  1.56774112771668 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.55520429131224 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.53158018507951 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  1.46040955642981 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.23094623498843 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.14475274823167 bayes_pls_golite062009
  • signal transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • protein kinase activity
    		•  1.12864835254143 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.02902153401888 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.977589506905452 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • transferase activity
    		•  0.871779313294914 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.864424650691313 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.75415390146713 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.656009904481476 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.64416740142962 bayes_pls_golite062009
  • GTP binding
    		•  0.643084645864898 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.567883621045161 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • protein transporter activity
    		•  0.498432226280822 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.41398614759796 bayes_pls_golite062009
  • receptor activity
    		•  0.381142123108547 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.355770151889237 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.345873656782869 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.208665086324262 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.120185906020979 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle