Protein Overview: FBpp0306705, Pi3...

General Information:
Name(s) found:	FBpp0306705 [FlyBase] Pi3K92E-PB / FBpp0083349 [FlyBase] Pi3K92E-PA / FBpp0083348 [FlyBase]
Description(s) found: Found 49 descriptions. SHOW ALL	type=protein; loc=3R:complement(16455469..16455597,16455661..16455780,16455849..16456019,16456079..16456385,16456442..16457029,16457231..16457437,16457500..16459244); ID=FBpp0306705; name=Pi3K92E-PC; parent=FBgn0015279,FBtr0334643; dbxref=FlyBase:FBpp0306705,FlyBase_Annotation_IDs:CG4141-PC,REFSEQ:NP_001262770,GB_protein:AGB96150; MD5=3af9bc06a7c1bc81aaa07d01cd7141db; length=1088; release=r5.56; species=Dmel; [FlyBase] The gene Pi3K92E is referred to in FlyBase by the symbol Dmel\Pi3K92E (CG4141, FBgn0015279). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16454694..16460430. It has the cytological map location 92F3. There is experimental evidence that it has the molecular function</span>: phosphatidylinositol-4-phosphate 3-kinase activity; lipid kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity. There is experimental evidence for 17 unique biological process</span> terms, many of which group under: regulation of biological process; anatomical structure development; instar larval development; larval development; diapause; phospholipid metabolic process; larval feeding behavior; positive regulation of cellular biosynthetic process; regulation of developmental process; regulation of anatomical structure size; gland morphogenesis; reproductive process in a multicellular organism; catabolic process; response to chemical stimulus. 27 alleles are reported. The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system; peripheral nervous system; external compound sense organ; adult segment; nervous system; adult mesothoracic segment; cytoplasmic part; thoracic segment; vacuole; imaginal precursor. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene Pi3K92E is referred to in FlyBase by the symbol Dmel\Pi3K92E (CG4141, FBgn0015279). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16454694..16460430. It has the cytological map location 92F3. There is experimental evidence that it has the molecular function</span>: phosphatidylinositol-4-phosphate 3-kinase activity; lipid kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity. There is experimental evidence for 17 unique biological process</span> terms, many of which group under: regulation of biological process; anatomical structure development; instar larval development; larval development; diapause; phospholipid metabolic process; larval feeding behavior; positive regulation of cellular biosynthetic process; regulation of developmental process; regulation of anatomical structure size; gland morphogenesis; reproductive process in a multicellular organism; catabolic process; response to chemical stimulus. 27 alleles are reported. The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system; peripheral nervous system; external compound sense organ; adult segment; nervous system; adult mesothoracic segment; cytoplasmic part; thoracic segment; vacuole; imaginal precursor. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1088 amino acids
Gene Ontology:
Cellular Component:	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [IPI][NAS]
Biological Process:	positive regulation of growth [TAS] regulation of multicellular organism growth [IMP][NAS] germ-band shortening [IMP] positive regulation of translation [IMP] insulin receptor signaling pathway [NAS][TAS] regulation of cell size [IMP][NAS] phosphoinositide phosphorylation [IDA][ISS][TAS] metamorphosis [IMP] larval development [IMP] larval salivary gland morphogenesis [IMP] instar larval development [IMP] regulation of dendrite development [IMP] response to oxidative stress [IMP] positive regulation of cell growth [NAS][TAS] positive regulation of cell size [TAS] autophagy [IMP] positive regulation of imaginal disc growth [IMP] phosphorylation [NAS] positive regulation of organ growth [IMP][NAS] regulation of organ growth [NAS] regulation of cell proliferation [IMP] larval feeding behavior [IMP] phosphoinositide-mediated signaling [IEA] oogenesis [IMP] diapause [IMP] cell growth [TAS]
Molecular Function:	lipid kinase activity [IDA] phosphatidylinositol-4,5-bisphosphate 3-kinase activity [IDA][ISS] phosphoinositide 3-kinase activity [ISS] binding [IEA] phosphatidylinositol-4-phosphate 3-kinase activity [IDA][ISS] 1-phosphatidylinositol-3-kinase activity [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMMDNRALA YVAHQPKYET PPEEAEPPCM RFSVNLWKNE MLNWVDLICL LPNGFLLELR  60
   61 VNPANTIQVI KVEMVNQAKQ MPLGYVIKEA CEYQVYGIST FNIEPYTDET KRLSEVQPYF 120
  121 GILSLGERTD TTSFSSDYEL TKMVNGMIGT TFDHNRTHGS PEIDDFRLYM TQTCDNIELE 180
  181 RSAYTWQQRL LYEHPLRLAN STKMPELIRE RHPTRTFLIV VKNENDQSTF TLSVNEQDTP 240
  241 FSLTESTLQK MNRSQMKMND RTSDYILKVS GRDEYLLGDY PLIQFLYIQE MLSDSAVPNV 300
  301 VLQSVYRLES YINHHNEQAM VTKRPLPKKR TVHLHKSISS LWDMGNYFQL TLHSISNVNF 360
  361 DKTRALKVGV HVCLYHGDKK LCAQRSTDSP NGNFDTFLFN DLVMDFDIQM RNLPRMTRLC 420
  421 IVIFEVTKMS RSKKSSNNKD IALKDVPYNK NPLAWVNTTI FDHKDILRTG RHTLYTWTYA 480
  481 DDIQSVEVFH PLGTIEPNPR KEECALVDLT FLSSGTGTVR YPSEEVVLQY AADREQVNRL 540
  541 QRQLAGPEKP IKELKELMAN YTGLDKIYEM VDQDRNAIWE RRNDILRELP EELSILLHCV 600
  601 YWKERDDVAD MWYLLKQWPL ISIERSLELL DYAYPDPAVR RFAIRCLHFL KDEDLLLYLL 660
  661 QLVQAIKHES YLESDLVVFL LERALRNQRI GHYFFWHLRS EMQTPSMQTR FGLLLEVYLK 720
  721 GCKHHVAPLR KQLHVLEKLK QGSLIAKKGS KEKVKTMLQD FLRDQRNSAV FQNIQNPLNP 780
  781 SFRCSGVTPD RCKVMDSKMR PLWVVFENAD VNASDVHIIF KNGDDLRQDM LTLQMLRVMD 840
  841 QLWKRDGMDF RMNIYNCISM EKSLGMIEVV RHAETIANIQ KEKGMFSATS PFKKGSLLSW 900
  901 LKEHNKPADK LNKAINEFTL SCAGYCVATY VLGVADRHSD NIMVKRNGQL FHIDFGHILG 960
  961 HFKEKLGVRR ERVPFVLTHD FVYVINKGFN DRESKEFCHF QELCERAFLV LRKHGCLILS1020
 1021 LFSMMISTGL PELSSEKDLD YLRETLVLDY TEEKAREHFR AKFSEALANS WKTSLNWASH1080
 1081 NFSKNNKQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
1-phosphatidylinositol-3-kinase activity	8.12544462052019	bayes_pls_golite062009
phosphoinositide 3-kinase activity	8.10715314025226	bayes_pls_golite062009
lipid kinase activity	5.98454599133418	bayes_pls_golite062009
protein kinase activity	5.63683237027974	bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity	5.59422890717019	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	4.51744163880238	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
phosphatidylinositol-4-phosphate 3-kinase activity	4.06630000313653	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	3.41480681854114	bayes_pls_golite062009
transmembrane receptor protein kinase activity	3.40140621607334	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
binding	2.31930216202447	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
structural constituent of ribosome	1.97522797979421	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
growth factor binding	1.53863828216563	bayes_pls_golite062009
MAP kinase kinase activity	1.42275431028856	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
calcium-dependent phospholipid binding	1.16085055664961	bayes_pls_golite062009
transforming growth factor beta receptor activity	1.10045286406485	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	1.10045286406485	bayes_pls_golite062009
profilin binding	1.08496596907016	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.75189004129952	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.58590430118616	bayes_pls_golite062009
insulin receptor activity	0.585036697436369	bayes_pls_golite062009
activin binding	0.510364757301021	bayes_pls_golite062009
MAP kinase activity	0.5066845540941	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
ion transmembrane transporter activity	0.388422171413648	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
phosphoinositide 3-kinase binding	0.33808087202461	bayes_pls_golite062009
cation transmembrane transporter activity	0.307012041236766	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
cell adhesion molecule binding	0.150740450460731	bayes_pls_golite062009
insulin binding	0.147382876071569	bayes_pls_golite062009
peptide binding	0.118578378753757	bayes_pls_golite062009
cation channel activity	0.0880130476088317	bayes_pls_golite062009
nucleic acid binding	0.0723883138085393	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
cation binding	0.046173055856133	bayes_pls_golite062009
metal ion binding	0.046173055856133	bayes_pls_golite062009
ion binding	0.0389662058697694	bayes_pls_golite062009
transcription regulator activity	0.0336051357091371	bayes_pls_golite062009
PTB domain binding	0.0116623342611808	bayes_pls_golite062009
DNA binding	0.0091533228439924	bayes_pls_golite062009
protein tag	0.00311613478935058	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..134]	PSI-BLAST	31.0	No description for 2v1yA was found.
2	View Details	[135..1088]	PSI-BLAST	1000.0	Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

Protein Overview: FBpp0306705, Pi3...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: