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Protein Overview: FK506-bp1-PA

General Information:
Name(s) found: FK506-bp1-PA / FBpp0082574 [FlyBase]
Description(s) found:
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  • gi|24647110|ref|NP_524364.2| FK506-binding protein 1 [Drosophila melanogaster] [NCBI NR]
  • gi|23171353|gb|AAF55171.2| FK506-binding protein 1 [Drosophila melanogaster] [NCBI NR]
  • gi|20151615|gb|AAM11167.1| LD30817p [Drosophila melanogaster] [NCBI NR]
  • gi|19860779|sp|P54397.2|FKB39_DROME RecName: Full=39 kDa FK506-binding nuclear protein; AltName: Full=Peptidyl-prolyl cis-trans isomerase; Short=PPIase; Short=Rotamase [NCBI NR]
  • (P54397) 39 kDa FK506-binding nuclear protein (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) [Swiss-Prot]
  • 39 kDa FK506-binding nuclear protein OS=Drosophila melanogaster GN=FK506-bp1 PE=1 SV=2 [Swiss-Prot]
  • The gene FK506-binding protein 1 is referred to in FlyBase by the symbol Dmel\FK506-bp1 (CG6226, FBgn0013269). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11157306..11158864. It has the cytological map location 88F1. There is experimental evidence that it has the molecular function</span>: FK506 binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of macroautophagy; negative regulation of autophagy. 7 alleles are reported. The phenotype of these alleles is annotated with: larval fat body. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG6226-PA translation from_gene[CG6226 FK506-bp1 FBgn0013269] seq_release:3 mol_weight=39344 cds_boundaries:(3R:11,157,447..11,158,768[-]) aa_length:357 transcript_info:[CG6226-RA seq_release:3] gene_info:[gene symbol:FK506-bp1 FBgn0013269 gene_bounda [hmr_yeast5_DM3-1_pombe.fasta]
  • CG6226-PA [Drosophila melanogaster]gi|20151615|gb|AAM11167.1| LD30817p [Drosophila melanogaster]gi|24647110|ref|NP_524364.2| CG6226-PA [Drosophila melanogaster]gi|19860779|sp|P54397|FKB4_DROME 39 kDa FK506-binding nuclear protein (Peptidyl-prolyl cis-t [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(11157426..11158270,11158338..11158550,11158735..11158750); ID=FBpp0082574; name=FK506-bp1-PA; parent=FBgn0013269,FBtr0083120; dbxref=FlyBase:FBpp0082574,FlyBase_Annotation_IDs:CG6226-PA,GB_protein:AAF55171.2,REFSEQ:NP_52436 [fly-100309-contam.fasta]
  • CG6226-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD30817p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • 39 kDa FK506-binding nuclear protein (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) [nr-271106-contam.fasta]
  • FK506-binding protein 1 CG6226-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(11157426..11158270,11158338..11158550,11158735..11158750); ID=FBpp0082574; name=FK506-bp1-PA; parent=FBgn0013269,FBtr0083120; dbxref=FlyBase:FBpp0082574,FlyBase_Annotation_IDs:CG6226-PA,GB_protein:AAF55171.2,REFSEQ:NP_524364,GB_protein:AAF55171; MD5=81da0d3b2da34b54d358bde310718f1a; length=357; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(11157426..11158270,11158338..11158550,11158735..11158750); ID=FBpp0082574; name=FK506-bp1-PA; parent=FBgn0013269,FBtr0083120; dbxref=FlyBase:FBpp0082574,FlyBase_Annotation_IDs:CG6226-PA,GB_protein:AAF55171.2,REFSEQ:NP_524364,GB_protein:AAF55171; MD5=81da0d3b2da34b54d358bde310718f1a; length=357; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:complement(11157426..11158270,11158338..11158550,11158735..11158750); ID=FBpp0082574; name=FK506-bp1-PA; parent=FBgn0013269,FBtr0083120; dbxref=FlyBase:FBpp0082574,FlyBase_Annotation_IDs:CG6226-PA,GB_protein:AAF55171.2,REFSEQ:NP_524364,GB_protein:AAF55171,FlyMine:FBpp0082574,modMine:FBpp0082574; MD5=81da0d3b2da34b54d358bde310718f1a; length=357; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(15333013..15333028,15332616..15332828,15331704..15332548)); ID=FBpp0082574; name=FK506-bp1-PA; parent=FBgn0013269,FBtr0083120; dbxref=FlyBase:FBpp0082574,FlyBase_Annotation_IDs:CG6226-PA,GB_protein:AAF55171.2,REFSEQ:NP_524364,GB_protein:AAF55171,FlyMine:FBpp0082574,modMine:FBpp0082574; MD5=81da0d3b2da34b54d358bde310718f1a; length=357; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(15333013..15333028,15332616..15332828,15331704..15332548)); ID=FBpp0082574; name=FK506-bp1-PA; parent=FBgn0013269,FBtr0083120; dbxref=FlyBase:FBpp0082574,FlyBase_Annotation_IDs:CG6226-PA,GB_protein:AAF55171.2,REFSEQ:NP_524364,GB_protein:AAF55171,FlyMine:FBpp0082574,modMine:FBpp0082574; MD5=81da0d3b2da34b54d358bde310718f1a; length=357; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0082574 type=protein; loc=3R:complement(join(15333013..15333028,15332616..15332828,15331704..15332548)); ID=FBpp0082574; name=FK506-bp1-PA; parent=FBgn0013269,FBtr0083120; dbxref=FlyBase:FBpp0082574,FlyBase_Annotation_IDs:CG6226-PA,GB_protein:AAF55171.2,REFSEQ:NP_524364,GB_protein:AAF55171,FlyMine:FBpp0082574,modMine:FBpp0082574; MD5=81da0d3b2da34b54d358bde310718f1a; length=357; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(15333013..15333028,15332616..15332828,15331704..15332548)); ID=FBpp0082574; name=FK506-bp1-PA; parent=FBgn0013269,FBtr0083120; dbxref=FlyBase:FBpp0082574,FlyBase_Annotation_IDs:CG6226-PA,GB_protein:AAF55171.2,REFSEQ:NP_524364,GB_protein:AAF55171,UniProt/Swiss-Prot:P54397,FlyMine:FBpp0082574,modMine:FBpp0082574; MD5=81da0d3b2da34b54d358bde310718f1a; length=357; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 357 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: negative regulation of autophagy [IMP]
    negative regulation of macroautophagy [IMP]
    protein folding [ISS][NAS]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [ISS][NAS]
    FK506 binding [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMFWGLNMK PERKYSQTII KSFHISGVAL DKGQEAKLYL AAEKQEYIVA TVTKAIPQVA  60
   61 LDLNFSKGDR IMFYTAGDAS VSLLGYLHDI DSEDDEDDDQ MTIENLLNSK AIKNSKKSED 120
  121 DEDENESGEE DEEDTDDDSQ IIEEYESFLE NGEEEDDDDV DEDNEESGEE DEQDSDDSEA 180
  181 EEEQPKAKVA KLSPGASAKK SGKEQNGVAK KEEAKQQQKK KEKPEAKKEQ PKAKEPAKQQ 240
  241 PASKDPRTIT GGVKIVDQVV GKGEEAKQGK RVSVYYIGRL QSNNKTFDSL LKGKPFKFAL 300
  301 GGGEVIKGWD VGVAGMKVGG KRVITCPPHM AYGARGAPPK IGPNSTLVFE VELKAVH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] FFAS03 1.58 Chromatin decondensation protein 1 (Crp1, Nlp)
    2 View Details [93..357] PSI-BLAST 50.221849 Macrophage infectivity potentiator protein (MIP)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone binding
    		•  3.35045437512493 bayes_pls_golite062009
  • binding
    		•  2.31105760892804 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.82337497151874 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.50414652342961 bayes_pls_golite062009
  • DNA binding
    		•  1.3333188254253 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.22112424514163 bayes_pls_golite062009
  • protein binding
    		•  1.071077076756 bayes_pls_golite062009
  • transcription factor binding
    		•  0.663916219022994 bayes_pls_golite062009
  • enzyme binding
    		•  0.420979974123408 bayes_pls_golite062009
  • catalytic activity
    		•  0.290929394811364 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  0.290017406252516 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.237741029116502 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.196866743343878 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.186970052809736 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.1843930975799 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.0973531211151839 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0172981287467382 bayes_pls_golite062009
  • NF-kappaB binding
    		•  0.00132024988427304 bayes_pls_golite062009
    2
    Term Confidence Notes
  • intracellular ligand-gated calcium channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • ryanodine-sensitive calcium-release channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • macrolide binding
    		•  7.31599503004442 bayes_pls_golite062009
  • FK506 binding
    		•  7.22442625476031 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
    		•  6.4374377859142 bayes_pls_golite062009
  • cation channel activity
    		•  6.06732269872248 bayes_pls_golite062009
  • ion channel activity
    		•  5.45007096522107 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.32426176964634 bayes_pls_golite062009
  • channel activity
    		•  5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.28960420749143 bayes_pls_golite062009
  • gated channel activity
    		•  5.28074654906904 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
    		•  2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.712368250919 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.35482339720806 bayes_pls_golite062009
  • signal transducer activity
    		•  1.35482339720806 bayes_pls_golite062009
  • drug binding
    		•  1.28204013795445 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • receptor activity
    		•  0.857814413677739 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  0.727019445105701 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.725838740508674 bayes_pls_golite062009
  • kinase activity
    		•  0.672317708125682 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.655205651562943 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.575514956833065 bayes_pls_golite062009
  • protein kinase activity
    		•  0.377540111031875 bayes_pls_golite062009
  • transferase activity
    		•  0.33716295972018 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • histone binding
    		•  0.221748741603068 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.21145105012677 bayes_pls_golite062009
  • protein binding
    		•  0.0371998661994551 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle